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Themed collection Peptide Soft Materials

12 items
Review Article

Recent trends in the development of peptide and protein-based hydrogel therapeutics for the healing of CNS injury

This review article represents an overview of peptide and protein based hydrogel therapeutics as a gradually emerging excellent tissue engineering scaffold as well as drug delivery dais to treat severe CNS injury and its associated complications.

Graphical abstract: Recent trends in the development of peptide and protein-based hydrogel therapeutics for the healing of CNS injury
From the themed collection: Peptide Soft Materials
Review Article

Recent advances in the fabrication, functionalization, and bioapplications of peptide hydrogels

The structural and functional tailoring of peptide hydrogels promotes their bio-related applications.

Graphical abstract: Recent advances in the fabrication, functionalization, and bioapplications of peptide hydrogels
From the themed collection: Peptide Soft Materials
Communication

Affinity-based thermoresponsive fluorescence switching of proteins conjugated with a polymer-binding peptide

Affinity-based thermoresponsive fluorescence switching of proteins conjugated with a polymer-binding peptide is demonstrated. Specific affinity of the peptide and thermoresponsive structural transitions of the polymer are essential for the switching.

Graphical abstract: Affinity-based thermoresponsive fluorescence switching of proteins conjugated with a polymer-binding peptide
From the themed collection: Peptide Soft Materials
Accepted Manuscript - Communication

The Ratio of Hydrogelator and Precursor Controls Enzymatic Hydrogelation of a Branched Peptide

From the themed collection: Peptide Soft Materials
Paper

A spectroscopic and molecular dynamics study on the aggregation process of a long-acting lipidated therapeutic peptide: the case of semaglutide

The aggregation of semaglutide was followed from the early time steps to the late formation of mesoscopic dendrimeric structures.

Graphical abstract: A spectroscopic and molecular dynamics study on the aggregation process of a long-acting lipidated therapeutic peptide: the case of semaglutide
From the themed collection: Peptide Soft Materials
Paper

Acid-responsive fibrillation and urease-assisted defibrillation of phenylalanine: a transient supramolecular hydrogel

A mimic of living systems has been achieved by the acid-responsive assembly and urease-assisted disassembly of fibrils from benzyloxycarbonyl-L-phenylalanine, leading to a transient supramolecular hydrogel.

Graphical abstract: Acid-responsive fibrillation and urease-assisted defibrillation of phenylalanine: a transient supramolecular hydrogel
From the themed collection: Peptide Soft Materials
Paper

Bi-functional peptide-based 3D hydrogel-scaffolds

Over the last few years, hydrogels have been proposed for many biomedical applications, including drug delivery systems and scaffolds for tissue engineering.

Graphical abstract: Bi-functional peptide-based 3D hydrogel-scaffolds
From the themed collection: Peptide Soft Materials
Paper

The aging effect on the enhancement of thermal stability, mechanical stiffness and fluorescence properties of histidine-appended naphthalenediimide based two-component hydrogels

Two-component hydrogels show remarkable advancement in thermal and mechanical stabilities, and fluorescent intensity upon an unusual aging effect.

Graphical abstract: The aging effect on the enhancement of thermal stability, mechanical stiffness and fluorescence properties of histidine-appended naphthalenediimide based two-component hydrogels
From the themed collection: Peptide Soft Materials
Paper

Directed self-assembly of peptide–diketopyrrolopyrrole conjugates – a platform for bio-organic thin film preparation

Increased water solubility and long-range intermolecular ordering have been introduced into the fluorescent organic molecule thiophene-diketopyrrolopyrrole via its conjugation to the octapeptide HEFISTAH, derived from a protein–protein β-interface.

Graphical abstract: Directed self-assembly of peptide–diketopyrrolopyrrole conjugates – a platform for bio-organic thin film preparation
From the themed collection: Peptide Soft Materials
Paper

Self-assembly and intracellular delivery of DNA by a truncated fragment derived from the Trojan peptide Penetratin

A heptamer containing the longest noncationic amino acid sequence of Penetratin is shown to form peptiplexes with DNA. The structure is characterized from molecular to nanoscopic scale and peptiplexes are shown to assist intracell delivery of DNA.

Graphical abstract: Self-assembly and intracellular delivery of DNA by a truncated fragment derived from the Trojan peptide Penetratin
From the themed collection: Peptide Soft Materials
Paper

Polymorphism of asymmetric catalysts based on amphiphilic lipopeptides in solution

The self-assembly of model [P]RWG lipopeptides (P: L-proline, R: L-arginine, W: L-tryptophan, G: L-glycine), containing one or two aliphatic octadecyl (C18) chains in water and cyclohexanone/water solutions was examined. The enantiomeric selectivity was found to be related to the assembly of catalyst molecules.

Graphical abstract: Polymorphism of asymmetric catalysts based on amphiphilic lipopeptides in solution
From the themed collection: Peptide Soft Materials
Paper

Chemical stimulus-responsive supramolecular hydrogel formation and shrinkage of a hydrazone-containing short peptide derivative

Herein, we describe a short peptide derivative containing a hydrazone bond showing transient hydrogel formation triggered by hydrazone–oxime exchange reaction.

Graphical abstract: Chemical stimulus-responsive supramolecular hydrogel formation and shrinkage of a hydrazone-containing short peptide derivative
From the themed collection: Peptide Soft Materials
12 items

About this collection

This special issue, Guest Edited by Arindam Banerjee, Indian Association for the Cultivation of Science, and Ian Hamley, University of Reading, focuses on peptide soft materials in their broadest sense and covers the development of peptide soft materials such as peptide-based hydro- and organo-gels, nanostructured peptide biomaterials, emulsions and capsules.
 
The issue presents examples of the diverse applications of soft matter peptide systems as responsive materials for diagnostics, therapeutics and remediation with particular relevance to new biomedical applications. It also discusses state-of-the-art examples of novel peptide hybrid systems, in which peptides are combined (covalently or in mixture formulations) with polymers, lipids, polysaccharides and nucleic acids.

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