Issue 95, 2023
From the journal:

Chemical Communications

Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window†

Ying Du,‡a   Guangyu Chu,‡b   Rui Yu,c   Rui Cui,a   Yuling Wang,a   Yiyong Mai, ORCID logo a   Ming Guan,*b   Fugui Xu*a  and  Yongfeng Zhou ORCID logo *a  

* Corresponding authors

a School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China
E-mail: yfzhou@sjtu.edu.cn, xufg1227@sjtu.edu.cn

b Department of Orthopedic Surgery, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
E-mail: guanm@zju.edu.cn

c Department of Human Biology, University of Toronto Scarborough Campus Toronto, Ontario, Canada

Abstract

A Zinc phthalocyanine-based (ZnPc–PA) polymeric micelle around 70 nm and with dual-modal PTT/PDT functions for non-antibiotic bacteria eradication was developed. It showed an excellent bacterial killing efficiency of 95.2% and 96.7% in vitro against Methicillin-resistant Staphylococcus aureus (MRSA) and its biofilm, respectively. Furthermore, the in vivo experiments proved its great potential for implant-associated infection (IAI).

Graphical abstract: Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D3CC04082H
Article type
Communication
Submitted
23 août 2023
Accepted
30 oct. 2023
First published
01 nov. 2023

Chem. Commun., 2023,59, 14169-14172

Permissions

Request permissions

Hyperbranched polyphthalocyanine micelles with dual PTT/PDT functions for bacteria eradication under an NIR window

Y. Du, G. Chu, R. Yu, R. Cui, Y. Wang, Y. Mai, M. Guan, F. Xu and Y. Zhou, Chem. Commun., 2023, 59, 14169 DOI: 10.1039/D3CC04082H

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements