Themed collection 2017 Journal of Materials Chemistry B HOT Papers
Research progresses on the functional polypeptides in the detection and imaging of breast cancer
Polypeptides as functional groups continue to garner significant interest in the detection and imaging of breast cancer, working as recognition elements, signal sources, building blocks and therapeutic reagents, etc.
Understanding energy transfer with luminescent gold nanoclusters: a promising new transduction modality for biorelated applications
AuNCs engage in energy transfer by a non-Förster process although many of the same photophysical requirements are needed.
Cultured cell-derived decellularized matrices: a review towards the next decade
Summary of recent progress in cell-derived decellularized matrices preparation and application, with perspectives towards the next decade.
Thermo-responsive polymers and their application as smart biomaterials
This review summarises smart thermo-responsive polymeric materials with reversible and ‘on–off’ remotely switchable properties for a wide range of biomedical and biomaterials applications.
Physical principles of graphene cellular interactions: computational and theoretical accounts
Clarifying the physical principles of graphene cellular interactions is critical for the wider application of graphene-based nanomaterials in nanomedicine. This review highlights the advances in computational and theoretical accounts for this emerging field.
Engineering strategies for chitin nanofibers
Chitin nanofibers are the fundamental building blocks of numerous structural natural materials. From top-down to bottom-up, here we review engineering strategies to produce chitin nanofibers for engineered materials and their applications.
Weak bond-based injectable and stimuli responsive hydrogels for biomedical applications
Here we define hydrogels crosslinked by weak bonds as physical hydrogels.
Targeting fibronectin for cancer imaging and therapy
During cancer progression, the extracellular matrix (ECM) undergoes dramatic changes, which promote cancer cell migration and invasion.
Cyclodextrin-based supramolecular nanoparticles for biomedical applications
This review on cyclodextrin-based supramolecular nanoparticles presents the different forces involved in particle formation and their diagnostic and therapeutic applications.
Shaped stimuli-responsive hydrogel particles: syntheses, properties and biological responses
This review summarizes a pool of current experimental approaches and discusses perspectives in the development of the synergistic combination of shape and stimuli-response in particulate hydrogels.
Direct ratiometric detection of nitric oxide with Cu(II)-based fluorescent probes
We report the first Cu(II)-based ratiometric sensors for direct, rapid, and selective fluorescent detection of nitric oxide.
L-Carnitine derived zwitterionic betaine materials
L-CarnitineMA is the first zwitterionic betaine monomer from natural feedstocks, exhibiting superior anti-fouling performance.
Temporal and spatial programming in soft composite hydrogel objects
A spatial and temporal response of hydrogel objects is demonstrated using an enzyme as a programming tool.
Natural extracted aerogels with inherent anisotropy and their 3D printing assisted biomedical applications
Exemplified with jackfruit and sugarcane, natural extracted aerogels with inherent structural anisotropy were investigated for the first time.
Micro/nano-imprinted substrates grafted with a thermoresponsive polymer for thermally modulated cell separation
Thermoresponsive convex or concave substrates were developed as functional cell separation materials by the combination of thermal nano-imprinted lithography and subsequent surface-initiated ATRP of PIPAAm.
Macrophage responses to the physical burden of cell-sized particles
The role of physical burden on macrophage functions was revealed by exploiting an “intake method” and uniform autofluorescent cell-sized particles.
Monitoring the release of a NO photodonor from polymer nanoparticles via Förster resonance energy transfer and two-photon fluorescence imaging
Polymer nanoparticles entrapping a NO photodonor are designed to monitor its release in human skin samples through two-photon fluorescence imaging.
Photocontrolled protein assembly for constructing programmed two-dimensional nanomaterials
A rapid and efficient strategy was developed to construct photocontrolled 2D protein nanosheets with an orderly arrangement.
Tanshinones inhibit hIAPP aggregation, disaggregate preformed hIAPP fibrils, and protect cultured cells
Tanshinones act as common inhibitors to inhibit the aggregation of both hIAPP and Aβ, disaggregate preformed hIAPP and Aβ amyloid fibrils, and protect cells from hIAPP- and Aβ-induced toxicity.
Mission ImPOxable – or the unknown utilization of non-toxic poly(2-oxazoline)s as cryoprotectants and surfactants at the same time
Polymeric nanoparticles are produced using hydrophilic poly(2-oxazoline)s (P(Ox)s) as particle stabilizers during preparation, purification and lyophilization as an all-in-one system.
