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Themed collection 2018 Perspective article collection

19 items
Perspective

Phototherapy of cutaneous T-cell lymphomas

Cutaneous T-cell lymphomas (CTCL) are a heterogenous group of non-Hodgkin lymphomas arising in the skin. Phototherapy with ultraviolet radiation, introduced in 1976, is still a mainstay of treatment. Depending on CTCL variant and stage psoralen and ultraviolet A, narrow-band ultraviolet B, or photopheresis are used and can provide effective palliation for many patients.

Graphical abstract: Phototherapy of cutaneous T-cell lymphomas
Perspective

Drug and chemical induced photosensitivity from a clinical perspective

Drug photosensitivity is a relatively common occurrence and a range of mechanisms may be involved.

Graphical abstract: Drug and chemical induced photosensitivity from a clinical perspective
Perspective

Melanoma – role of the environment and genetics

This paper illustrates the independent and interactive role of genetic and environmental factors in the etiology of melanoma.

Graphical abstract: Melanoma – role of the environment and genetics
Perspective

Solar UV damage to cellular DNA: from mechanisms to biological effects

Solar ultraviolet (UV) radiation generates bulky photodimers at di-pyrimidine sites that pose stress to cells and organisms by hindering DNA replication and transcription.

Graphical abstract: Solar UV damage to cellular DNA: from mechanisms to biological effects
Perspective

Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation

Based on the polη-dependent TLS across deaminated CPDs, the wavelength dependence of UVR mutations can be explained by different photochemistries of CPD formation, the singlet/triplet and collective excitations that cause UV-signature and UVA-signature mutations, respectively.

Graphical abstract: Mechanistic considerations on the wavelength-dependent variations of UVR genotoxicity and mutagenesis in skin: the discrimination of UVA-signature from UV-signature mutation
Perspective

Formation of UV-induced DNA damage contributing to skin cancer development

UV-induced DNA damage plays a key role in the initiation phase of skin cancer. Their yield and chemical structure strongly depend on the wavelength.

Graphical abstract: Formation of UV-induced DNA damage contributing to skin cancer development
Perspective

Ultraviolet radiation-induced immunosuppression and its relevance for skin carcinogenesis

Major steps in the pathway leading to the increased risk of skin cancer by the immunosuppression induced by UVR exposure.

Graphical abstract: Ultraviolet radiation-induced immunosuppression and its relevance for skin carcinogenesis
Open Access Perspective

Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

The development of photodynamic therapy and photodiagnosis with 5-aminolevulinic acid presents a number of challenges that can be addressed by applying chemical insight and a range of novel prodrug strategies.

Graphical abstract: Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis
From the themed collection: 2018 Perspective article collection
Perspective

Wastewater chemical contaminants: remediation by advanced oxidation processes

A review on novel approaches for wastewater remediation based on advanced oxidation processes (AOPs), including the photodynamic approach mediated by tetrapyrrolic derivatives.

Graphical abstract: Wastewater chemical contaminants: remediation by advanced oxidation processes
From the themed collection: 2018 Perspective article collection
Perspective

Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer

A review describing the state-of-the-art of the functionalisation of gold nanoparticles with photosensitisers and targeting ligands for photodynamic cancer therapy.

Graphical abstract: Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer
From the themed collection: 2018 Perspective article collection
Perspective

Some activities of PorphyChem illustrated by the applications of porphyrinoids in PDT, PIT and PDI

Photodynamic therapy is an innovative approach to treat diverse cancers and diseases that involves the use of photosensitizing agents along with light of an appropriate wavelength to generate cytotoxic reactive oxygen species.

Graphical abstract: Some activities of PorphyChem illustrated by the applications of porphyrinoids in PDT, PIT and PDI
From the themed collection: 2018 Perspective article collection
Perspective

Combination of PDT photosensitizers with NO photodononors

The appropriate assembly of PDT photosensitizers and NO photodonors may open up intriguing avenues towards new and still underexplored multimodal therapies not based on “conventional” drugs but entirely controlled by light stimuli.

Graphical abstract: Combination of PDT photosensitizers with NO photodononors
From the themed collection: 2018 Perspective article collection
Perspective

Fullerenes as photosensitizers in photodynamic therapy: pros and cons

Fullerenes can act as photosensitizers for photodynamic therapy. Advantages include chemical and photochemical versatility, nanotechnology potential, resistance to photobleaching. Disadvantages include short wavelength absorption, pronounced aggregate and high molecular weight.

Graphical abstract: Fullerenes as photosensitizers in photodynamic therapy: pros and cons
From the themed collection: 2018 Perspective article collection
Perspective

Mesoporous silica nanoparticles in recent photodynamic therapy applications

In this review, the use of mesoporous silica nanoparticles for photodynamic therapy (PDT) applications is described for the year 2017.

Graphical abstract: Mesoporous silica nanoparticles in recent photodynamic therapy applications
From the themed collection: 2018 Perspective article collection
Perspective

Using X-rays in photodynamic therapy: an overview

Photodynamic therapy is a therapeutic option to treat cancer and other diseases.

Graphical abstract: Using X-rays in photodynamic therapy: an overview
From the themed collection: 2018 Perspective article collection
Perspective

A glycoporphyrin story: from chemistry to PDT treatment of cancer mouse models

Glycoporphyrin: from bench to preclinical studies on PDX xenografted on mice.

Graphical abstract: A glycoporphyrin story: from chemistry to PDT treatment of cancer mouse models
From the themed collection: 2018 Perspective article collection
Perspective

Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review

BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region.

Graphical abstract: Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review
From the themed collection: 2018 Perspective article collection
Perspective

The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

To afford effective photosensitizers and delivery systems for photodynamic therapy their design phase must consider all aspects of singlet oxygen. This perspective highlights that progression of this field is dependent on the control and modulation of its star, singlet oxygen.

Graphical abstract: The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy
From the themed collection: 2018 Perspective article collection
Perspective

Environmental effects of ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2017

The present 2017 Update Report assesses some of the highlights about the interactive nature of the direct and indirect effects of UV radiation, atmospheric processes, and climate change.

Graphical abstract: Environmental effects of ozone depletion, UV radiation and interactions with climate change: UNEP Environmental Effects Assessment Panel, update 2017
From the themed collection: 2018 Perspective article collection
19 items

About this collection

This web collection contains Perspective articles that Photochemical & Photobiological Sciences has published in 2018.

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