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Themed collection Immunological Biomaterials

11 items
Editorial

Themed collection on immunological biomaterials: where materials meet the immune system in health and diseases

Guest editor Krishnendu Roy introduces this Journal of Materials Chemistry B themed collection on immunological biomaterials.

Graphical abstract: Themed collection on immunological biomaterials: where materials meet the immune system in health and diseases
From the themed collection: Immunological Biomaterials
Review Article

Materials design at the interface of nanoparticles and innate immunity

Engineered nanoparticle platforms have been developed intensely in recent years, yielding significantly broadened applications from interrogating novel biology to new therapies. Using these platforms requires improved understanding of design rules to improve our ability to control nanoparticle-immune system interactions.

Graphical abstract: Materials design at the interface of nanoparticles and innate immunity
From the themed collection: Immunological Biomaterials
Review Article

Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy

Host body response to a foreign medical device plays a critical role in defining its fate post implantation.

Graphical abstract: Tailoring biomaterial surface properties to modulate host-implant interactions: implication in cardiovascular and bone therapy
From the themed collection: Immunological Biomaterials
Review Article

Glycomaterials for immunomodulation, immunotherapy, and infection prophylaxis

Synthetic carbohydrate-modified materials that can engage the innate and adaptive immune systems are receiving increasing interest to confer protection against onset of future disease, such as pathogen infection, as well as to treat established diseases, such as autoimmunity and cancer.

Graphical abstract: Glycomaterials for immunomodulation, immunotherapy, and infection prophylaxis
From the themed collection: Immunological Biomaterials
Review Article

Strategies for modulating innate immune activation and protein production of in vitro transcribed mRNAs

This review discusses the challenges associated with IVT mRNA therapeutics and vaccines as well as the current strategies employed to overcome these challenges.

Graphical abstract: Strategies for modulating innate immune activation and protein production of in vitro transcribed mRNAs
From the themed collection: Immunological Biomaterials
Review Article

Biomolecular strategies to modulate the macrophage response to implanted materials

Materials engineered to display immunomodulatory molecules including adhesion ligands, cytokines, and self-proteins, target receptors on immune cells to modulate their response to biomaterial implants.

Graphical abstract: Biomolecular strategies to modulate the macrophage response to implanted materials
Paper

Self-assembled hybrid supraparticles that proteolytically degrade tumor necrosis factor-α

The strategies of pathogens to evade the human immune system are highly sophisticated and modulate a variety of inflammatory pathways.

Graphical abstract: Self-assembled hybrid supraparticles that proteolytically degrade tumor necrosis factor-α
From the themed collection: Immunological Biomaterials
Paper

Peptide nanofiber–CaCO3 composite microparticles as adjuvant-free oral vaccine delivery vehicles

To combat mucosal pathogens that cause gastrointestinal (GI) infections, local mucosal immunity is required which is best achieved through oral vaccination.

Graphical abstract: Peptide nanofiber–CaCO3 composite microparticles as adjuvant-free oral vaccine delivery vehicles
From the themed collection: Immunological Biomaterials
Paper

The effect of PEGylation on the stimulation of IL-1β by gold (Au) nanoshell/silica core nanoparticles

PEGylation of Au nanoshell/silica core (GNS) particles reduces the aggregation in cell culture and the generation of IL-1β and the influx of neutrophils in the mouse peritoneal cavity.

Graphical abstract: The effect of PEGylation on the stimulation of IL-1β by gold (Au) nanoshell/silica core nanoparticles
Paper

Triamcinolone–carbon nanotube conjugation inhibits inflammation of human arthritis synovial fibroblasts

Repetitive intra-articular corticosteroid injections are inevitable for treating synovial inflammation in advanced arthritis.

Graphical abstract: Triamcinolone–carbon nanotube conjugation inhibits inflammation of human arthritis synovial fibroblasts
From the themed collection: Immunological Biomaterials
Paper

A cell-based microarray to investigate combinatorial effects of microparticle-encapsulated adjuvants on dendritic cell activation

Experimental vaccine adjuvants are being designed to target specific toll-like receptors (TLRs) alone or in combination, expressed by antigen presenting cells, notably dendritic cells (DCs).

Graphical abstract: A cell-based microarray to investigate combinatorial effects of microparticle-encapsulated adjuvants on dendritic cell activation
From the themed collection: Immunological Biomaterials
11 items

About this collection

Although biomaterial scientists have been working at the interface of immunology, inflammation and materials for decades, recent advances in our understanding of how the immune system initiates, modulates and ameliorates almost every disease has opened up new directions in materials research that are targeted to immune-modulation. This themed issue focuses on a wide range of topics, including but not limited to the design or modification of biomaterials to control inflammation, modulate vaccine responses, deliver immunotherapeutics, enhance transplantation outcomes, augment regenerative potential and wound healing, and longitudinally detect immune-related biomarkers.

This themed issue was guest edited by Professor Krishnendu Roy, Georgia Institute of Technology, USA.

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