Issue 32, 2022

Towards depeptidized aminoboronic acid derivatives through the use of borylated iminium ions

Abstract

Herein, we use α-boryl iminium intermediates to access progressively depeptidized branched β-aminoboronic acids that are functionalized with biologically relevant heterocycles. We investigate the interaction of these novel compounds with carbohydrates under physiological conditions and demonstrate their potential as synthetic building blocks.

Graphical abstract: Towards depeptidized aminoboronic acid derivatives through the use of borylated iminium ions

Supplementary files

Article information

Article type
Communication
Submitted
01 févr. 2022
Accepted
24 mars 2022
First published
24 mars 2022

Chem. Commun., 2022,58, 5033-5036

Towards depeptidized aminoboronic acid derivatives through the use of borylated iminium ions

V. Trudel, C. Brien, J. Tan and A. K. Yudin, Chem. Commun., 2022, 58, 5033 DOI: 10.1039/D2CC00659F

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