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Themed collection Recent Review Articles

20 items
Review Article

Thalidomide-type teratogenicity: structure–activity relationships for congeners

Unravelling the molecular basis of thalidomide embryotoxicity, which is remarkably species-specific, is challenging in view of its low toxicity in the mature animal.

Graphical abstract: Thalidomide-type teratogenicity: structure–activity relationships for congeners
From the themed collection: Recent Review Articles
Review Article

Phototoxicity of traditional chinese medicine (TCM)

Phototoxicity can cause toxic responses such as edemas and lesions, and is one of the severe adverse effects that largely limit the use of these phototoxic drugs.

Graphical abstract: Phototoxicity of traditional chinese medicine (TCM)
From the themed collection: Recent Review Articles
Review Article

Maternal SSRIs experience and risk of ASD in offspring: a review

Antidepressants are extensively used during pregnancy and associated with severe outcomes, including innate malformations, prematurity, and low birth weight, etc.

Graphical abstract: Maternal SSRIs experience and risk of ASD in offspring: a review
From the themed collection: Recent Review Articles
Review Article

Cellular and molecular mechanisms of sulfur mustard toxicity on spermatozoa and male fertility

Sulfur mustard (SM) is a toxic compound that can target human spermatozoa.

Graphical abstract: Cellular and molecular mechanisms of sulfur mustard toxicity on spermatozoa and male fertility
From the themed collection: Recent Review Articles
Review Article

Delayed death following paraquat poisoning: three case reports and a literature review

Paraquat (PQ) poisoning is the main medical problem in developing countries and it is spread out worldwide. A similar structure of PQ to MPP+ (1-methyl-4-phenylpyridinium) caused PQ-induced neurotoxicity and injury to renal proximal tubules.

Graphical abstract: Delayed death following paraquat poisoning: three case reports and a literature review
From the themed collection: Recent Review Articles
Review Article

Big-data and machine learning to revamp computational toxicology and its use in risk assessment

The creation of large toxicological databases and advances in machine-learning techniques have empowered computational approaches in toxicology.

Graphical abstract: Big-data and machine learning to revamp computational toxicology and its use in risk assessment
From the themed collection: Recent Review Articles
Open Access Review Article

The association between chemical-induced porphyria and hepatic cancer

The haem biosynthetic pathway is of fundamental importance for cellular metabolism both for the erythroid and nonerythroid tissues.

Graphical abstract: The association between chemical-induced porphyria and hepatic cancer
From the themed collection: Recent Review Articles
Review Article

Role of xenobiotics in the induction and progression of fatty liver disease

Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans.

Graphical abstract: Role of xenobiotics in the induction and progression of fatty liver disease
From the themed collection: Recent Review Articles
Review Article

The safety evaluation of food flavouring substances: the role of metabolic studies

The safety assessment of a flavour substance examines several factors, including metabolic and physiological disposition data.

Graphical abstract: The safety evaluation of food flavouring substances: the role of metabolic studies
From the themed collection: Recent Review Articles
Review Article

Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators

A large number of nongenotoxic chemicals have been shown to increase the incidence of liver tumours in rats and/or mice by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR).

Graphical abstract: Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators
From the themed collection: Recent Review Articles
Review Article

Chromatin dynamics underlying latent responses to xenobiotics

Xenobiotic-induced perturbations of somatic tissue or germline epigenomes may underlie delayed-onset and long-lasting adverse effects.

Graphical abstract: Chromatin dynamics underlying latent responses to xenobiotics
From the themed collection: Recent Review Articles
Review Article

Goodbye to the bioassay

It is time to say goodbye to the standard two-year rodent bioassay.

Graphical abstract: Goodbye to the bioassay
From the themed collection: Recent Review Articles
Review Article

Collaboration and competition: ethics in toxicology

Toxicology has frequently been a focus of scientific and societal concern. It's time to examine practices such as peer review, resourcing, transparency and data sharing to ensure the field stays current, relevant and ethical.

Graphical abstract: Collaboration and competition: ethics in toxicology
From the themed collection: Recent Review Articles
Review Article

Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway

Sensitisation of the respiratory tract to chemicals resulting in respiratory allergy and allergic asthma is an important occupational health problem, and presents toxicologists with no shortage of challenges.

Graphical abstract: Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway
From the themed collection: Recent Review Articles
Review Article

Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action

The CAR-mediated MOA for liver tumorigenesis is of no carcinogenic risk for humans.

Graphical abstract: Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action
From the themed collection: Recent Review Articles
Review Article

The state of bisphenol research in the lesser developed countries of the EU: a mini-review

Bisphenol compounds are a class of chemical epoxy resins that are found throughout the world in food packaging, thermal paper products, dental materials, and more.

Graphical abstract: The state of bisphenol research in the lesser developed countries of the EU: a mini-review
From the themed collection: Recent Review Articles
Review Article

Evaluation of the relevance of DILI predictive hypotheses in early drug development: review of in vitro methodologies vs. BDDCS classification

Drug-induced liver injury (DILI) is a major safety concern; it occurs frequently; it is idiosyncratic; it cannot be adequately predicted; and a multitude of underlying mechanisms has been postulated.

Graphical abstract: Evaluation of the relevance of DILI predictive hypotheses in early drug development: review of in vitro methodologies vs. BDDCS classification
From the themed collection: Recent Review Articles
Review Article

Anticancer, antimicrobial, and analgesic activities of spider venoms

Spider venoms are complex mixtures composed of a variety of compounds, including salts, small organic molecules, peptides, and proteins.

Graphical abstract: Anticancer, antimicrobial, and analgesic activities of spider venoms
From the themed collection: Recent Review Articles
Review Article

Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective

After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity.

Graphical abstract: Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective
From the themed collection: Recent Review Articles
Review Article

The impact of nanomaterial characteristics on inhalation toxicity

Due an increasing use of nanotechnology and a ubiquitous human exposition to airborne nanomaterials, this review underlines the importance of the detailed investigation of NM characteristics and the relations to their toxicologic effects.

Graphical abstract: The impact of nanomaterial characteristics on inhalation toxicity
From the themed collection: Recent Review Articles
20 items

About this collection

Toxicology Research publishes authoritative and insightful review articles covering all aspects of the journal scope. In this collection, we have brought together recent reviews published in the journal– we hope you enjoy reading them.

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