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Themed collection Nano- and Molecular Engineering of Photosensitisers

19 items
Editorial

Introduction to the themed issue ‘Nano- and Molecular Engineering of Photosensitisers’

Welcome to this Photochemical & Photobiological Sciences themed issue entitled: ‘Nano- and Molecular Engineering of Photosensitisers’.

Graphical abstract: Introduction to the themed issue ‘Nano- and Molecular Engineering of Photosensitisers’
Open Access Perspective

Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis

The development of photodynamic therapy and photodiagnosis with 5-aminolevulinic acid presents a number of challenges that can be addressed by applying chemical insight and a range of novel prodrug strategies.

Graphical abstract: Chemical approaches for the enhancement of 5-aminolevulinic acid-based photodynamic therapy and photodiagnosis
From the themed collection: 2018 Perspective article collection
Perspective

Wastewater chemical contaminants: remediation by advanced oxidation processes

A review on novel approaches for wastewater remediation based on advanced oxidation processes (AOPs), including the photodynamic approach mediated by tetrapyrrolic derivatives.

Graphical abstract: Wastewater chemical contaminants: remediation by advanced oxidation processes
From the themed collection: 2018 Perspective article collection
Perspective

Fullerenes as photosensitizers in photodynamic therapy: pros and cons

Fullerenes can act as photosensitizers for photodynamic therapy. Advantages include chemical and photochemical versatility, nanotechnology potential, resistance to photobleaching. Disadvantages include short wavelength absorption, pronounced aggregate and high molecular weight.

Graphical abstract: Fullerenes as photosensitizers in photodynamic therapy: pros and cons
From the themed collection: 2018 Perspective article collection
Perspective

A glycoporphyrin story: from chemistry to PDT treatment of cancer mouse models

Glycoporphyrin: from bench to preclinical studies on PDX xenografted on mice.

Graphical abstract: A glycoporphyrin story: from chemistry to PDT treatment of cancer mouse models
From the themed collection: 2018 Perspective article collection
Perspective

Some activities of PorphyChem illustrated by the applications of porphyrinoids in PDT, PIT and PDI

Photodynamic therapy is an innovative approach to treat diverse cancers and diseases that involves the use of photosensitizing agents along with light of an appropriate wavelength to generate cytotoxic reactive oxygen species.

Graphical abstract: Some activities of PorphyChem illustrated by the applications of porphyrinoids in PDT, PIT and PDI
From the themed collection: 2018 Perspective article collection
Paper

Cyclopeptidic photosensitizer prodrugs as proteolytically triggered drug delivery systems of pheophorbide A: part I – self-quenched prodrugs

RAFTs bearing multiple copies of pheophorbide A allow perfectly defined photosensitizer prodrugs.

Graphical abstract: Cyclopeptidic photosensitizer prodrugs as proteolytically triggered drug delivery systems of pheophorbide A: part I – self-quenched prodrugs
Paper

Cyclopeptidic photosensitizer prodrugs as proteolytically triggered drug delivery systems of pheophorbide A: part II – co-loading of pheophorbide A and black hole quencher

Co-loading of pheophorbide A and black hole quencher moieties onto cyclopeptidic templates led to photosensitizer prodrugs with ultra-high initial quenching.

Graphical abstract: Cyclopeptidic photosensitizer prodrugs as proteolytically triggered drug delivery systems of pheophorbide A: part II – co-loading of pheophorbide A and black hole quencher
Perspective

Combination of PDT photosensitizers with NO photodononors

The appropriate assembly of PDT photosensitizers and NO photodonors may open up intriguing avenues towards new and still underexplored multimodal therapies not based on “conventional” drugs but entirely controlled by light stimuli.

Graphical abstract: Combination of PDT photosensitizers with NO photodononors
From the themed collection: 2018 Perspective article collection
Paper

Effect of thiophene substitution on the intersystem crossing of arene photosensitizers

Thiophene substitution gives energy level-matched S1/T2 states and the ISC is enhanced, which was not observed with phenyl substitution.

