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Drug and chemical induced photosensitivity from a clinical perspective

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Abstract

Drug photosensitivity is a relatively common occurrence and a range of mechanisms may be involved. Some of these mechanisms will be discussed, including the most common, that of drug phototoxicity. Different types of photosensitivity are addressed with respect to clinical presentation, mechanisms and additionally the contribution to our understanding through clinically directed investigations and regulatory requirements. Repeated controlled therapeutic use of drug phototoxicity, with psoralen-UVA (PUVA) photochemotherapy and photodynamic therapy (PDT) will also be discussed. Finally, the potential for drug-induced photocarcinogenesis will also be covered.

Graphical abstract: Drug and chemical induced photosensitivity from a clinical perspective

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Publication details

The article was received on 12 Jan 2018, accepted on 09 Sep 2018 and first published on 10 Sep 2018


Article type: Perspective
DOI: 10.1039/C8PP00011E
Citation: Photochem. Photobiol. Sci., 2018, Advance Article
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    Drug and chemical induced photosensitivity from a clinical perspective

    S. Ibbotson, Photochem. Photobiol. Sci., 2018, Advance Article , DOI: 10.1039/C8PP00011E

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