Themed collection Journal of Materials Chemistry B HOT Papers

Butyrylcholinesterase (BChE) is a human serine hydrolase, which plays critical roles in various physiological and pathological states. Here, we summarized the optical probes that can selectively monitor the BChE activity in different biological models.

The ability to detect and visualize cellular events and associated biological analytes is essential for the understanding of their physiological and pathological functions.

Different organelle-staining behaviors of OQ and PQ, and intracellular translocation of OQ caused by the changes of CMP and MMP.

The tetramethylpyrazine-loaded conductive hydrogel could diminish the breakdown of the blood–spinal cord barrier and protect against neuronal cell death to synergistically restore neurological functions post spinal cord injury.

We explored a new way of utilizing the ESP difference to improve the molecular packing of (A–D–A) type molecules, and obtained a series of NIR PTAs with good PTT performance. The in vivo antitumor study demonstrates effective suppression of tumors.

Enhancing the antibacterial properties by regulating valence configurations of copper: a focus on Cu-carboxyl chelates.

The study focused on the fine refinement of PNIPAM-based materials, resulting in enhanced biocompatibility and drug loading for a smart hydrogel system with multi-responsive 5-FU release.

Drug-loaded composite hydrogel microspheres HAMA@Lipo@CyA (HLC) alleviate osteoarthritis by suppressing inflammation and restoring the cartilage matrix.

A defect-rich hollow Schottky heterojunction sonosensitizer, constructed by defect engineering and noble metal enrichment, exhibits an amplified treatment effect for sonodynamic therapy due to the inhibition effect of electron–hole pair recombination.

Material repurposing is proposed where the performance of carbonyl iron powder (CIP), a nutritional intervention agent of iron supplement approved by the US FDA for iron deficiency anemia in clinic, was explored in anti-cancer treatment.

pH/ROS/glucose triple-responsive OAH@TA hydrogel elicits controlled TA release, enhancing antibacterial, anti-inflammatory, and antioxidative properties to facilitate diabetic wound healing.

The tailored nanomedicine 5-FU-LA@PPL could selectively combat Fn, inhibit autophagy in CRC cells, restore chemosensitivity of 5-FU as well as OxPt, and consequently enhance the combination chemotherapy effects for Fn-associated drug-resistant CRC.

SaRNA was formulated with six different polymer carriers to generate saRNA-polyplexes. After screening for transfection efficiency, compared to a lipid-based standard, the best performing ones were characterized in detail and administered to mice.

Aryl functioned S-rhodamines were presented as mitochondrion-targeted photosensitizers with different photodynamic therapy activities.

Nanoparticles identifying bacteria and forming a bacterial extracellular trap (BET). LPS induced in situ transformation and self-assembly of BET nanoparticles were shown to trap Gram-negative bacteria.

Schematic diagram of the preparation process of P(APM/MPC)-OCS-BP and the function model of P(APM/MPC)-OCS-BP with anti-coagulation, anti-calcification, and anti-inflammatory properties and a high capacity to promote endothelial proliferation.

Schematic diagram of the preparation of the enzyme-responsive nanoplatform HA-CP@Fe₃O₄ and its application in the study of antibacterial infection in vivo.

An X-ray responsive RCNprotac with enhanced tumor accumulation for BRD4 proteolysis and enhanced radiosensitization is reported.

Nanotheranostics (IN-DPPCO NPs) based on a conjugated polymer IN-DPP and a carbon monoxide (CO) carrier polymer mPEG(CO) are reported for H₂O₂-triggered controllable carbon monoxide delivery for photothermal augmented gas therapy.

A dual-targeted contrast agent, RGD-(DOTA-Gd)-TPP (RDP), was synthesized, in which RGD is used to target the α_vβ₃ integrin receptor overexpressed in tumor cells and TPP is used to bind to a mitochondrion further.

Here, we designed and synthesized two donor–acceptor (D–A) conjugated polymers with DPP as the receptor. The polymer nanoparticles have broad application prospects in biological imaging and photothermal therapy.

A series of subcellular targeted probes with hypersensitivity (reaction time <60 s, detection limit at the nmol level) to nitric oxide (NO) were developed to map NO fluctuations at the subcellular level.

An injectable photocurable hydrogel based on methacrylated dopamine and silk fibroin constructs an antioxidant protein microenvironment, which prevents oxidative stress in vitro, and promotes collagen disposition and angiogenesis in vivo.

The endoplasmic reticulum (ER) and lipid droplets (LDs) intricately interact in cellular processes, with the ER serving as a hub for lipid synthesis and LDs acting as storage organelles for lipids.

Mg-based implants with a sandwiched coating simultaneously facilitate antibacterial and osteogenic properties due to the synergistic biological effects of TCS and Mg²⁺.

Design factors of PEGylated polyion complex (PIC) nanoparticles, particularly PIC vesicles, were examined regarding polyion chain matching, domain crosslinking, and chemical modification of charged units, to modulate mammalian cell-PIC interaction.

Endogenous O₂ can be continuously generated by the catalysis of Ce in the lattice of CeO₂ to enhance ¹O₂ production via a type II PDT (energy transfer), and many other ROS (such as O₂⁻ and ·OH) can be produced via a type I PDT (electron transfer).

A series of pH-responsive and sulfobetaine-incorporated micelles with positive charges is prepared, in which the effects of the sulfobetaine incorporation displayed different profiles in the blood behaviours, phagocytosis, and in vivo biodistribution.

A schematic of the fabrication of FePt-DAC/NC@HA and synergistic chemodynamic therapy and photothermal therapy for tumor catalytic therapy.

A bR-based wearable pH biometer is fabricated to monitor infected wound. Under illumination, bR generate a positive photovoltage (V_p) and negative photovoltage (V_n), and the ratio (V_n/V_p) present a linear relationship in the pH range of 4.0–10.0.

Antibacterial nanocomposite-integrated microneedles were designed for infected diabetic wound therapy. The nanocomposite could be destroyed by high glucose and exerted a powerful and synergistic antibacterial effect against bacterial infections.

The clinical use of protein and peptide biotherapeutics requires fabrication of stable products.

An endoplasmic reticulum-targetable ratiometric probe for imaging the fluctuation of HOBr during ER stress was successfully developed.

A photocurrent-polarity-switching photoelectrochemical (PEC) biosensor was developed for the ultrasensitive detection of tobramycin (TOB) through bipedal DNA walker amplification using a laser-induced zinc oxide/graphene (ZnO/LIG) photoelectrode.

PFOB-NEs incorporate O₂, enabling sustained and continuous release for 36 hours. We investigate their potential for creating a favorable environment for hair regrowth.