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Themed collection Dendritic Polymers for Smart Drug Delivery Applications

13 items
Editorial

Dendritic polymers for smart drug delivery applications

This themed issue presents a collection of articles on dendritic polymers for smart drug delivery applications.

Graphical abstract: Dendritic polymers for smart drug delivery applications
Minireview

Nanoparticle-cored dendrimers: functional hybrid nanocomposites as a new platform for drug delivery systems

Nanoparticle-cored dendrimers (NCDs) are now offering themselves as versatile carriers because of their colloidal stability, tunable membrane properties and ability to encapsulate or integrate a broad range of drugs and molecules.

Graphical abstract: Nanoparticle-cored dendrimers: functional hybrid nanocomposites as a new platform for drug delivery systems
Minireview

Experimental and theoretical investigations in stimuli responsive dendrimer-based assemblies

Stimuli-responsive macromolecular assemblies are of great interest in drug delivery applications, as it holds the promise to keep the drug molecules sequestered under one set of conditions and release them under another.

Graphical abstract: Experimental and theoretical investigations in stimuli responsive dendrimer-based assemblies
Open Access Paper

Dendritic polyglycerol sulfate as a novel platform for paclitaxel delivery: pitfalls of ester linkage

In this study, dendritic polyglycerol sulfate (dPGS) is evaluated as a delivery platform for the anticancer, tubulin-binding drug paclitaxel (PTX).

Graphical abstract: Dendritic polyglycerol sulfate as a novel platform for paclitaxel delivery: pitfalls of ester linkage
Paper

In situ nanofabrication of hybrid PEG-dendritic–inorganic nanoparticles and preliminary evaluation of their biocompatibility

An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio.

Graphical abstract: In situ nanofabrication of hybrid PEG-dendritic–inorganic nanoparticles and preliminary evaluation of their biocompatibility
Paper

Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs

Potent anticancer agents.

Graphical abstract: Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs
Paper

Topical gene silencing by iontophoretic delivery of an antisense oligonucleotide–dendrimer nanocomplex: the proof of concept in a skin cancer mouse model

Topical iontophoretic delivery of a dendrimer–antisense oligonucleotide nanocomplex demonstrates the potential for developing gene silencing therapy for skin diseases.

Graphical abstract: Topical gene silencing by iontophoretic delivery of an antisense oligonucleotide–dendrimer nanocomplex: the proof of concept in a skin cancer mouse model
Paper

Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy

A single agent-based theranostic nanoplatform was developed for concurrent NIR fluorescence imaging and combinatorial phototherapy with dual photodynamic (PDT) and photothermal (PTT) therapeutic mechanisms.

Graphical abstract: Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy
Open Access Paper

Dendritic polymer imaging systems for the evaluation of conjugate uptake and cleavage

A FRET-based imaging system was developed to evaluate polymer uptake and intracellular release of cargo in a cell based microplate assay that is suitable for high throughput screening.

Graphical abstract: Dendritic polymer imaging systems for the evaluation of conjugate uptake and cleavage
Paper

Cationic carbosilane dendrimers and oligonucleotide binding: an energetic affair

Molecular simulations individuate the normalized effective free energy of binding as a critical molecular parameter in designing efficient nanovectors for gene delivery.

Graphical abstract: Cationic carbosilane dendrimers and oligonucleotide binding: an energetic affair
Paper

Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrimer

An arginine-decorated amphiphilic dendrimer is able to promote enhanced cellular uptake of siRNA, leading to considerably improved siRNA delivery and gene silencing.

Graphical abstract: Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrimer
Paper

Use of carbosilane dendrimer to switch macrophage polarization for the acquisition of antitumor functions

The carbosilane dendrimer 2G-03NN24 switches macrophage polarization by inducing the acquisition of pro-inflammatory and tumoricidal functions in M2-polarized macrophages.

Graphical abstract: Use of carbosilane dendrimer to switch macrophage polarization for the acquisition of antitumor functions
Paper

Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells

Hydroxyl PAMAM dendrimer-based gene vectors with tailored surface characteristics demonstrate improved cell uptake and transfection of human RPE cells.

Graphical abstract: Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells
13 items

About this collection

This Nanoscale themed collection includes high quality articles highlighting developments in the field of dendritic polymers, their applications as controlled delivery of drugs and for diagnostic implications. This issue is Guest Edited by Professors Marcelo Calderón and Jayant Khandare.

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