Graphical abstract: Effect of thiophene substitution on the intersystem crossing of arene photosensitizers
Perspective

Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer

A review describing the state-of-the-art of the functionalisation of gold nanoparticles with photosensitisers and targeting ligands for photodynamic cancer therapy.

Graphical abstract: Photosensitiser-gold nanoparticle conjugates for photodynamic therapy of cancer
From the themed collection: 2018 Perspective article collection
Perspective

Mesoporous silica nanoparticles in recent photodynamic therapy applications

In this review, the use of mesoporous silica nanoparticles for photodynamic therapy (PDT) applications is described for the year 2017.

Graphical abstract: Mesoporous silica nanoparticles in recent photodynamic therapy applications
From the themed collection: 2018 Perspective article collection
Paper

Investigation of the factors affecting the photothermal therapy potential of small iron oxide nanoparticles over the 730–840 nm spectral region

Photothermal activity of SPIONs is not dependent on the excitation wavelength, attenuation or laser intensity but to the power.

Graphical abstract: Investigation of the factors affecting the photothermal therapy potential of small iron oxide nanoparticles over the 730–840 nm spectral region
Perspective

Using X-rays in photodynamic therapy: an overview

Photodynamic therapy is a therapeutic option to treat cancer and other diseases.

Graphical abstract: Using X-rays in photodynamic therapy: an overview
From the themed collection: 2018 Perspective article collection
Paper

Synthetic, small-molecule photoantimicrobials – a realistic approach

Small molecule cationic photosensitizers based on standard chromophores offer considerable potential in photoantimicrobial development via chromophore elaboration or peripheral functionalisation.

Graphical abstract: Synthetic, small-molecule photoantimicrobials – a realistic approach
Paper

Photodynamic properties of aza-analogues of phthalocyanines

Spectral and photophysical properties and in vitro photodynamic activity of aza-analogues of phthalocyanines are summarized.

Graphical abstract: Photodynamic properties of aza-analogues of phthalocyanines
Perspective

The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy

To afford effective photosensitizers and delivery systems for photodynamic therapy their design phase must consider all aspects of singlet oxygen. This perspective highlights that progression of this field is dependent on the control and modulation of its star, singlet oxygen.

Graphical abstract: The good, the bad, and the ugly – controlling singlet oxygen through design of photosensitizers and delivery systems for photodynamic therapy
From the themed collection: 2018 Perspective article collection
Perspective

Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review

BODIPYs are photosensitizers activatable by light to generate highly reactive singlet oxygen (1O2) from molecular oxygen, leading to tissue damage in the photoirradiated region.

Graphical abstract: Recent strategies to improve boron dipyrromethene (BODIPY) for photodynamic cancer therapy: an updated review
From the themed collection: 2018 Perspective article collection
Paper

Antibacterial activity of a photosensitive hybrid cellulose fabric

A new photosensitive hybrid cellulose material, synthesized by polymerization of methacrylic acid (MAA) and PpIX, showed photoantibacterial activity against Staphylococcus aureus.

Graphical abstract: Antibacterial activity of a photosensitive hybrid cellulose fabric
19 items

About this collection

Like many English words, photosensitiser arises from Greek roots and literally means something sensitive to light, clearly a very broad definition. In this themed issue of Photochemical & Photobiological Sciences, photosensitiser stands only for systems which generate reactive oxygen species upon appropriate excitation and in suitable conditions. These papers focus on the design, synthesis and evaluation of such photosensitisers.

Photosensitising systems involve an infinite variety of molecular and nano-structures and involve multiple mechanisms of action. They are used in medicine as photodynamic therapy treatment for cancer but also have activity against infections and optical diseases, and are used in the environment for water decontamination, etc. Different excitation modes, ranging from visible light to X-ray, need specific photosensitising structures.

The role of the engineer, often but not always a chemist, is crucial in the development of new photosensitisers. This is highlighted in this issue which is a collection of reviews and research articles from around the world.  As for light, the topic has indeed no frontiers!

Fabienne Dumoulin (Guest Editor)

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