Issue 9, 2015
From the journal:

Nanoscale

In situ nanofabrication of hybrid PEG-dendritic–inorganic nanoparticles and preliminary evaluation of their biocompatibility†

Ana Sousa-Herves,a   Christian Sánchez Espinel,b   Amir Fahmi,*c   África González-Fernández*d  and  Eduardo Fernandez-Megia*a  

* Corresponding authors

a Department of Organic Chemistry and Center for Research in Biological Chemistry and Molecular Materials (CIQUS), University of Santiago de Compostela, Jenaro de la Fuente s/n, Santiago de Compostela, Spain
E-mail: ef.megia@usc.es
Tel: +34 8818 15727

b NanoImmunoTech (NIT) Edificio CITEXVI, Fonte das Abelleiras, Vigo, Spain

c Faculty of Technology and Bionics, Rhein-Waal University of Applied Sciences, Marie-Curie-Straße 1, D-47533 Kleve, Germany
E-mail: Amir.Fahmi@hochschule-rhein-waal.de

d Immunology, Institute of Biomedical Research (IBI), Biomedical Research Center (CINBIO), University of Vigo, Campus Lagoas Marcosende, Vigo, Spain
E-mail: africa@uvigo.es
Tel: +34 986 812625

Abstract

An in situ template fabrication of inorganic nanoparticles using carboxylated PEG-dendritic block copolymers of the GATG family is described as a function of the dendritic block generation, the metal (Au, CdSe) and metal molar ratio. The biocompatibility of the generated nanoparticles analysed in terms of their aggregation in physiological media, cytotoxicity and uptake by macrophages relates to the PEG density of the surface of the hybrids.

Graphical abstract: In situ nanofabrication of hybrid PEG-dendritic–inorganic nanoparticles and preliminary evaluation of their biocompatibility

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Article information

DOI
https://doi.org/10.1039/C4NR06155A
Article type
Paper
Submitted
18 Oct 2014
Accepted
07 Dec 2014
First published
08 Dec 2014

Nanoscale, 2015,7, 3933-3940

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In situ nanofabrication of hybrid PEG-dendritic–inorganic nanoparticles and preliminary evaluation of their biocompatibility

A. Sousa-Herves, C. Sánchez Espinel, A. Fahmi, Á. González-Fernández and E. Fernandez-Megia, Nanoscale, 2015, 7, 3933 DOI: 10.1039/C4NR06155A

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