Issue 10, 2019

Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

Abstract

The marilones and marilines are a new family of polyketide metabolites recently isolated from the marine-derived fungus Stachylidium sp. 293K04. They are characterized by a phthalide and phthalimidine skeleton, respectively. From a series of feeding experiments using 13C-labeled precursors we could outline the biogenetic origin of the basic carbon skeleton of marilone A and mariline B. Results established the tetraketide nature of the phthalide/phthalimidine nucleus including the involvement of a methylated acetate starter unit in polyketide biosynthesis, which is unique amongst fungal metabolites.

Graphical abstract: Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

Supplementary files

Article information

Article type
Paper
Submitted
25 janv. 2019
Accepted
14 févr. 2019
First published
14 févr. 2019

Org. Biomol. Chem., 2019,17, 2747-2752

Biosynthetic studies of novel polyketides from the marine sponge-derived fungus Stachylidium sp. 293K04

F. El Maddah, E. Eguereva, S. Kehraus and G. M. König, Org. Biomol. Chem., 2019, 17, 2747 DOI: 10.1039/C9OB00198K

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