Photo-crosslinked mono-component type II collagen hydrogel as a matrix to induce chondrogenic differentiation of bone marrow mesenchymal stem cells
Type II collagen methacrylamide with a triple helix was developed for 3D construction of a cartilaginous ECM-like microenvironment to induce chondrogenic differentiation of BMSCs.
In vitro degradation behavior of a hydroxyapatite/poly(lactide-co-glycolide) composite reinforced by micro/nano-hybrid poly(glycolide) fibers for bone repair
A poly(glycolide) (PGA) fiber-reinforced hydroxyapatite/poly(lactide-co-glycolide) (HA/PLGA) composite with high mechanical strength has been prepared previously.
Zinc ion mediated synthesis of cuprous oxide crystals for non-enzymatic glucose detection
Zn2+ was used to mediate the fabrication of Cu2O crystals with different glucose sensing performances depending on their structures.
Hydrogen bonding induced protein adsorption on polymer brushes: a Monte Carlo study
The protein adsorption behaviors on polymer brushes in the presence of hydrogen bonding between proteins and polymer brushes.
Development of a dual drug-loaded hydrogel delivery system for enhanced cancer therapy: in situ formation, degradation and synergistic antitumor efficiency
A stimuli-responsive, biodegradable, and dual drug-loaded hydrogel delivery system was formed in situ for combination drug therapy of cancer in vivo.
NIR light-activated dual-modality cancer therapy mediated by photochemical internalization of porous nanocarriers with tethered lipid bilayers
Tethered lipid bilayers on porous nanocarriers facilitate photochemical internalization and efficient cancer therapy via NIR irradiation.
A dendritic catiomer with an MOF motif for the construction of safe and efficient gene delivery systems
The dendritic catiomer using biocompatible Zr-MOFs as the core exhibited a markedly higher transfection efficiency and lower cytotoxicity than the commercial gold standard branched PEI25k in A549 cells.
Pristine carbon nanotube scaffolds for the growth of chondrocytes
The effective growth of chondrocytes and the formation of cartilage is demonstrated on scaffolds of aligned carbon nanotubes.
InP/ZnSe/ZnS quantum dots with strong dual emissions: visible excitonic emission and near-infrared surface defect emission and their application in in vitro and in vivo bioimaging
Unique oil-soluble InP/ZnSe/ZnS QDs with strong visible excitonic and NIR surface defect emissions were synthesized and used in multi-scale bioimaging.
Multilayered upconversion nanocomposites with dual photosensitizing functions for enhanced photodynamic therapy
The dual-photosensitizer upconversion nanoplatform takes advantage of upconversion luminescence and generates singlet oxygen and free radicals for enhanced photodynamic therapy.
The development of cell-initiated degradable hydrogel based on methacrylated alginate applicable to multiple microfabrication technologies
A cell-initiated degradable hydrogel based on methacrylated alginate was developed for 3D microfeatures construction to meet the demand of molding and biomimetic function requirement.
Enhanced cell uptake of fluorescent drug-loaded nanoparticles via an implantable photothermal fibrous patch for more effective cancer cell killing
Great efforts have been devoted to effective delivery of therapeutics into cells for cancer therapy.
A tumour microenvironment-responsive polymeric complex for targeted depletion of tumour-associated macrophages (TAMs)
A dual-level targeting polymeric system to eliminate tumour-associated macrophages.
Silicate-based bioceramics regulating osteoblast differentiation through a BMP2 signalling pathway
Si-containing bioactive ionic products released from silicate-based bioceramics activate Smad1/5-mediated BMP2 signaling pathways.
Implementation of a stratified approach and gene immobilization to enhance the osseointegration of a silk-based ligament graft
Integration of a stratified approach and gene immobilization promotes silk-based ACL interface formation, expanding the therapeutic potential of a silk-based ligament graft.
An injectable supramolecular self-healing bio-hydrogel with high stretchability, extensibility and ductility, and a high swelling ratio
Reversible networks are a key factor for designing self-healing hydrogels with high stretching properties.
Preparation of dexamethasone-loaded calcium phosphate nanoparticles for the osteogenic differentiation of human mesenchymal stem cells
Dexamethasone (DEX)-loaded biphasic calcium phosphate nanoparticles (BCP-NPs) are prepared by incorporation of DEX during or after the formation of BCP-NPs. The DEX-loaded BCP-NPs release DEX in a sustained manner and enhance the osteogenic differentiation of hMSCs.
