Issue 15, 2022
From the journal:

Chemical Communications

Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model†

Rohmad Yudi Utomo,a   Atsushi Sugie,*b   Satoshi Okada, ORCID logo acd   Kazuki Miura ORCID logo ac  and  Hiroyuki Nakamura ORCID logo *ac  

* Corresponding authors

a School of Life Science and Technology, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan
E-mail: hiro@res.titech.ac.jp

b Brain Research Institute, Niigata University, 757, Ichiban-cho, Asahimachidori, Chuo-ku, Niigata 951-8585, Japan
E-mail: atsushi.sugie@bri.niigata-u.ac.jp

c Laboratory for Chemistry and Life Science, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan

d JST, PRESTO, 4259 Nagatsuta, Midori, Yokohama, Kanagawa 226-8503, Japan

Abstract

Curcumin derivatives B and N were developed as disaggregation agents of amyloid β (Aβ) fibrils. The detoxification provided by each compound at a concentration of 1 μM was observed in neuroblastoma cells. Furthermore, both compounds significantly rescued locomotion dysfunction in an Aβ-expressing Drosophila model of Alzheimer's disease.

Graphical abstract: Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model

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Article information

DOI
https://doi.org/10.1039/D1CC07000B
Article type
Communication
Submitted
13 Dec 2021
Accepted
19 Jan 2022
First published
20 Jan 2022

Chem. Commun., 2022,58, 2576-2579

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Detoxification of amyloid β fibrils by curcumin derivatives and their verification in a Drosophila Alzheimer's model

R. Y. Utomo, A. Sugie, S. Okada, K. Miura and H. Nakamura, Chem. Commun., 2022, 58, 2576 DOI: 10.1039/D1CC07000B

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