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Dendritic polymers for smart drug delivery applications
This themed issue presents a collection of articles on dendritic polymers for smart drug delivery applications.
Nanoparticle-cored dendrimers: functional hybrid nanocomposites as a new platform for drug delivery systems
Nanoparticle-cored dendrimers (NCDs) are now offering themselves as versatile carriers because of their colloidal stability, tunable membrane properties and ability to encapsulate or integrate a broad range of drugs and molecules.
Experimental and theoretical investigations in stimuli responsive dendrimer-based assemblies
Stimuli-responsive macromolecular assemblies are of great interest in drug delivery applications, as it holds the promise to keep the drug molecules sequestered under one set of conditions and release them under another.
Paper
Dendritic polyglycerol sulfate as a novel platform for paclitaxel delivery: pitfalls of ester linkage
In this study, dendritic polyglycerol sulfate (dPGS) is evaluated as a delivery platform for the anticancer, tubulin-binding drug paclitaxel (PTX).
In situ nanofabrication of hybrid PEG-dendritic–inorganic nanoparticles and preliminary evaluation of their biocompatibility
An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio.
Investigations on dendrimer space reveal solid and liquid tumor growth-inhibition by original phosphorus-based dendrimers and the corresponding monomers and dendrons with ethacrynic acid motifs
Potent anticancer agents.
Topical gene silencing by iontophoretic delivery of an antisense oligonucleotide–dendrimer nanocomplex: the proof of concept in a skin cancer mouse model
Topical iontophoretic delivery of a dendrimer–antisense oligonucleotide nanocomplex demonstrates the potential for developing gene silencing therapy for skin diseases.
Dendrimer-encapsulated naphthalocyanine as a single agent-based theranostic nanoplatform for near-infrared fluorescence imaging and combinatorial anticancer phototherapy
A single agent-based theranostic nanoplatform was developed for concurrent NIR fluorescence imaging and combinatorial phototherapy with dual photodynamic (PDT) and photothermal (PTT) therapeutic mechanisms.
Paper
Dendritic polymer imaging systems for the evaluation of conjugate uptake and cleavage
A FRET-based imaging system was developed to evaluate polymer uptake and intracellular release of cargo in a cell based microplate assay that is suitable for high throughput screening.
Cationic carbosilane dendrimers and oligonucleotide binding: an energetic affair
Molecular simulations individuate the normalized effective free energy of binding as a critical molecular parameter in designing efficient nanovectors for gene delivery.
Promoting siRNA delivery via enhanced cellular uptake using an arginine-decorated amphiphilic dendrimer
An arginine-decorated amphiphilic dendrimer is able to promote enhanced cellular uptake of siRNA, leading to considerably improved siRNA delivery and gene silencing.
Use of carbosilane dendrimer to switch macrophage polarization for the acquisition of antitumor functions
The carbosilane dendrimer 2G-03NN24 switches macrophage polarization by inducing the acquisition of pro-inflammatory and tumoricidal functions in M2-polarized macrophages.
Hydroxyl PAMAM dendrimer-based gene vectors for transgene delivery to human retinal pigment epithelial cells
Hydroxyl PAMAM dendrimer-based gene vectors with tailored surface characteristics demonstrate improved cell uptake and transfection of human RPE cells.
About this collection
This Nanoscale themed collection includes high quality articles highlighting developments in the field of dendritic polymers, their applications as controlled delivery of drugs and for diagnostic implications. This issue is Guest Edited by Professors Marcelo Calderón and Jayant Khandare.