Breaking the reduced glutathione-activated antioxidant defence for enhanced photodynamic therapy
Photodynamic therapy (PDT) has been applied in cancer treatment by utilizing reactive oxygen species (ROSs) to kill cancer cells.
Multifunctional Cu39S28 hollow nanopeanuts for in vivo targeted photothermal chemotherapy
This work represents a one-step direct aqueous method to synthesize Cu39S28 hollow nanopeanuts towards ultrasensitive tumor targeted photothermal chemotherapy.
Construction of giant glycosidase inhibitors from iminosugar-substituted fullerene macromonomers
A dramatic enhancement in the glycosidase multivalent inhibitory effect was observed while going from a dodecavalent iminosugar ball to the corresponding giant molecule with 120 peripheral subunits.
Effect of hydrogel material composition on hBMSC differentiation into zone-specific neo-cartilage: engineering human articular cartilage-like tissue with spatially varying properties
Material composition alone can be used to direct human bone marrow stromal cells into distinct, zone-specific cell phenotypes and spatially-varying, multi-layered material scaffolds can generate complex, patterned tissue structures.
Stacking modular DNA circuitry in cascading self-assembly of spherical nucleic acids
Integrated circuitries are successfully built through using the cascaded modular strategy with the assistance of stochastic simulations.
Facile fabrication of a resveratrol loaded phospholipid@reduced graphene oxide nanoassembly for targeted and near-infrared laser-triggered chemo/photothermal synergistic therapy of cancer in vivo
A resveratrol-loaded phospholipid coated reduced graphene oxide was prepared using a sonication method.
Influence of microporous gelatin hydrogels on chondrocyte functions
Gelatin hydrogels with microporous structures were prepared by polymerization of GelMAGMA macromers and dissolution of gelatin hydrogel microcubes. The microporous gelatin hydrogels promoted proliferation of chondrocytes and showed different cellular effects compared to hydrogels without microporous structures.
A novel transparent luminous hydrogel with self-healing property
A Luminous hydrogel with self-healing properties and biocompatibility was synthesized by a Eu-containing PVA with boric acid as a cross-linking agent.
Conducting hydrogels for edible electrodes
Conducting hydrogels prepared from edible, commercially available materials were shown to function as capacitive pressure sensors.
Cation-driven luminescent self-assembled dots of copper nanoclusters with aggregation-induced emission for β-galactosidase activity monitoring
The self-assembly of CuNCs was driven by aluminum cations and they had a sensing application in the monitoring of β-galactosidase activity.
Chondrogenic differentiation of BMSCs encapsulated in chondroinductive polysaccharide/collagen hybrid hydrogels
Although BMSC-based therapy is one of the most front-line technologies for cartilage repair, it is still a big challenge to attain ideal niches for BMSC chondrogenic differentiation.
A core–shell structured polyplex for efficient and non-toxic gene delivery
We developed a core–shell polyplex with minimal high generation dendrimer to condense DNA and low-molecular-weight linear polyethylenimine coated on the core. The polyplex represented both high transfection efficacy and low toxicity.
RGD/CTX-conjugated multifunctional Eu–Gd2O3 NRs for targeting detection and inhibition of early tumor
The multifunctional Eu–Gd2O3 nanorods (NRs) with targeting/limitation of early glioblastoma and enhancements of in vivo MR and luminescence imaging were fabricated through a hydrothermal-calcination, PEGylation and thiolation conjugation of arginine–glycine–aspartic (RGD) and chlorotoxin (CTX).
Localized multidrug co-delivery by injectable self-crosslinking hydrogel for synergistic combinational chemotherapy
The multidrug co-loaded injectable hydrogels against tumor showed superiority and potential application values.
A porous sodium polyacrylate-grafted chitosan xerogel for severe hemorrhage control synthesized from one-pot reaction
In this study, we fabricated a SPA-co-CTS sponge and demonstrated a fast and powerful hemostatic effect both in vitro and in vivo, which was a promising first-aid device for severe hemorrhage control.
Lanthanide-doped LaOBr nanocrystals: controlled synthesis, optical spectroscopy and bioimaging
A new bioprobe based on lanthanide-doped LaOBr NCs exhibiting distinct upconversion/downshifting luminescence was explored and demonstrated for in vitro cancer cell imaging.
A label-free visual platform for self-correcting logic gate construction and sensitive biosensing based on enzyme-mimetic coordination polymer nanoparticles
We proposed a label-free visual platform based on Cu–GMP CPNs for both self-correcting molecular logic gate construction and sensitive biosensing.
