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Issue 8, 2019
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Programmed synthesis of triarylnitroimidazoles via sequential cross-coupling reactions

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Abstract

Transition-metal-catalyzed programmed sequential arylation reactions of 2-chloro-4-nitro-1H-imidazoles were achieved. The methods are general and were applied in a chemoselective manner for the synthesis of different multiarylated 4-nitroimidazoles bearing three different aryl groups. A salient feature is Pd-catalyzed hetero–hetero coupling at the C5 position through a NO2 directed cross-dehydrogenative coupling (CDC) approach.

Graphical abstract: Programmed synthesis of triarylnitroimidazoles via sequential cross-coupling reactions

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Publication details

The article was received on 10 Oct 2018, accepted on 22 Jan 2019 and first published on 22 Jan 2019


Article type: Paper
DOI: 10.1039/C9OB00144A
Citation: Org. Biomol. Chem., 2019,17, 2134-2147

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    Programmed synthesis of triarylnitroimidazoles via sequential cross-coupling reactions

    G. Raina, P. Kannaboina, N. Mupparapu, S. Raina, Q. N. Ahmed and P. Das, Org. Biomol. Chem., 2019, 17, 2134
    DOI: 10.1039/C9OB00144A

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