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Themed collection 2014 Journal of Materials Chemistry B Hot Articles

38 items
Highlight

The role of material structure and mechanical properties in cell–matrix interactions

Cellular interactions with the extracellular matrix (ECM) are of fundamental importance in many normal and pathological biological processes, including development, cancer, and tissue homeostasis, healing and regeneration.

Graphical abstract: The role of material structure and mechanical properties in cell–matrix interactions
From the themed collection: Emerging Investigators
Application

Multi-modal delivery of therapeutics using biomaterial scaffolds

Functionalisation of biomaterials with therapeutic moieties (proteins, drugs, genes) is a pre-requisite to tissue regeneration and restoration of function following injury or disease.

Graphical abstract: Multi-modal delivery of therapeutics using biomaterial scaffolds
Feature Article

Biomolecules-conjugated nanomaterials for targeted cancer therapy

Now and in the future, with the development of artificial biomolecules as well as nanomaterials, targeted drug delivery based on elegant biomolecule–nanomaterial conjugation approaches is being developed to achieve great versatility, additional functions, and further advances.

Graphical abstract: Biomolecules-conjugated nanomaterials for targeted cancer therapy
Feature Article

Engineering of biomimetic nanofibrous matrices for drug delivery and tissue engineering

Biomimetic nanofibrous matrices were fabricated by electrospinning, phase separation and molecular self-assembly for drug delivery and tissue engineering applications.

Graphical abstract: Engineering of biomimetic nanofibrous matrices for drug delivery and tissue engineering
Open Access Feature Article

Carbon nanomaterials as new tools for immunotherapeutic applications

The possibility to exploit carbon-based nanostructures such as carbon nanotubes and graphene as immunotherapeutic agents has interesting future prospects. In particular, their applications for anticancer treatment, imaging and vaccine development, together with their immunomodulator properties are highlighted.

Graphical abstract: Carbon nanomaterials as new tools for immunotherapeutic applications
Feature Article

Cellulose: from biocompatible to bioactive material

The immobilization of biomolecules onto cellulose paper turns this environmentally friendly material into a platform for diagnostic devices.

Graphical abstract: Cellulose: from biocompatible to bioactive material
Feature Article

Intrinsically conducting polymer nanowires for biosensing

The fabrication of conductive polymer nanowires and their sensing of nucleic acids, proteins and pathogens is reviewed in this feature article.

Graphical abstract: Intrinsically conducting polymer nanowires for biosensing
Feature Article

NIR luminescent nanomaterials for biomedical imaging

We review the recent progress in near-infrared nanomaterials from fabrication to application in biomedical imaging.

Graphical abstract: NIR luminescent nanomaterials for biomedical imaging
From the themed collection: Emerging Investigators
Feature Article

Engaging adaptive immunity with biomaterials

How does one avoid, control, or exploit adaptive immune responses using biomaterials? A review.

Graphical abstract: Engaging adaptive immunity with biomaterials
From the themed collection: Emerging Investigators
Feature Article

Micro- and nano-motors for biomedical applications

Micro- and nano-motors, a class of miniaturized manmade machines that are able to convert chemical or external energy into mechanical motion have been discussed and their application in the biomedical field was critically reviewed.

Graphical abstract: Micro- and nano-motors for biomedical applications
From the themed collection: Emerging Investigators
Feature Article

Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications

This review comprehensively summarizes and discusses stimuli-responsive and membrane-active peptides for biomedical applications including therapeutics delivery and antibiotics.

Graphical abstract: Synthetically designed peptide-based biomaterials with stimuli-responsive and membrane-active properties for biomedical applications
Feature Article

Chemical modification of inorganic nanostructures for targeted and controlled drug delivery in cancer treatment

This review summarized the most advanced designs of stimuli-responsive drug delivery systems based on inorganic nanoparticles.

Graphical abstract: Chemical modification of inorganic nanostructures for targeted and controlled drug delivery in cancer treatment
Communication

Metals & polymers in the mix: fine-tuning the mechanical properties & color of self-healing mussel-inspired hydrogels

Ways to orchestrate the mechanical properties and colors of mussel-inspired metal cross-linked hydrogels based on DOPA functionalized cationic polymers are demonstrated. This is achieved by systematically varying the hardness of the coordinating metal and/or the cationic polymer.

Graphical abstract: Metals & polymers in the mix: fine-tuning the mechanical properties & color of self-healing mussel-inspired hydrogels
Communication

Bio-inspired nanotadpoles with component-specific functionality

Plasmonic nanotadpoles showed the tail length dependence of their cellular uptake, enabling photothermal treatment of cancer cells with high efficacy.

Graphical abstract: Bio-inspired nanotadpoles with component-specific functionality
Communication

Rapid fabrication of silk films with controlled architectures via electrogelation

Through use of a closed-loop anode, we used electrogelation to fabricate silk films with controlled three-dimensional architectures.

