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Themed collection Metalloenzymes in Natural Product Biosynthetic Pathways

15 items
Cover

Front cover

Graphical abstract: Front cover
Cover

Front cover

Graphical abstract: Front cover
Editorial

Metalloenzymes in natural product biosynthetic pathways

The Natural Product Reports themed issue on ‘Metalloenzymes in natural product biosynthetic pathways’ is introduced by the Guest Editors, Katherine Ryan and Catherine Drennan.

Graphical abstract: Metalloenzymes in natural product biosynthetic pathways
Viewpoint

Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes

Electrons do not always go where you expect them to in the catalytic cycles of radical SAM enzymes. Herein, a number of examples are considered along with potential avenues for future investigation.

Graphical abstract: Following the electrons: peculiarities in the catalytic cycles of radical SAM enzymes
Highlight

Cobalamin-dependent radical S-adenosyl-L-methionine enzymes in natural product biosynthesis

This highlight examines the functions of cobalamin-dependent radical S-adenosyl-L-methionine enzymes that catalyse chemically-challenging reactions in several bacterial natural product biosynthetic pathways.

Graphical abstract: Cobalamin-dependent radical S-adenosyl-l-methionine enzymes in natural product biosynthesis
Highlight

Expanding the roles for 2-oxoglutarate-dependent oxygenases in plant metabolism

This review of 2-oxoglutarate-dependent oxygenases and other oxidases involved in plant metabolism provides a framework for continued enzyme discovery.

Graphical abstract: Expanding the roles for 2-oxoglutarate-dependent oxygenases in plant metabolism
Highlight

Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis

The role played by Rieske non-heme iron-dependent oxygenases in natural product biosyntheses is reviewed, with particular focus on experimentally characterised examples.

Graphical abstract: Rieske non-heme iron-dependent oxygenases catalyse diverse reactions in natural product biosynthesis
Open Access Review Article

Metabolic functions of the human gut microbiota: the role of metalloenzymes

Metalloenzymes play central roles in metabolic functions of the human gut microbiota that are associated with host health and disease.

Graphical abstract: Metabolic functions of the human gut microbiota: the role of metalloenzymes
Review Article

Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses

Proximal- and distal-type αKG binding to the Fe(II) centre might play a crucial role in fine-tuning the catalysis of αKG-dependent non-haem iron enzymes.

Graphical abstract: Recent examples of α-ketoglutarate-dependent mononuclear non-haem iron enzymes in natural product biosyntheses
Open Access Review Article

Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis

The 2OG oxygenases and IPNS contribute to the great structural diversity of β-lactam natural products, employing some remarkable mechanisms.

Graphical abstract: Roles of 2-oxoglutarate oxygenases and isopenicillin N synthase in β-lactam biosynthesis
Open Access Review Article

Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism

This review highlights the scope of chemical transformations that cytochrome P450 enzymes catalyse within bacterial secondary metabolism.

Graphical abstract: Unrivalled diversity: the many roles and reactions of bacterial cytochromes P450 in secondary metabolism
Review Article

C–C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products

An emerging group of radical SAM enzymes that catalyze C–C bond formations in natural product and cofactor biosynthesis are discussed.

Graphical abstract: C–C bond forming radical SAM enzymes involved in the construction of carbon skeletons of cofactors and natural products
Review Article

Diiron monooxygenases in natural product biosynthesis

Two new families of diiron cluster-containing oxygenases serve as tailoring enzymes for NRPS and PKS biosynthetic systems.

Graphical abstract: Diiron monooxygenases in natural product biosynthesis
Review Article

Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways

Reactions by non-heme iron enzymes in structurally intriguing fungal natural products pathways are summarized and discussed.

Graphical abstract: Unique chemistry of non-heme iron enzymes in fungal biosynthetic pathways
Review Article

Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function

This review catalogues functionally characterized P450s from Streptomyces and discusses their sequences, structures, and functions in natural products biosynthesis.

Graphical abstract: Cytochromes P450 for natural product biosynthesis in Streptomyces: sequence, structure, and function
15 items

About this collection

Natural Product Reports is delighted to present a themed issue dedicated to the role of metal-containing enzymes in natural product biosynthetic pathways, Guest Edited by Professors Catherine Drennan (MIT) and Katherine Ryan (The University of British Columbia).

Metal-containing enzymes are critical for catalysing challenging chemical transformations needed to build up structurally diverse natural products. In this themed issue, we will highlight the major classes of metalloenzymes that are used in natural products biosynthesis, including cytochrome P450s, radical SAM-dependent enzymes, and iron(II) α-keto-glutarate-dependent enzymes. These reviews discuss these enzymes in the context of pathways found in bacteria, fungi, and plants. The reviews also discuss the data key to unveiling the mechanisms of these enzymes and efforts to expand the chemistry of metalloenzymes from natural product biosynthesis using engineering approaches.

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