Issue 10, 2022

Bis(cholyl)-based chloride channels with oxalamide and hydrazide selectivity filters

Abstract

We report the development of supramolecular bis(cholyl) ion channels using oxalamide and hydrazide as selectivity filters. The hydrazide system showed superior chloride transport activity to oxalamide via the formation of a barrel stave channel. The better chloride recognition within the hydrazide channel over the oxalalmide channel was confirmed from the theoretical calculations.

Graphical abstract: Bis(cholyl)-based chloride channels with oxalamide and hydrazide selectivity filters

Supplementary files

Article information

Article type
Communication
Submitted
16 oct. 2021
Accepted
07 févr. 2022
First published
08 févr. 2022

Org. Biomol. Chem., 2022,20, 2054-2058

Bis(cholyl)-based chloride channels with oxalamide and hydrazide selectivity filters

R. Sharma, A. Vijay, A. Mukherjee and P. Talukdar, Org. Biomol. Chem., 2022, 20, 2054 DOI: 10.1039/D1OB02028E

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