Themed collection Reviews & Highlights in Organic Chemistry Frontiers for 2014
The 2-phosphaethynolate anion: convenient synthesis and the reactivity
New members in the family of organophosphorus compounds: convenient synthesis and reactivity of the 2-phosphaethynolate anion are highlighted.
Pyridine synthesis by [4 + 2] cycloadditions of 1-azadienes: hetero-Diels Alder and transition metal-catalysed approaches
Cycloaddition reactions are powerful tools in synthetic chemistry.
Bottom-up chemical synthesis of three-dimensional conjugated carbon nanostructures: from carbon nanocages to carbon nanotubes
In this highlight, recent advances in the rational bottom-up chemical synthesis of three-dimensional (3-D) conjugated carbon nanostructures are presented.
Chopping unfunctionalized carbon–carbon bonds: a new paradigm for the synthesis of organonitriles
Chopping of carbon–carbon bonds was very recently shown to be an efficient new strategy for the synthesis of organonitriles, as developed in this Highlight.
Transition-metal-catalyzed direct β-functionalization of simple carbonyl compounds
Chemical transformations via catalytic C–H bond activation have been established as one of the most powerful tools in organic synthetic chemistry. Transition-metal-catalyzed direct functionalization of β-C(sp3)–H bonds of carbonyl compounds has been developed in recent years. This highlight will focus on recent advances in this active area and their mechanisms are also discussed.
Modern multicomponent reactions for better drug syntheses
Multicomponent reaction (MCR) technology is now widely recognized for its impact on drug discovery projects and is strongly endorsed by industry as well as academia.
Catalytic fluorination of unactivated C(sp3)–H bonds
This Highlight discusses the most recent advances in catalytic fluorination of benzylic, allylic, and aliphatic unactivated C(sp3)–H bonds.
Enantioselective heterogeneous Brønsted acid catalysis
This highlight describes the state-of-the-art applications of appropriately designed heterogeneous chiral Brønsted acid catalysts and their applications in organic synthesis.
The redox-A3 reaction
This highlight details the recent emergence of a new type of A3 reaction that features a redox-neutral C–H functionalization step.
Recent advances in C–H fluorination
Highlighted in this article are recent advances in C(sp2)–H and C(sp3)–H fluorination reactions.
Copper-mediated/-catalyzed fluorination reactions: new routes to aryl fluorides
Recent advances in direct fluorination of aromatic compounds by copper catalysts have been highlighted.
Recent studies on the chemical constituents of Trigonostemon plants
The plants of the Trigonostemon genus (Euphorbiaceae family) comprising about 50 species are mainly distributed in tropical and subtropical Asia.
Conquering three-carbon axial chirality of allenes
Axially chiral allenes are an important class of molecules widely existing in nature and also valuable chiral building blocks for organic synthesis. With more and more new protocols for racemic allenes and new chiral ligands being developed, a wide variety of novel and challenging transformations have been recently unveiled for the synthesis of this type of highly versatile compounds. In this review, we present a critical account of the enantioselective synthesis of axially chiral allenes.
Organometallic intermediate-based organic synthesis: organo-di-lithio reagents and beyond
Metal-mediated organic reactions have become one of the great frontiers of organic synthesis.
Recent advances in directed C–H functionalizations using monodentate nitrogen-based directing groups
This review focuses specially on the use of monodentate nitrogen-based directing group for C–H functionalization published during the past 2 years (2012–2013).
Synthesis and modification of octafluoro[2.2]paracyclophane (parylene AF4)
Parylenes are a class of organic compounds which have gained significant attention due to their application as coatings in areas such as medical devices and electronics.
Direct activation of relatively unstrained carbon–carbon bonds in homogeneous systems
This review highlights the frontier of carbon–carbon bond activation and discusses state-of-the-art methods for activating relatively unstrained bonds in homogeneous systems.
Sonogashira coupling in natural product synthesis
This review will focus on selected applications of Sonogashira coupling and subsequent transformations as key steps in the total synthesis of natural products.
Synthesis of organic halides via palladium(0) catalysis
This review summarizes the recent advances on the Pd(0)-catalyzed synthesis of organic halides, which involves the carbon halide reductive elimination as a key step in the catalytic cycle.
Catalytic asymmetric allylation of carbonyl compounds and imines with allylic boronates
Enantioselective allylation is a highly used organic reaction to prepare chiral homoallylic alcohols and amines, which serve as important building blocks in the synthesis of a variety of natural products and pharmaceuticals.
Iron-catalyzed/mediated oxidative transformation of C–H bonds
Iron-catalyzed/mediated C–H bond oxidation has been demonstrated as one of practical and straightforward tools in synthetic chemistry.
Recent applications of Cp2TiCl in natural product synthesis
Titanocene(III)-based approaches have been demonstrated to be useful in the straightforward syntheses of many natural products from readily available starting materials.
About this collection
Review articles and Highlights published by Organic Chemistry Frontiers in 2014 are collated as below for the benefit of readers.