Issue 64, 2016
From the journal:

Chemical Communications

Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease†

Joo Hee Jang,‡a   Hoyeon Lee,‡b   Amit Sharma,‡a   Sang Min Lee,b   Tae Hoon Lee,*b   Chulhun Kang*b  and  Jong Seung Kim*a  

* Corresponding authors

a Department of Chemistry, Korea University, Seoul 136-701, Korea
E-mail: jongskim@korea.ac.kr

b The School of East-West Medical Science, Kyung Hee University, Yongin, Korea
E-mail: kangch@khu.ac.kr

Abstract

An indomethacin-guided drug delivery conjugate (IGDDC) has been designed by utilizing cancer associated elevated HDAC and CTSL activities as consecutive demasking ventures for drug activation. IGDDC exhibited preferential uptake by COX-2 positive cells both in vitro and ex vivo highlighting indomethacin’s role in designing new cancer-specific drug delivery frameworks.

Graphical abstract: Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

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Article information

DOI
https://doi.org/10.1039/C6CC04255D
Article type
Communication
Submitted
20 mai 2016
Accepted
08 juil. 2016
First published
08 juil. 2016

Chem. Commun., 2016,52, 9965-9968

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Indomethacin-guided cancer selective prodrug conjugate activated by histone deacetylase and tumour-associated protease

J. H. Jang, H. Lee, A. Sharma, S. M. Lee, T. H. Lee, C. Kang and J. S. Kim, Chem. Commun., 2016, 52, 9965 DOI: 10.1039/C6CC04255D

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