Glycosylation, an effective synthetic strategy to improve the bioavailability of therapeutic peptides
Glycosylation of peptides is a promising strategy for modulating the physicochemical properties of peptide drugs and for improving their absorption through biological membranes.
Construction of homogeneous antibody–drug conjugates using site-selective protein chemistry
The use of site-selective chemical drug-conjugation strategies enables the construction of antibody–drug conjugates (ADCs) with superior therapeutic efficacy.”
Peptide-based synthetic vaccines
This review summarise the current stand and future perspective on synthetic peptide-based vaccines.
A unique approach toward near-infrared fluorescent probes for bioimaging with remarkably enhanced contrast
A universal sensing platform with significantly enhanced image contrast and apparent brightness in biological imaging applications.
Structurally plastic peptide capsules for synthetic antimicrobial viruses
A conceptual design for artificial antimicrobial viruses is described.
Single near-infrared fluorescent probe with high- and low-sensitivity sites for sensing different concentration ranges of biological thiols with distinct modes of fluorescence signals
We describe a unique approach for the development of an interesting type of the fluorescent probes, which can show different modes of fluorescence signals to distinct concentration ranges of a target of interest.
A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells
A probe for the in situ monitoring of singlet oxygen generation during targeted theranostic photodynamic therapy is developed based on a photosensitizer with aggregation-induced emission (AIE) characteristics and conjugated to a fluorogenic rhodol dye via a singlet oxygen cleavable linker.
An ultrasensitive near-infrared ratiometric fluorescent probe for imaging mitochondrial polarity in live cells and in vivo
We describe a new mitochondria-targeting fluorescent probe MCY-BF2 that is singularly sensitive and specifically responsive to mitochondrial polarity.
A novel quenched fluorescent activity-based probe reveals caspase-3 activity in the endoplasmic reticulum during apoptosis
A selective quenched activity-based probe detects caspase-3 activity in the endoplasmic reticulum of cancerous cells during apoptosis.
A highly selective near-infrared fluorescent probe for imaging H2Se in living cells and in vivo
The first near-infrared fluorescent probe to detect H2Se with high sensitivity was explored in living cells and in mice.
LNA-enhanced DNA FIT-probes for multicolour RNA imaging
A surrogate nucleobase based on 4,4'-cyanine provided up to 195-fold enhancement of red fluorescence upon complementary RNA binding. A mixture of FIT probes allowed the localization of oskar mRNA and other polyadenylated mRNA molecules in developing oocytes from Drosphila melanogaster by wash-free FISH and STED.
Profiling the reactivity of cyclic C-nucleophiles towards electrophilic sulfur in cysteine sulfenic acid
Oxidation of a protein cysteine thiol to sulfenic acid, termed S-sulfenylation, is a reversible post-translational modification that plays a crucial role in regulating protein function and is correlated with disease states.
An optoelectronic nose for identification of explosives
A portable optoelectronic nose for the identification of explosives uses a highly cross-reactive colorimetric sensor array and a handheld scanner.
Accurate calculation of the absolute free energy of binding for drug molecules
Free energy calculations based on molecular dynamics and thermodynamic cycles accurately reproduce experimental affinities of diverse bromodomain inhibitors.
A minimalist fluorescent probe for differentiating Cys, Hcy and GSH in live cells
A simple and versatile probe was discovered for discriminating between different thiol species with the use of CTAB (cetyl trimethylammonium bromide).
About this collection
We are delighted to present a collection showcasing the 50 most downloaded Chemical Science articles of 2016. This is only available for a limited time and provides an easy way to quickly access the most important papers published in Chemical Science in the past year. These articles highlight exciting and impactful research across a broad range of subject areas, analytical chemistry, chemical biology, catalysis, energy, inorganic chemistry, materials science, nanoscience, organic chemistry and physical chemistry. We hope you enjoy reading this collection!