Phototherapy of cutaneous T-cell lymphomas
Cutaneous T-cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas arising in the skin. Phototherapy with ultraviolet radiation, introduced in 1976, is still a mainstay of treatment. Depending on CTCL variant and stage psoralen and ultraviolet A, narrow-band ultraviolet B, or photopheresis are used and can provide effective palliation for many patients.
Drug and chemical induced photosensitivity from a clinical perspective
Drug photosensitivity is a relatively common occurrence and a range of mechanisms may be involved.
Melanoma – role of the environment and genetics
This paper illustrates the independent and interactive role of genetic and environmental factors in the etiology of melanoma.
Solar UV damage to cellular DNA: from mechanisms to biological effects
Solar ultraviolet (UV) radiation generates bulky photodimers at di-pyrimidine sites that pose stress to cells and organisms by hindering DNA replication and transcription.
Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation
Based on the polη-dependent TLS across deaminated CPDs, the wavelength dependence of UVR mutations can be explained by different photochemistries of CPD formation, the singlet/triplet and collective excitations that cause UV-signature and UVA-signature mutations, respectively.
Formation of UV-induced DNA damage contributing to skin cancer development
UV-induced DNA damage plays a key role in the initiation phase of skin cancer. Their yield and chemical structure strongly depend on the wavelength.
Ultraviolet radiation-induced immunosuppression and its relevance for skin carcinogenesis
Major steps in the pathway leading to the increased risk of skin cancer by the immunosuppression induced by UVR exposure.
Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis
The development of photodynamic therapy and photodiagnosis with 5-aminolevulinic acid presents a number of challenges that can be addressed by applying chemical insight and a range of novel prodrug strategies.
Wastewater chemical contaminants: remediation by advanced oxidation processes
A review on novel approaches for wastewater remediation based on advanced oxidation processes (AOPs), including the photodynamic approach mediated by tetrapyrrolic derivatives.
Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer
A review describing the state-of-the-art of the functionalisation of gold nanoparticles with photosensitisers and targeting ligands for photodynamic cancer therapy.
Some activities of PorphyChem illustrated by the applications of porphyrinoids in PDT, PIT and PDI
Photodynamic therapy is an innovative approach to treat diverse cancers and diseases that involves the use of photosensitizing agents along with light of an appropriate wavelength to generate cytotoxic reactive oxygen species.
Combination of PDT photosensitizers with NO photodononors
The appropriate assembly of PDT photosensitizers and NO photodonors may open up intriguing avenues towards new and still underexplored multimodal therapies not based on “conventional” drugs but entirely controlled by light stimuli.
Fullerenes as photosensitizers in photodynamic therapy: pros and cons
Fullerenes can act as photosensitizers for photodynamic therapy. Advantages include chemical and photochemical versatility, nanotechnology potential, resistance to photobleaching. Disadvantages include short wavelength absorption, pronounced aggregate and high molecular weight.
Mesoporous silica nanoparticles in recent photodynamic therapy applications
In this review, the use of mesoporous silica nanoparticles for photodynamic therapy (PDT) applications is described for the year 2017.
Using X-rays in photodynamic therapy: an overview
Photodynamic therapy is a therapeutic option to treat cancer and other diseases.
A glycoporphyrin story: from chemistry to PDT treatment of cancer mouse models
Glycoporphyrin: from bench to preclinical studies on PDX xenografted on mice.
Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review
BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region.
The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy
To afford effective photosensitizers and delivery systems for photodynamic therapy their design phase must consider all aspects of singlet oxygen. This perspective highlights that progression of this field is dependent on the control and modulation of its star, singlet oxygen.
Environmental effects of ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2017
The present 2017 Update Report assesses some of the highlights about the interactive nature of the direct and indirect effects of UV radiation, atmospheric processes, and climate change.
About this collection
This web collection contains Perspective articles that Photochemical & Photobiological Sciences has published in 2018.