Themed collection Contributions from the chemical industry

This review highlights the efforts made to date to promote greener peptide synthesis, from an industrial perspective.

Cotranslational protein folding is a vectorial process, and for membrane proteins, N-terminal helical segments are the first that become available for membrane insertion. Here fragments corresponding to these segments are investigated by NMR.

Aminoacyl PGA: a biodegradable polyester modified with amino acids to provide a range of physicochemical characteristics for interaction with drugs.

PEG-conjugated collagen-like peptides promote corneal regeneration in a pig cornea.

A mild convenient method for the aqueous reduction of a range of organic functionalities and the reductive amination of nitriles using a heterogeneous copper catalyst formed in situ.

The regioselective iridium-catalysed C3-borylation of 1H-indazoles has been achieved. Subsequent Suzuki–Miyaura coupling of the boronate esters with aryl chlorides, bromides and iodides affords 3-aryl-1H-indazoles in good yields.

The simple and inexpensive N,N-dimethylcyclohexane-1,2-diamine/CuI catalytic system provides a versatile, easy and efficient access to an array of N-(2-pyridin-2-yl)-amides from 2-chloro-pyridine derivatives.

An iridium-catalysed hydrogen transfer reaction was successfully applied in the synthesis of 2-substituted quinazolines in moderate yields starting from aldehydes or alcohols with 2-aminobenzylamines.

A streamlined automated synthesis for S. pneumoniae type 14 and Group B Streptococcus type III capsular oligosaccharides with only one set of three building blocks is presented. Competitive ELISA provides some insight into minimal epitope.

The use of a high rigidity separator and application of an appropriate amount of pressure are effective approaches to control lithium metal growth and improve its cycle performance.

Detail comparison of two different electrokinetic phenomena EOF and SP method for the SZP determination with taking into account various materials with different surface and bulk properties.

A bipyridyl reagent containing a strained alkyne 7, reacts with benzyl azide to give a significantly more flexible product 10 and an increase in fluorescence is observed. Upon addition of Zn(II), the fluorescence is enhanced further.

Vertically oriented boron nitride flakes on a polymer surface exhibit bactericidal activity.

Insight is given on the type of ion-pairs that could be formed in EC/DMC by Li-salts LiTDI, LiFSI and LiPF₆.

The biocatalytic asymmetric Michael addition of L-arginine to fumarate using argininosuccinate lyase (ASL) has enabled the synthesis of the key metabolite L-argininosuccinic acid lithium salt 1 for the first time, with excellent yield and purity.

We report the gas-phase hydrogenolysis of glycerol to 1,3-propanediol over Pt/WO₃/Al₂O₃ in a fluidized bed operating above 240 °C and at ambient pressure.

The use of alkyl acetates as green organic solvents for the Cu-catalysed arylation of phenols and amides is reported.

The effect of protein concentration on solution viscosity in a commercially available biopharmaceutical formulation of recombinant albumin (rAlbumin) was studied.

Pure formic acid was produced via CO₂ hydrogenation over a heterogeneous PdNi alloy catalyst on carbon nanotube-graphene support in water solvent without a base additive.

Potential anticancer derivatives of the β-carboline alkaloid harmine exhibit substituent dependent serum protein binding.

We present a comprehensive approach to characterize the one-pot synthesis, macropore space morphology, and chromatographic performance of phenyl-modified macro–mesoporous silica monoliths.

Highly condensed oxepins have been prepared in good yields from their corresponding diols by etherification using p-toluenesulfonic acid.