Issue 15, 2022

Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials

Abstract

We report the difunctional modification of an anionic cobalta bis(dicarbollide)(1) cluster with a B(8,8′)-oxygen bridging unit that provides structural rigidity and an organic alkylazide substituent(s) on the carbon atoms of the metallacarborane cage. These ions present a good binding motif for incorporation into organic molecules using Huisgen-Sharpless (2+3) cycloaddition reactions. In addition, the compounds are chiral, as verified by separation of enantiomers using HPLC on chiral stationary phases (CSPs) and provide a high electrochemical peak in the window located outside of typical signals of biomolecules.

Graphical abstract: Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials

Supplementary files

Article information

Article type
Communication
Submitted
10 déc. 2021
Accepted
18 janv. 2022
First published
18 janv. 2022

Chem. Commun., 2022,58, 2572-2575

Structurally rigidified cobalt bis(dicarbollide) derivatives, a chiral platform for labelling of biomolecules and new materials

S. El Anwar, L. Pazderová, D. Bavol, M. Bakardjiev, Z. Růžičková, O. Horáček, L. Fojt, R. Kučera and B. Grűner, Chem. Commun., 2022, 58, 2572 DOI: 10.1039/D1CC06979A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements