Inverse method based on 3D nonlinear physically constrained minimisation in the framework of traction force microscopy
We present a new inverse and physically-consistent traction force microscopy method developed and implemented in the context of 3D nonlinear elasticity. We prove its enhanced accuracy applying it to real cases of cells cultured in a 3D hydrogel.
A model for 3D deformation and reconstruction of contractile microtissues
The combination of high-throughput three-dimensional (3D) culture systems and experimentally-validated computational models accelerate the study of cell-ECM interactions and tissue-scale deformation.
Tensile behavior of non-crosslinked networks of athermal fibers in the presence of entanglements and friction
A geometric definition of entanglements in athermal random networks is proposed and is linked to the network stiffness. Entanglements produce a self-equilibrated stress which increases the stiffness.
Spatiotemporal control of micromechanics and microstructure in acoustically-responsive scaffolds using acoustic droplet vaporization
Acoustic droplet vaporization (ADV) of phase shift emulsion (green) generates different bubble morphologies, and spatiotemporally tunes the micromechanics of fibrin gels (red).
Harnessing biomimetic cryptic bonds to form self-reinforcing gels
Cryptic sites, which lay hidden in folded biomolecules, become exposed by applied force and form new bonds that reinforce the biomaterial.
About this collection
This special issue, Guest Edited by Xiaoming Mao (University of Michigan) and Yair Shokef (Tel Aviv University) focuses on a wide variety of non-linear mechanical phenomena in biological contexts, and how they arise from the underlying fibrous structure of different biomaterials.
The issue presents contributions on theoretical, computational and experimental studies of natural, as well as synthetic, model systems, ranging from the molecular level, through the cellular level, to the tissue level. The results included in the collection will deal with the influence of non-linear mechanics on biological processes and also with mechanical features of biomaterials that are interesting in their own right.