Enhancement of synergistic gene silencing by RNA interference using branched “3-in-1” trimer siRNA
Nanostructured RNA carrying three different siRNAs was assembled to silence three target genes (Axin, APC, and GSK-3β) in the Wnt/β-catenin signaling pathway. This nanostructured ‘3-in-1’ siRNA showed high activity at a low concentration due to the long-term resistance, and enhancing the effect of RNA interference.
Albumin-mediated platinum nanocrystals for in vivo enhanced computed tomography imaging
Albumin-mediated ultrasmall platinum nanocrystals were fabricated for both in vitro and in vivo enhanced computed tomography imaging.
N,S co-doped carbon dots as a stable bio-imaging probe for detection of intracellular temperature and tetracycline
N,S-CDs display an unambiguous bioimaging ability in the detection of intracellular temperature and tetracycline with satisfactory results.
Extracellular matrix powder from cultured cartilage-like tissue as cell carrier for cartilage repair
Efficiently cultivating cartilage decellularized matrix powder by a 3D culture method for cartilage repair in rabbit osteochondral defects.
Injectable bioactive akermanite/alginate composite hydrogels for in situ skin tissue engineering
Injectable bioactive SA/Aker hydrogels formed by crosslinking of bioactive ions, which recruit stem cells and enhance skin regeneration.
Phycocyanin-based nanocarrier as a new nanoplatform for efficient overcoming of cancer drug resistance
The rational design of a novel phycocyanin-based nanosystem with bio-responsive properties to achieve prolonged blood circulation and overcome drug resistance without causing systemic toxicity.
Hybrid inhalable microparticles for dual controlled release of levofloxacin and DNase: physicochemical characterization and in vivo targeted delivery to the lungs
Current medical treatments against recurrent pulmonary infections caused by Pseudomonas aeruginosa, such as cystic fibrosis (CF) disorder, involve the administration of inhalable antibiotics.
A biophysical study of gene nanocarriers formed by anionic/zwitterionic mixed lipids and pillararene polycationic macrocycles
A multivalent cationic macrocycle is used as a mediator between plasmid DNAs and anionic lipids (ALs) to build an efficient and safe gene nanocarrier.
A two-photon fluorescent probe for viscosity imaging in vivo
A quinoline-based two-photon fluorescent probe (MCN) was developed for viscosity imaging in vivo.
808 nm near-infrared light controlled dual-drug release and cancer therapy in vivo by upconversion mesoporous silica nanostructures
A dual-drug co-delivery and 808 nm NIR photo-controlled release system can control drug release behaviour and enhance anticancer efficacy.
A patterned nanocomposite membrane for high-efficiency healing of diabetic wound
A bioactive glass/patterned electrospun membrane (BG/PEM) with uniform nanostructure could stimulate angiogenesis and accelerate diabetic wound healing with high efficiency.
Large-area assembly of halloysite nanotubes for enhancing the capture of tumor cells
Here, polystyrene sulfonate sodium (PSS) modified halloysite nanotubes were self-assembled into patterned coating on a glass substrate with ordered nanotube arrays for capture of tumor cells.
The hypothermic preservation of mammalian cells with assembling extracellular-matrix-mimetic microparticles
The reversible assembly of magnetic alginate microparticles could mimic the extracellular matrix for efficient and facile hypothermic cell preservation.
A multifunctional polyethylenimine-based nanoplatform for targeted anticancer drug delivery to tumors in vivo
Polyethylenimine can be modified with folic acid through a polyethylene glycol spacer for targeted anticancer drug delivery to tumors.
Sub-10 nm gold nanoparticles promote adipogenesis and inhibit osteogenesis of mesenchymal stem cells
Sub-10 nm Au NPs with an average size of 4 nm (Au4-mPEG NPs) had a promotive effect on the adipogenic differentiation and an inhibitive effect on the osteogenic differentiation of human bone marrow-derived mesenchymal stem cells (hMSCs) due to the highly induced ROS level.
Sonochemically-fabricated Ga@C-dots@Ga nanoparticle-aided neural growth
In this paper, we report the fabrication of an antibacterial material, Ga-doped C-dots on Ga nanoparticles (Ga@C-dots@Ga NPs), which is deposited on a glass substrate for neural growth.
About this collection
This on-going web collection features all the articles published inJournal of Materials Chemistry B in 2017 marked as HOT, as recommended by referees. Congratulations to all the authors whose articles are featured!