Synthetic strategies for mining the information-rich content of natural products for biology and medicine
The Natural Product Reports themed collection on Synthetic Strategies for Mining the Information-Rich Content of Natural Products for Biology and Medicine is introduced by the Guest Editors, Daniel Romo and Christopher D. Vanderwal.
Re-engineering natural products to engage new biological targets
Incorporating natural product-like features within small-molecule screening collections is of great interest. We highlight an emerging strategy that achieves this goal by using abundant natural products as starting points for compound construction.
Employing chemical synthesis to study the structure and function of colibactin, a “dark matter” metabolite
This review recounts the chemical journey from 2015 to 2020 that culminated in the structure elucidation of the elusive bacterial metabolite, colibactin.
The quest for supernatural products: the impact of total synthesis in complex natural products medicinal chemistry
This review summarizes and highlights recent advances in medicinal chemistry of natural products enabled by total synthesis that provide “supernatural products” with improved properties superseding the natural products themselves.
Bridging the gap between natural product synthesis and drug discovery
Various synthetic strategies have been developed to explore natural products as an enduring source of chemical information useful for probing biological relevant chemical space and impacting drug discovery.
Guided by evolution: from biology oriented synthesis to pseudo natural products
This review provides an overview and historical context to two concepts for the design of natural product-inspired compound libraries and highlights the used synthetic methodologies.
Chemical syntheses of the salvinorin chemotype of KOR agonist
Chemical syntheses of the salvinorin chemotype analyzed through the lens of chemical space navigation.
Natural products as inspiration for the development of bacterial antibiofilm agents
Synthetic and medicinal chemistry are important tools in the development of more potent, more accessible, or more pharmacologically favorable derivatives of anti-biofilm natural products, in addition to facilitating structure confirmation and understanding of mechanistic pathways.
Perspectives from nearly five decades of total synthesis of natural products and their analogues for biology and medicine
This review article summarises a series of total syntheses of natural and designed molecules primarily for biology and medicine. Aspects of new synthetic strategies and methods and optimisation of biological properties are emphasised.
About this collection
This themed issue is Guest Edited by Professor Christopher Vanderwal and Professor Daniel Romo.