Issue 33, 2014

Facile non-hydrothermal synthesis of oligosaccharide coated sub-5 nm magnetic iron oxide nanoparticles with dual MRI contrast enhancement effects

Abstract

Ultrafine sub-5 nm magnetic iron oxide nanoparticles coated with oligosaccharides (SIO) with dual T1T2 weighted contrast enhancing effects and fast clearance have been developed as magnetic resonance imaging (MRI) contrast agents. Excellent water solubility, biocompatibility and high stability of such sub-5 nm SIO nanoparticles were achieved by using the “in situ polymerization” coating method, which enables glucose to form oligosaccharides directly on the surface of hydrophobic iron oxide nanocrystals. Reported ultrafine SIO nanoparticles exhibit a longitudinal relaxivity (r1) of 4.1 mM−1 s−1 and a r1/r2 ratio of 0.25 at 3 T (clinical field strength), rendering improved T1 or “brighter” contrast enhancement in T1-weighted MRI in addition to typical T2 or “darkening” contrast of conventional iron oxide nanoparticles. Such dual contrast effects can be demonstrated by liver imaging with T2 “darkening” contrast in the liver parenchyma but T1 “bright” contrast in the hepatic vasculature. More importantly, this new class of ultrafine sub-5 nm iron oxide nanoparticles showed much faster body clearance than those with larger sizes, promising better safety for clinical applications.

Graphical abstract: Facile non-hydrothermal synthesis of oligosaccharide coated sub-5 nm magnetic iron oxide nanoparticles with dual MRI contrast enhancement effects

Supplementary files

Article information

Article type
Paper
Submitted
19 May 2014
Accepted
20 Jun 2014
First published
24 Jun 2014

J. Mater. Chem. B, 2014,2, 5344-5351

Author version available

Facile non-hydrothermal synthesis of oligosaccharide coated sub-5 nm magnetic iron oxide nanoparticles with dual MRI contrast enhancement effects

J. Huang, L. Wang, X. Zhong, Y. Li, L. Yang and H. Mao, J. Mater. Chem. B, 2014, 2, 5344 DOI: 10.1039/C4TB00811A

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