Graphical abstract: Rapid fabrication of silk films with controlled architectures via electrogelation
Communication

A biomimetic hyperbranched poly(amino ester)-based nanocomposite as a tunable bone adhesive for sternal closure

A novel mussel-inspired adhesive can bond well to the surface of wet bone and be programmed to set in a suitable manner for sternal closure applications.

Graphical abstract: A biomimetic hyperbranched poly(amino ester)-based nanocomposite as a tunable bone adhesive for sternal closure
Communication

Metal-coordination: using one of nature's tricks to control soft material mechanics

Bio-inspired metal coordination allows tuning of aqueous polymer network mechanics via crosslink dynamics simply by the choice of coordinating metal.

Graphical abstract: Metal-coordination: using one of nature's tricks to control soft material mechanics
From the themed collection: Emerging Investigators
Communication

Thermo- and photo-enhanced microtubule formation from Ru(bpy)32+-conjugated tubulin

Ru(bpy)32+-conjugated tubulin is able to substantially enhance polymerization to form microtubules with increased rate at lower temperatures.

Graphical abstract: Thermo- and photo-enhanced microtubule formation from Ru(bpy)32+-conjugated tubulin
Paper

Reinforcement of biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with cellulose nanocrystal/silver nanohybrids as bifunctional nanofillers

Bifunctional cellulose nanocrystal/silver nanohybrids can simultaneously enhance the mechanical, thermal and antibacterial properties of PHBV nanocomposites for potential food packaging applications.

Graphical abstract: Reinforcement of biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) with cellulose nanocrystal/silver nanohybrids as bifunctional nanofillers
Paper

Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles

Protein polymer nanoparticles decorated with the mitogenic human tear protein, lacritin, heal a defect in the corneal epithelium faster than a soluble control peptide.

Graphical abstract: Lacritin-mediated regeneration of the corneal epithelia by protein polymer nanoparticles
From the themed collection: Nanoscale Biomaterials
Paper

Ultrasensitive QRS made by supramolecular assembly of functionalized cyclodextrins and graphene for the detection of lung cancer VOC biomarkers

A novel approach to control the selectivity of graphene-cyclodextrine sensors to cancer biomarkers by tailoring CD functionalization and assembly with graphene.

Graphical abstract: Ultrasensitive QRS made by supramolecular assembly of functionalized cyclodextrins and graphene for the detection of lung cancer VOC biomarkers
Paper

Presentation of HER2 epitopes using a filamentous plant virus-based vaccination platform

Farming of cancer vaccines: HER2-epitope display using the filamentous potato virus X platform yields HER2-specific sera in mice post-immunization.

Graphical abstract: Presentation of HER2 epitopes using a filamentous plant virus-based vaccination platform
Paper

Intrinsic peroxidase-like activity of mesoporous nickel oxide for selective cysteine sensing

Mesoporous NiO NFs show intrinsic peroxidase-like activity towards catalytic oxidation of TMB by H2O2 and, based on this process, cysteine can be detected with a LOD value ∼1.1 μM.

Graphical abstract: Intrinsic peroxidase-like activity of mesoporous nickel oxide for selective cysteine sensing
Paper

The preparation of an azo-substituted polyrotaxane end-capped with PNIPPAAm and its dual stimuli-responsive behavior for drug delivery applications

Micelles contracted and expanded alternately in response to UV/vis radiation, which offers a reversible on–off switch for controlling the drug release of the micelles.

Graphical abstract: The preparation of an azo-substituted polyrotaxane end-capped with PNIPPAAm and its dual stimuli-responsive behavior for drug delivery applications
Paper

Grafting zwitterionic polymer brushes via electrochemical surface-initiated atomic-transfer radical polymerization for anti-fouling applications

Grafting zwitterionic polymer brushes via electrochemically mediated-surface initiated atom transfer radical polymerization for anti-bacterial and anti-fouling applications.

Graphical abstract: Grafting zwitterionic polymer brushes via electrochemical surface-initiated atomic-transfer radical polymerization for anti-fouling applications
Paper

Facile non-hydrothermal synthesis of oligosaccharide coated sub-5 nm magnetic iron oxide nanoparticles with dual MRI contrast enhancement effects

A simple non-hydrothermal method was developed for synthesizing sugar coated 3 nm magnetic nanoparticles with dual T1T2 MRI contrast enhancement and fast clearance.

Graphical abstract: Facile non-hydrothermal synthesis of oligosaccharide coated sub-5 nm magnetic iron oxide nanoparticles with dual MRI contrast enhancement effects
Paper

Antibacterial activity studies of plasma polymerised cineole films

Costs associated with bacterial infections in medical devices exceed $US 30 billion each year in the United States alone due to device revisions and patient treatment.

