Issue 46, 2024

Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus

Abstract

A cationic aggregation-induced emission photosensitizer (AIE-PS) MNNPyBB has been reported to have antibacterial effects against both Gram-positive and Gram-negative bacteria. The bacterial kill mechanism has been investigated and elucidated. In a methicillin-resistant Staphylococcus aureus subcutaneous infection model, wound closure has been achieved with normal re-epithelialization and preserved skin morphology.

Graphical abstract: Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus

Supplementary files

Article information

Article type
Communication
Submitted
03 mars 2024
Accepted
07 mai 2024
First published
07 mai 2024

Chem. Commun., 2024,60, 5960-5963

Aggregation-induced emission photosensitizer for antibacterial therapy of methicillin-resistant Staphylococcus aureus

L. Kong, R. Zhang, J. Gong, H. Wang, L. Zhai, D. Dang, Q. Liu, Z. Zhao and B. Z. Tang, Chem. Commun., 2024, 60, 5960 DOI: 10.1039/D4CC01022A

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