Acetylcysteine in paracetamol poisoning: a perspective of 45 years of use
Matthew and Rumack (200 mg or UK ‘Prescott’ line) and the 150 mg Treatment line, both on log scales.
A review of arsenic exposure and lung cancer
As a well-established human carcinogen, arsenic has increased the risk of lung cancer over the past decades.
Mechanisms of DNA-reactive and epigenetic chemical carcinogens: applications to carcinogenicity testing and risk assessment
Chemicals with carcinogenic activity in either animals or humans produce increases in neoplasia through diverse mechanisms.
Rethinking and new perspectives on cardiotoxicity of traditional Chinese medicine
Traditional Chinese Medicine (TCM) has been commonly used in clinical practice for thousands of years and has made enormous contributions to public health in China.
Thalidomide-type teratogenicity: structure–activity relationships for congeners
Unravelling the molecular basis of thalidomide embryotoxicity, which is remarkably species-specific, is challenging in view of its low toxicity in the mature animal.
Phototoxicity of traditional chinese medicine (TCM)
Phototoxicity can cause toxic responses such as edemas and lesions, and is one of the severe adverse effects that largely limit the use of these phototoxic drugs.
Maternal SSRIs experience and risk of ASD in offspring: a review
Antidepressants are extensively used during pregnancy and associated with severe outcomes, including innate malformations, prematurity, and low birth weight, etc.
Cellular and molecular mechanisms of sulfur mustard toxicity on spermatozoa and male fertility
Sulfur mustard (SM) is a toxic compound that can target human spermatozoa.
Delayed death following paraquat poisoning: three case reports and a literature review
Paraquat (PQ) poisoning is the main medical problem in developing countries and it is spread out worldwide. A similar structure of PQ to MPP+ (1-methyl-4-phenylpyridinium) caused PQ-induced neurotoxicity and injury to renal proximal tubules.
Big-data and machine learning to revamp computational toxicology and its use in risk assessment
The creation of large toxicological databases and advances in machine-learning techniques have empowered computational approaches in toxicology.
The association between chemical-induced porphyria and hepatic cancer
The haem biosynthetic pathway is of fundamental importance for cellular metabolism both for the erythroid and nonerythroid tissues.
Role of xenobiotics in the induction and progression of fatty liver disease
Non-alcoholic fatty liver disease is a major cause of chronic liver pathology in humans.
The safety evaluation of food flavouring substances: the role of metabolic studies
The safety assessment of a flavour substance examines several factors, including metabolic and physiological disposition data.
Human relevance of rodent liver tumour formation by constitutive androstane receptor (CAR) activators
A large number of nongenotoxic chemicals have been shown to increase the incidence of liver tumours in rats and/or mice by a mode of action (MOA) involving activation of the constitutive androstane receptor (CAR).
Chromatin dynamics underlying latent responses to xenobiotics
Xenobiotic-induced perturbations of somatic tissue or germline epigenomes may underlie delayed-onset and long-lasting adverse effects.
Goodbye to the bioassay
It is time to say goodbye to the standard two-year rodent bioassay.
Collaboration and competition: ethics in toxicology
Toxicology has frequently been a focus of scientific and societal concern. It's time to examine practices such as peer review, resourcing, transparency and data sharing to ensure the field stays current, relevant and ethical.
Skin and respiratory chemical allergy: confluence and divergence in a hybrid adverse outcome pathway
Sensitisation of the respiratory tract to chemicals resulting in respiratory allergy and allergic asthma is an important occupational health problem, and presents toxicologists with no shortage of challenges.
Case examples of an evaluation of the human relevance of the pyrethroids/pyrethrins-induced liver tumours in rodents based on the mode of action
The CAR-mediated MOA for liver tumorigenesis is of no carcinogenic risk for humans.
The state of bisphenol research in the lesser developed countries of the EU: a mini-review
Bisphenol compounds are a class of chemical epoxy resins that are found throughout the world in food packaging, thermal paper products, dental materials, and more.
Evaluation of the relevance of DILI predictive hypotheses in early drug development: review of in vitro methodologies vs. BDDCS classification
Drug-induced liver injury (DILI) is a major safety concern; it occurs frequently; it is idiosyncratic; it cannot be adequately predicted; and a multitude of underlying mechanisms has been postulated.
Anticancer, antimicrobial, and analgesic activities of spider venoms
Spider venoms are complex mixtures composed of a variety of compounds, including salts, small organic molecules, peptides, and proteins.
Paracetamol metabolism, hepatotoxicity, biomarkers and therapeutic interventions: a perspective
After over 60 years of therapeutic use in the UK, paracetamol (acetaminophen, N-acetyl-p-aminophenol, APAP) remains the subject of considerable research into both its mode of action and toxicity.
The impact of nanomaterial characteristics on inhalation toxicity
Due an increasing use of nanotechnology and a ubiquitous human exposition to airborne nanomaterials, this review underlines the importance of the detailed investigation of NM characteristics and the relations to their toxicologic effects.
About this collection
Toxicology Research publishes authoritative and insightful review articles covering all aspects of the journal scope. In this collection, we have brought together recent reviews published in the journal– we hope you enjoy reading them.