Targeted delivery of maytansine to liver cancer cells via galactose-modified supramolecular two-dimensional glycomaterial

Abstract

A two-dimensional (2D) glycomaterial for targeted delivery of maytansine to liver cancer cells was developed. Host–guest interaction between a galactosyl dye and human serum albumin (HSA) produces supramolecular galactoside–HSA conjugates, which are then used to coat 2D MoS₂. The 2D glycomaterial was shown to be capable of the targeted delivery of maytansine to a liver cancer cell line that highly expresses a galactose receptor, resulting in greater cytotoxicity than maytansine alone.