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Themed collection Celebrating the RAOBC symposium

19 items
Review Article

Fluorescent probes for hydrogen polysulfides (H2Sn, n > 1): from design rationale to applications

Hydrogen polysulfides (H2Sn, n > 1) are gaining much research interest due to their involvement in signaling and cytoprotection. The present review highlights recent advances in the design of fluorescent probes for the detection of H2Sn along with the fundamental challenges and future prospects in this field.

Graphical abstract: Fluorescent probes for hydrogen polysulfides (H2Sn, n > 1): from design rationale to applications
From the themed collection: Celebrating the RAOBC symposium
Review Article

ipso-Cyclization: an emerging tool for multifunctional spirocyclohexadienones

Various ipso-annulation strategies to access diversely substituted spirocyclohexadienones and their applications have been presented.

Graphical abstract: ipso-Cyclization: an emerging tool for multifunctional spirocyclohexadienones
From the themed collection: Celebrating the RAOBC symposium
Review Article

C–H imidation: a distinct perspective of C–N bond formation

The direct imidation strategy proficiently constructs C–N bonds and creates the useful amine functional group in the molecular template.

Graphical abstract: C–H imidation: a distinct perspective of C–N bond formation
From the themed collection: Celebrating the RAOBC symposium
Communication

Aldehydes can switch the chemoselectivity of electrophiles in protein labeling

The derivatization of an electrophile can switch its chemoselectivity. The aldehyde-conjugated epoxide and sulfonate ester provide the proof of principle and deliver N-terminus tagged proteins.

Graphical abstract: Aldehydes can switch the chemoselectivity of electrophiles in protein labeling
From the themed collection: Chemical biology in OBC
Communication

A cascade synthesis of S-allyl benzoylcarbamothioates via Mumm-type rearrangement

A cascade synthesis of S-allyl benzoylcarbamothioates has been achieved from Morita Baylis Hillman alcohols and aroyl isothiocyanates via Mumm-type rearrangement.

Graphical abstract: A cascade synthesis of S-allyl benzoylcarbamothioates via Mumm-type rearrangement
From the themed collection: Synthetic methodology in OBC
Communication

Facile synthesis of triphenylenes and triphenylene/phenanthrene fused heteroaromatics

Facile synthesis of triphenylene fused imidazoles, quinoxaline and phenanthro[9,10-d]-fused pyrazines via CAN-mediated oxidative cyclodehydrogenation.

Graphical abstract: Facile synthesis of triphenylenes and triphenylene/phenanthrene fused heteroaromatics
From the themed collection: Synthetic methodology in OBC
Communication

Gold(I)-catalyzed cross-coupling reactions of aryldiazonium salts with organostannanes

Gold(I)-catalyzed cross-coupling reactions of aryldiazonium salts with organostannanes are described.

Graphical abstract: Gold(i)-catalyzed cross-coupling reactions of aryldiazonium salts with organostannanes
From the themed collection: Celebrating the RAOBC symposium
Paper

Programmed synthesis of triarylnitroimidazoles via sequential cross-coupling reactions

Transition-metal-catalyzed programmed sequential arylation of 2-chloro-4-nitro-1H-imidazoles was achieved.

Graphical abstract: Programmed synthesis of triarylnitroimidazoles via sequential cross-coupling reactions
From the themed collection: Celebrating the RAOBC symposium
Paper

Regiospecific formal [3 + 2] annulation of tert-propargyl alcohols with acyclic 1,3-diketones via the cycloisomerization of homoallenyl ketones

A one-pot, regiospecific synthesis of dihydrofurans bearing a quaternary centre is developed from the formal [3 + 2] annulation of tert-propargyl alcohols and 1,3-diketones through the SN2I mechanism to form homoallenyl ketone and a subsequent cycloisomerization reaction.

Graphical abstract: Regiospecific formal [3 + 2] annulation of tert-propargyl alcohols with acyclic 1,3-diketones via the cycloisomerization of homoallenyl ketones
From the themed collection: Synthetic methodology in OBC
Paper

Synthesis of quinazoline-3-oxides via a Pd(II) catalyzed azide–isocyanide coupling/cyclocondensation reaction

One-pot three-component synthesis of quinazoline 3-oxides promoted by single Pd(II) catalysis under mild reaction conditions.

Graphical abstract: Synthesis of quinazoline-3-oxides via a Pd(ii) catalyzed azide–isocyanide coupling/cyclocondensation reaction
From the themed collection: Catalysis & biocatalysis in OBC
Paper

L-Dopa and dopamine conjugated naphthalenediimides modulate amyloid β toxicity

We report amino acid, L-dopa and dopamine functionalised naphthalenediimides (NDIs) and the detailed in silico and in vitro studies to identify potential multifunctional modulators of amyloid β toxicity.

