Issue 39, 2023
From the journal:

Chemical Communications

Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers†

Yibo Zhao,a   Longming Chen,b   Junyi Chen,bc   Jian Li, ORCID logo d   Qingbin Meng, ORCID logo *b   Andrew C.-H. Sue ORCID logo *a  and  Chunju Li ORCID logo *c  

* Corresponding authors

a School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300387, P. R. China
E-mail: andrewsue@xmu.edu.cn

b State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, P. R. China
E-mail: nankaimqb@sina.com

c Tianjin Key Laboratory of Structure and Performance for Functional Molecules, College of Chemistry, Tianjin Normal University, Tianjin 300387, P. R. China
E-mail: cjli@shu.edu.cn

d School of Chemistry and Chemical Engineering, Henan Normal University, P. R. China

Abstract

Herein we report the design and synthesis of a terphen[n]arene derivative functionalised with sulfate acid ester groups. This water-soluble terphen[3]arene host effectively encapsulates a multitude of neuromuscular blocking agents (NMBAs) with high affinity, showing great potential as a NMBAs reversal agent in pharmaceutical research.

Graphical abstract: Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

About
Cited by
Related
Download options Please wait...

Supplementary files

Article information

DOI
https://doi.org/10.1039/D3CC01405C
Article type
Communication
Submitted
22 mars 2023
Accepted
14 avr. 2023
First published
21 avr. 2023

Chem. Commun., 2023,59, 5858-5861

Permissions

Request permissions

Water-soluble terphen[3]arene macrocycle: a versatile reversal agent of neuromuscular blockers

Y. Zhao, L. Chen, J. Chen, J. Li, Q. Meng, A. C.-H. Sue and C. Li, Chem. Commun., 2023, 59, 5858 DOI: 10.1039/D3CC01405C

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements