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Issue 3, 2016

A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

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Abstract

The real-time monitoring of reactive oxygen species (ROS, particularly singlet oxygen) generation during photodynamic therapy is a great challenge due to the extremely short half-life and small radius of action. To tackle this issue, we herein report a bioprobe composed of a red emissive photosensitizer (PS) with aggregation-induced emission (AIE) characteristics and a fluorogenic green emissive rhodol dye conjugated via a singlet oxygen cleavable aminoacrylate (AA) linker. The probe emits red fluorescence in water, and the red emissive PS can be used for probe self-tracking. Upon image-guided light irradiation, the generated singlet oxygen cleaves the AA linker to yield green fluorescence turn-on of rhodol, which offers real-time and in situ monitoring of singlet oxygen generation during photodynamic ablation of cancer cells, providing a strategy for the early evaluation of the therapeutic effect.

Graphical abstract: A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

Supplementary files

Article information


Submitted
22 Sep 2015
Accepted
23 Nov 2015
First published
23 Nov 2015

This article is Open Access
All publication charges for this article have been paid for by the Royal Society of Chemistry

Chem. Sci., 2016,7, 1862-1866
Article type
Edge Article

A self-reporting AIE probe with a built-in singlet oxygen sensor for targeted photodynamic ablation of cancer cells

Y. Yuan, C. Zhang, S. Xu and B. Liu, Chem. Sci., 2016, 7, 1862 DOI: 10.1039/C5SC03583J

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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