Issue 4, 2014

Cu-mediated enamide formation in the total synthesis of complex peptide natural products

Abstract

Covering: up to the end of 2013

Cu-mediated C(sp2)–N bond formation has received intense interest recently, and has been applied to the total synthesis of a wide variety of structurally complex natural products. This review covers the synthetic assembly of peptide natural products in which Cu-mediated enamide formation is the key transformation. The total syntheses of cyclopeptide alkaloids, pacidamycin D, and yaku'amide A exemplify the versatility of the Cu-catalyzed cross-coupling reaction in comparison to other synthetic methods.

Graphical abstract: Cu-mediated enamide formation in the total synthesis of complex peptide natural products

Article information

Article type
Review Article
Submitted
25 Sep 2013
First published
25 Feb 2014

Nat. Prod. Rep., 2014,31, 514-532

Cu-mediated enamide formation in the total synthesis of complex peptide natural products

T. Kuranaga, Y. Sesoko and M. Inoue, Nat. Prod. Rep., 2014, 31, 514 DOI: 10.1039/C3NP70103D

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