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Issue 11, 2018
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Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

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Abstract

The administration of 5-aminolevulinic acid (ALA) to generate enhanced intracellular levels of endogenous porphyrins is currently one of the most important approaches for photodynamic therapy (PDT) and photodiagnosis (PDD). Despite the great promise of ALA-based PDT, the physicochemical behaviour and chemical reactivity of ALA are problematic, and a variety of chemical approaches have been brought to bear to improve cellular delivery, enhance porphyrin production, and generate ALA prodrugs that have appropriate stability for convenient clinical use, as well as selectivity for cancerous tissues. While there has been considerable success, there are still a number of challenges to be addressed and opportunities to be exploited through application of chemical insight in this area.

Graphical abstract: Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

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Publication details

The article was received on 06 Aug 2018, accepted on 05 Oct 2018 and first published on 08 Oct 2018


Article type: Perspective
DOI: 10.1039/C8PP00362A
Citation: Photochem. Photobiol. Sci., 2018,17, 1553-1572
  • Open access: Creative Commons BY-NC license
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    Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

    K. M. Tewari and I. M. Eggleston, Photochem. Photobiol. Sci., 2018, 17, 1553
    DOI: 10.1039/C8PP00362A

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