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Themed collection Synthesis III

16 items
Editorial

Finding function and form

Graphical abstract: Finding function and form
From the themed collection: Synthesis III
Highlight

The ever-expanding role of asymmetric covalent organocatalysis in scalable, natural product synthesis

This Highlight provides a brief overview of covalent, asymmetric modes of organocatalysis and applications of scalable versions of these methods applied to the total synthesis of natural products.

Graphical abstract: The ever-expanding role of asymmetric covalent organocatalysis in scalable, natural product synthesis
From the themed collection: Synthesis III
Highlight

Efficient synthesis strategies by application of transition metal-catalyzed carbene/nitrene insertions into C–H bonds

This Highlight article provides an overview of recent total syntheses that are characterized by high efficiency and enabled through a neat application of transition metal-catalyzed insertions of carbenes and nitrenes into C–H bonds.

Graphical abstract: Efficient synthesis strategies by application of transition metal-catalyzed carbene/nitrene insertions into C–H bonds
From the themed collection: Synthesis III
Open Access Highlight

Toward the ideal synthesis and molecular function through synthesis-informed design

This Highlight describes factors that contribute to an ideal synthesis, including economies (step, time, atom, solvent, energy) and orientations (target, diversity, safety, function), and the role of synthesis-informed design directed at function in advancing synthesis and its impact on science.

Graphical abstract: Toward the ideal synthesis and molecular function through synthesis-informed design
From the themed collection: Synthesis III
Highlight

sp3-sp3 Coupling reactions in the synthesis of natural products and biologically active molecules

This Highlight covers the current status of relatively unexplored sp3–sp3 cross-coupling reactions with particular focus on natural product and related syntheses.

Graphical abstract: sp3-sp3 Coupling reactions in the synthesis of natural products and biologically active molecules
From the themed collection: Synthesis III
Highlight

Natural product synthesis in the age of scalability

In this Highlight, we discuss recent examples of natural product synthesis from our laboratory and others, where the preparation of gram-scale quantities of a target compound or a key intermediate allowed for a deeper understanding of biological activities or enabled further investigational collaborations. (Picture courtesy of Frank Fang of Eisai Inc.)

Graphical abstract: Natural product synthesis in the age of scalability
From the themed collection: Synthesis III
Review Article

Strategies towards the synthesis of calyciphylline A-type Daphniphyllum alkaloids

The structurally unique calyciphylline A-type Daphniphyllum alkaloids have recently attracted the interest of natural product synthesis groups, due to the challenge posed by the complex structural framework. Recently, several noteworthy core syntheses were reported using a variety of novel synthetic strategies, which include intramolecular Michael addition, Pd-catalysis, cycloaddition and Mannich-type reactions.

Graphical abstract: Strategies towards the synthesis of calyciphylline A-type Daphniphyllum alkaloids
From the themed collection: Synthesis III
Review Article

The vinylogous Mukaiyama aldol reaction (VMAR) in natural product synthesis

This review will provide an overview on the recent developments of polyketide synthesis using the vinylogous Mukaiyama aldol reaction for the construction of advanced intermediates. In general, four different motifs can be constructed efficiently using the recent developments of asymmetric variants of this strategy.

Graphical abstract: The vinylogous Mukaiyama aldol reaction (VMAR) in natural product synthesis
From the themed collection: Synthesis III
Review Article

Trying to rationalize total synthesis

The crux in multistep natural product synthesis is the exponential decrease of the yield with the number of steps. In this article various strategies are explained on how to circumvent this problem and to achieve efficient approaches nevertheless.

Graphical abstract: Trying to rationalize total synthesis
From the themed collection: Synthesis III
Review Article

Cu-mediated enamide formation in the total synthesis of complex peptide natural products

This review covers the synthetic assembly of peptide natural products in which a Cu-mediated C(sp2)–N bond formation is the key transformation, and particularly focuses on the total syntheses of cyclopeptide alkaloids, pacidamycin D, and yaku'amide A.

Graphical abstract: Cu-mediated enamide formation in the total synthesis of complex peptide natural products
From the themed collection: Synthesis III
Review Article

Isolation, structural determination and synthetic approaches toward amphidinol 3

This review highlights the isolation and the structural determination of amphidinol 3 (AM3) with an emphasis on the different synthetic approaches.

Graphical abstract: Isolation, structural determination and synthetic approaches toward amphidinol 3
From the themed collection: Synthesis III
Review Article

Polyketide construction via hydrohydroxyalkylation and related alcohol C–H functionalizations: reinventing the chemistry of carbonyl addition

Direct alcohol C–H bond functionalization bypasses the use of chiral auxiliaries, premetallated C-nucleophiles, and discrete alcohol-to-aldehyde redox reactions. This technology has enabled syntheses of 6-deoxyerythronolide B, bryostatin 7, trienomycins A and F, cyanolide A, roxaticin.

Graphical abstract: Polyketide construction via hydrohydroxyalkylation and related alcohol C–H functionalizations: reinventing the chemistry of carbonyl addition
From the themed collection: Synthesis III
Review Article

Transition metal-promoted biomimetic steps in total syntheses

Important biomimetic steps in natural product synthesis have been promoted by transition metals, as exemplified by this beautiful ruthenium-catalyzed rearrangement of an endoperoxide into elysiapyrone A. Such reactions are supposed to occur during the biosynthesis, yet under different catalysis conditions.

Graphical abstract: Transition metal-promoted biomimetic steps in total syntheses
From the themed collection: Synthesis III
Review Article

Strategic innovation in the total synthesis of complex natural products using gold catalysis

This review has been organized from the perspective of synthetic target families, with emphasis on the use of gold-catalyzed transformations and cascade reactions that significantly increase molecular complexity.

Graphical abstract: Strategic innovation in the total synthesis of complex natural products using gold catalysis
From the themed collection: Synthesis III
Review Article

Sequential catalysis for stereoselective synthesis of complex polyketides

This review presents selected recent advances in sequential catalytic methods developed in our group for the rapid and stereoselective synthesis of key structural features of complex polyketides and their successful application in complex target synthesis.

Graphical abstract: Sequential catalysis for stereoselective synthesis of complex polyketides
From the themed collection: Synthesis III
Hot off the Press Article

Hot off the press

A personal selection of 32 recent papers is presented covering various aspects of current developments in bioorganic chemistry and novel natural products such as thelepamide from Thelepus crispus.

Graphical abstract: Hot off the press
From the themed collection: Synthesis III
16 items

About this collection

Natural Product Reports is delighted to present its latest themed collection dedicated to Synthesis. Guest-edited by Professor Dirk Trauner (Ludwig-Maximilians-University Munich), the collection features contributions from leaders in the field, with a specific focus on the role of transition metals in natural products synthesis.

Articles in this web themed issue will be added below as soon as possible after they are published. Please return to this page frequently to see the collection grow.

We hope you enjoy this selection!

Also of interest:
    Synthesis, 2010
    Synthesis, 2008

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