Graphical abstract: Antibacterial activity studies of plasma polymerised cineole films
Paper

Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye

An aggregation-induced-emission active hemicyanine dye, TPE-Cy, shows high selectivity to homocysteine over glutathione and other amino acids.

Graphical abstract: Discrimination of homocysteine, cysteine and glutathione using an aggregation-induced-emission-active hemicyanine dye
Paper

UV light-triggered unpacking of DNA to enhance gene transfection of azobenzene-containing polycations

Photoresponsive azobenzene-containing polycationic nonviral vectors synthesized by ATRP demonstrated enhanced gene transfection due to the increased endocytosis and UV light-triggered intracellular gene unpacking.

Graphical abstract: UV light-triggered unpacking of DNA to enhance gene transfection of azobenzene-containing polycations
Paper

A fluorescent light-up probe with “AIE + ESIPT” characteristics for specific detection of lysosomal esterase

Fluorescent light-up probe with “AIE + ESIPT” characteristics for specific detection of lysosomal esterase.

Graphical abstract: A fluorescent light-up probe with “AIE + ESIPT” characteristics for specific detection of lysosomal esterase
Paper

Nanotopography as a trigger for the microscale, autogenous and passive lysis of erythrocytes

A mechano-responsive topology provides a highly active yet autogenous surface for erythrocyte lysis towards microfluidic haematology platforms.

Graphical abstract: Nanotopography as a trigger for the microscale, autogenous and passive lysis of erythrocytes
Open Access Paper

A modular approach to easily processable supramolecular bilayered scaffolds with tailorable properties

Electrospun bilayered scaffolds demonstrate how the specific properties of ureido-pyrimidinone (UPy) modified polymers and peptide building blocks are united in new supramolecular biomaterial assemblies via a mix-and-match approach.

Graphical abstract: A modular approach to easily processable supramolecular bilayered scaffolds with tailorable properties
From the themed collection: Emerging Investigators
Paper

Tailored biological retention and efficient clearance of pegylated ultra-small MnO nanoparticles as positive MRI contrast agents for molecular imaging

Ultra-small MnO nanoparticles pegylated with bis-phosphonate dendrons are efficient positive MRI contrast agents. They show prolonged vascular signal enhancement, followed by efficient excretion through the hepatobiliairy and urinary pathways. This considerably decreases the potential toxicity of MnO NPs.

Graphical abstract: Tailored biological retention and efficient clearance of pegylated ultra-small MnO nanoparticles as positive MRI contrast agents for molecular imaging
Paper

A TiO2-Au–polymer hybrid system for the photoelectrochemical immunoassay of SirT1

A photoelectrochemical assay of SirT1 in different cell lines based on a semiconductor–polymer hybrid system was reported.

Graphical abstract: A TiO2-Au–polymer hybrid system for the photoelectrochemical immunoassay of SirT1
Paper

Synthesis, structures and properties of self-assembling quaternary ammonium dansyl fluorescent tags for porous and non-porous surfaces

Surface grafted silane, phosphate and benzophenone dansyl molecules.

Graphical abstract: Synthesis, structures and properties of self-assembling quaternary ammonium dansyl fluorescent tags for porous and non-porous surfaces
Paper

Hydroxyapatite/gold/arginine: designing the structure to create antibacterial activity

Structural analogy with antibacterial peptides provides antibacterial property in newly developed HAp/Au/arginine nanocomposite. The material possesses: (i) high antibacterial activity, (ii) high cytocompatibility and (iii) good stability in physiological environment.

Graphical abstract: Hydroxyapatite/gold/arginine: designing the structure to create antibacterial activity
Paper

Synthesis of boronic acid-functionalized molecularly imprinted silica nanoparticles for glycoprotein recognition and enrichment

A novel method was developed for the synthesis of boronic acid-functionalized imprinted silica nanoparticles for recognition and enrichment of glycoproteins.

Graphical abstract: Synthesis of boronic acid-functionalized molecularly imprinted silica nanoparticles for glycoprotein recognition and enrichment
Paper

Noncytotoxic artificial bacterial flagella fabricated from biocompatible ORMOCOMP and iron coating

Noncytotoxic ABFs, made from biocompatible ORMOCOMP and iron, can precisely navigate under low-strength magnetic fields and have potential biomedical applications.

Graphical abstract: Noncytotoxic artificial bacterial flagella fabricated from biocompatible ORMOCOMP and iron coating
38 items

About this collection

This on-going web collection features all the articles published in Journal of Materials Chemistry B in 2014 marked as HOT, as recommended by referees. A selection of these is posted weekly on the Journal of Materials Chemistry Blog. Congratulations to all the authors whose articles are featured!

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