Themed collection Biomedical Polymer Materials

The structure–property relationship of polyprodrugs was explored from the perspective of molecular structure, by discussing the effects of the conjugations and linkers on their drug content and drug releasing performance.

The applications of renal-targeting natural polymers and polymer-delivered natural drugs for the treatment of lethal acute kidney injury are summarized.

Recent progress in nanomaterials for bacteria-related tumor therapy in terms of chemotherapy, immunotherapy and synergistic therapy is summarized in this review in order to provide some insights into this emerging and rapidly growing research area.

Blood–brain barrier-crossing dendrimers for glioma imaging diagnostics, chemotherapy, gene therapy, or imaging-guided therapy have been concisely reviewed with perspectives briefly discussed.

We summarize the advancements of renal-clearable organic nanoprobes for optical imaging and remote urinalysis. The versatile design strategies are discussed along with their challenges and perspectives for the development of next-generation renal-clearable nanoprobes.

Organic–inorganic composite hydrogels, with its polymeric networks interacting with inorganic fillers via different modes, provide a versatile platform for regenerative medicine.

Amine-epoxide ring-opening polymerization was carried out to construct a hydroxyl-rich branched polycation and based on a one-pot strategy for the flexible introduction and multifunctional modification of responsive molecules.

Facile conjugation of chlorambucil with IR775 chloride can afford IR775-Cbl with mitochondria-targeting potency for tumor cells, exhibiting distinct “1 + 1 > 2” tumor inhibition.

A ROS-responsive hydrogel was developed as a platform for co-delivery of a chemotherapeutic drug (DOX), an immunological adjuvant (R848) and an ICB antibody (aPD-1) for combination tumor therapy and prevention of post-operative tumor recurrence.

Col modification significantly enhanced the tumor penetration and therapy efficacy of multiarm polymer-based nanomedicines.

Bovine serum albumin (BSA) regulates cellular internalization of charged ureido-pyrimidinone (UPy)-assembly. The BSA-bond UPy-assembly can be internalized and co-localizes with mitochondria. Without BSA, the UPy-assembly anchors to the cell membrane.

Intracerebral haemorrhage (ICH) is a devastating neurovascular attack with limited treatment options.

A siRNA delivery system was developed using clinically approved mPEG-b-PLGA, cationic lipid and ionizable lipid for siRNA delivery and cancer immunotherapy.

This article demonstrates an inverse emulsion scheme to polymerize a variety of ionizable and non-ionizable monomers to form stimuli-responsive nanoparticles with potential applications in biomaterials science.

Soybean agglutinin-derived glycopeptide-introduced pH-responsive polysaccharide-modified liposomes promote the cross-presentation and induction of antigen-specific cellular immune responses.

This study presents a novel hyaluronic acid (HA)-based nanoparticles with dual effects for osteoarthritis (OA) treatment, combining anti-inflammatory effects through nitric oxide (NO) scavenging and lubrication effect provided by HA.

Chol-PEG and Qua-PLL were self-assembled with a Cas9/PLK1 sgRNA ribonucleoprotein to form a ternary nanoparticle QNP/RNP_PLK1 for efficient cancer therapy.

A wound microenvironment regulatory poly(L-glutamic acid) composite hydrogel can promote cell proliferation, migration, and angiogenesis, alleviate inflammation and polarize pro-inflammatory M1 macrophages into pro-healing M2 macrophages, thus accelerating wound healing.

The rifampicin-loaded HPUs-QA nanoassembly (HPUs-Rif/QA) demonstrated a synergistic antimicrobial effect in killing planktonic bacteria and eradicating the corresponding biofilms.

We present a biocompatible, controllably degradable, and functionalizable zwitterion-albumin hybrid hydrogel with long-term resistance against foreign body responses.

Novel nano-in-nano coaxial platform for enteric protein delivery.

A transdermal drug delivery system based on PVA/F-BPA microneedles for BNCT of melanoma.

Phosphorus core–shell tecto dendrimers with rigid cores enable enhanced fluorescence/SPECT dual-mode tumor imaging likely through an amplified enhanced permeability and retention effect.

A soft, non-setting and degradable periodontal dressing with biodegradability was developed using sodium carboxymethyl cellulose, Eudragit S 100 and povidone K30. The periodontal dressings could promote mucosal wound healing.

We develop single-molecule dual-imaging nanodots by divergent growth for fluorescence and MR imaging of surface chemistry-dependent tumor entrance. The results show that the surface chemistry of nanoparticles can dominate the ways of tumor entrance.

A systematic analysis is presented, highlighting the unique properties of Eudragits as additive in mucoadhesive hydrogels for ocular protein delivery.

A biodegradable COF was constructed to break in response to tumors, enhancing the therapeutic effect on tumors.