Ultra-selective, ultra-clean 1D rotating-frame Overhauser effect spectroscopy

Emma L. Gates; Marshall J. Smith; Jonathan P. Bradley; Myron Johnson; Göran Widmalm; Mathias Nilsson; Gareth A. Morris; Ralph W. Adams; Laura Castañar

doi:10.1039/D3CC00550J

Ultra-selective, ultra-clean 1D rotating-frame Overhauser effect spectroscopy†

Emma L. Gates,

^a Marshall J. Smith,

^a Jonathan P. Bradley,

^b Myron Johnson,

^b Göran Widmalm,

^c Mathias Nilsson,

^a Gareth A. Morris,

^a Ralph W. Adams

*^a and Laura Castañar

*^ad

Author affiliations

* Corresponding authors

^a Department of Chemistry, University of Manchester, Oxford Road, Manchester, UK
E-mail: laura.castanaracedo@manchester.ac.uk, ralph.adams@manchester.ac.uk

^b Johnson Matthey, Johnson Matthey Technology Centre, Sonning Common, Blounts Court Road, Reading RG4 9NH, UK

^c Department of Organic Chemistry, Arrhenius Laboratory, Stockholm University, S-106 91 Stockholm, Sweden

^d Department of Organic Chemistry, Faculty of Chemical Science, University Complutense of Madrid, Ciudad Universitaria, 28040 Madrid, Spain
E-mail: lcastana@ucm.es

Abstract

An ultra-selective 1D NMR experiment – GEMSTONE-ROESY – enables clear, unambiguous assignment of ROE signals in the not uncommon situation that traditional selective methods fail. Its usefulness is demonstrated in the analysis of the natural products cyclosporin and lacto-N-difucohexaose I, providing detailed insight into the structures and conformations of these molecules.

This article is part of the themed collection: Celebrating the scientific accomplishments of RSC Fellows

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DOI: https://doi.org/10.1039/D3CC00550J
Article type: Communication
Submitted: 06 Feb 2023
Accepted: 29 Mar 2023
First published: 03 Apr 2023
This article is Open Access

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Chem. Commun., 2023,59, 5854-5857

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Ultra-selective, ultra-clean 1D rotating-frame Overhauser effect spectroscopy

E. L. Gates, M. J. Smith, J. P. Bradley, M. Johnson, G. Widmalm, M. Nilsson, G. A. Morris, R. W. Adams and L. Castañar, Chem. Commun., 2023, 59, 5854 DOI: 10.1039/D3CC00550J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

Chemical Communications

Ultra-selective, ultra-clean 1D rotating-frame Overhauser effect spectroscopy†

Abstract

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Ultra-selective, ultra-clean 1D rotating-frame Overhauser effect spectroscopy

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