Graphical abstract: l-Dopa and dopamine conjugated naphthalenediimides modulate amyloid β toxicity
From the themed collection: Chemical biology in OBC
Paper

Enantioselective 1,4-Michael addition reaction of pyrazolin-5-one derivatives with 2-enoylpyridines catalyzed by Cinchona derived squaramides

Cinchonidine derived squaramide catalyzed Michael addition of pyrazolin-5-ones to 2-enoylpyridines providing chiral molecules bearing two heterocyclic motifs with enantiomeric excess up to 96%.

Graphical abstract: Enantioselective 1,4-Michael addition reaction of pyrazolin-5-one derivatives with 2-enoylpyridines catalyzed by Cinchona derived squaramides
From the themed collection: Synthetic methodology in OBC
Paper

A quantification scheme for non-covalent interactions in the enantio-controlling transition states in asymmetric catalysis

A simple quantification scheme for estimating the strength of non-covalent interactions in the enantio-controlling transition states is proposed.

Graphical abstract: A quantification scheme for non-covalent interactions in the enantio-controlling transition states in asymmetric catalysis
From the themed collection: Celebrating the RAOBC symposium
Paper

Highly regioselective, electrophile induced cyclizations of 2-(prop-1-ynyl)benzamides

We report an electrophile promoted, highly regioselective (∼100%) synthesis of 5-membered haloimidiates from 2-(1-alkynyl)benzamides under metal free conditions.

Graphical abstract: Highly regioselective, electrophile induced cyclizations of 2-(prop-1-ynyl)benzamides
From the themed collection: Celebrating the RAOBC symposium
Paper

An expeditious route to the synthesis of the enantioenriched tetracyclic core of ergot alkaloids via an organocatalytic aldol reaction

A concise route to the synthesis of the enantiopure tetracyclic scaffold of ergot alkaloids has been developed via a key organocatalytic aldol reaction using paraformaldehyde as the C1-unit in the presence of thiourea ligand followed by a Pd-catalyzed directed coupling.

Graphical abstract: An expeditious route to the synthesis of the enantioenriched tetracyclic core of ergot alkaloids via an organocatalytic aldol reaction
From the themed collection: Celebrating the RAOBC symposium
Paper

Synthesis of Cu-catalysed quinazolinones using a Csp3–H functionalisation/cyclisation strategy

A series of 2,3-disubstituted-4(3H)-quinazolinones were synthesised via a copper-catalysed Csp3–H functionalisation/cyclisation of 2-amino-N,N-dialkylbenzamides.

Graphical abstract: Synthesis of Cu-catalysed quinazolinones using a Csp3–H functionalisation/cyclisation strategy
From the themed collection: Celebrating the RAOBC symposium
Paper

“On water” catalytic enantioselective sulfenylation of deconjugated butyrolactams

The first catalytic enantioselective α-sulfenylation of deconjugated butyrolactams has been developed using dimeric cinchona alkaloids as catalysts in water-enriched reaction medium. The applicability of the same catalyst system for enantioselective α-selenylation and formal vinylogous γ-hydroxylation of deconjugated butyrolactam has also been described.

Graphical abstract: “On water” catalytic enantioselective sulfenylation of deconjugated butyrolactams
From the themed collection: Celebrating the RAOBC symposium
Paper

Construction of thiazines and oxathianes via [3 + 3] annulation of N-tosylaziridinedicarboxylates and oxiranes with 1,4-dithiane-2,5-diol: application towards the synthesis of bioactive molecules

Efficient construction of functionalized thiazine and oxathiane derivatives via [3 + 3] annulation of N-tosylaziridinedicarboxylates and oxiranes with in situ generated mercaptoaldehyde in the presence of a Lewis acid is described.

Graphical abstract: Construction of thiazines and oxathianes via [3 + 3] annulation of N-tosylaziridinedicarboxylates and oxiranes with 1,4-dithiane-2,5-diol: application towards the synthesis of bioactive molecules
From the themed collection: Celebrating the RAOBC symposium
Paper

Intramolecular Minisci acylation under silver-free neutral conditions for the synthesis of azafluorenones and fluorenones

An intramolecular Minisci acylation under silver-free neutral conditions providing access to azafluorenones and fluorenones has been developed.

Graphical abstract: Intramolecular Minisci acylation under silver-free neutral conditions for the synthesis of azafluorenones and fluorenones
From the themed collection: Celebrating the RAOBC symposium
19 items

About this collection

The Recent Advances in Organic and Bio-organic Chemistry (RAOBC) Symposium, held last month at IISER Mohali, gave a platform to dynamic researchers in organic, bioorganic and medicinal chemistry to share their innovations and inspire fellow researchers. We are delighted to showcase the excellent research being carried out by the RAOBC speakers with this thematic collection, highlighting the fantastic work they have presented in Organic & Biomolecular Chemistry from 2017-2019. We hope you enjoy reading these articles.

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