Themed collection Synthetic strategies for mining the information-rich content of natural products
Synthetic strategies for mining the information-rich content of natural products for biology and medicine
The Natural Product Reports themed collection on Synthetic Strategies for Mining the Information-Rich Content of Natural Products for Biology and Medicine is introduced by the Guest Editors, Daniel Romo and Christopher D. Vanderwal.
Nat. Prod. Rep., 2020,37, 1393-1394
https://doi.org/10.1039/D0NP90042G
Cheminformatic analysis of natural product-based drugs and chemical probes
Cheminformatic analyses illustrate that drugs from natural product-based and synthetic origins have distinctive structural and physicochemical features. These drugs also cluster by biosynthetic origin and, to some extent, by therapeutic class.
Nat. Prod. Rep., 2022,39, 20-32
https://doi.org/10.1039/D1NP00039J
Re-engineering natural products to engage new biological targets
Incorporating natural product-like features within small-molecule screening collections is of great interest. We highlight an emerging strategy that achieves this goal by using abundant natural products as starting points for compound construction.
Nat. Prod. Rep., 2020,37, 1395-1403
https://doi.org/10.1039/D0NP00059K
Synthesis of rearranged indole diterpenes of the paxilline type
Paxilline indole diterpenes have fascinated chemists for the past several decades. This review highlights the diversity of strategies and tactics that have been employed in the corresponding area of organic synthesis, from inception to the present.
Nat. Prod. Rep., 2022,39, 946-968
https://doi.org/10.1039/D1NP00062D
Employing chemical synthesis to study the structure and function of colibactin, a “dark matter” metabolite
This review recounts the chemical journey from 2015 to 2020 that culminated in the structure elucidation of the elusive bacterial metabolite, colibactin.
Nat. Prod. Rep., 2020,37, 1532-1548
https://doi.org/10.1039/D0NP00072H
The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry
This review summarizes and highlights recent advances in medicinal chemistry of natural products enabled by total synthesis that provide “supernatural products” with improved properties superseding the natural products themselves.
Nat. Prod. Rep., 2020,37, 1511-1531
https://doi.org/10.1039/D0NP00060D
Bridging the gap between natural product synthesis and drug discovery
Various synthetic strategies have been developed to explore natural products as an enduring source of chemical information useful for probing biological relevant chemical space and impacting drug discovery.
Nat. Prod. Rep., 2020,37, 1436-1453
https://doi.org/10.1039/D0NP00048E
Guided by evolution: from biology oriented synthesis to pseudo natural products
This review provides an overview and historical context to two concepts for the design of natural product-inspired compound libraries and highlights the used synthetic methodologies.
Nat. Prod. Rep., 2020,37, 1497-1510
https://doi.org/10.1039/D0NP00015A
Chemical syntheses of the salvinorin chemotype of KOR agonist
Chemical syntheses of the salvinorin chemotype analyzed through the lens of chemical space navigation.
Nat. Prod. Rep., 2020,37, 1478-1496
https://doi.org/10.1039/D0NP00028K
Natural products as inspiration for the development of bacterial antibiofilm agents
Synthetic and medicinal chemistry are important tools in the development of more potent, more accessible, or more pharmacologically favorable derivatives of anti-biofilm natural products, in addition to facilitating structure confirmation and understanding of mechanistic pathways.
Nat. Prod. Rep., 2020,37, 1454-1477
https://doi.org/10.1039/D0NP00022A
Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine
This review article summarises a series of total syntheses of natural and designed molecules primarily for biology and medicine. Aspects of new synthetic strategies and methods and optimisation of biological properties are emphasised.
Nat. Prod. Rep., 2020,37, 1404-1435
https://doi.org/10.1039/D0NP00003E
About this collection
This themed issue is Guest Edited by Professor Christopher Vanderwal and Professor Daniel Romo.