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Themed collection Metallomics Emerging Investigators

16 items
Editorial

Metallomics: Emerging Investigators 2019

Welcome to this Metallomics themed issue highlighting the work of emerging investigators in metallomics, Guest Edited by Metallomics Editorial Board member Katherine Franz (Duke University, USA).

Graphical abstract: Metallomics: Emerging Investigators 2019
From the themed collection: Metallomics Emerging Investigators
Open Access Perspective

Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging

Taking a systems analytical approach to systems biology questions requires a network of multidimensional analytical tools to illuminate the many different functional and structural aspects of metals in biology.

Graphical abstract: Across the spectrum: integrating multidimensional metal analytics for in situ metallomic imaging
From the themed collection: Metallomics Emerging Investigators
Minireview

Zinc finger domains as therapeutic targets for metal-based compounds – an update

The design of novel metal-based compounds and the elucidation of the mechanisms of zinc substitution have renewed the possibilities of selective zinc-finger inhibition.

Graphical abstract: Zinc finger domains as therapeutic targets for metal-based compounds – an update
From the themed collection: Metallomics Emerging Investigators
Tutorial Review

Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology

Advances in understanding of hormones and metal micronutrients show critical interactions between the two in a newly-termed field of metalloendocrinology.

Graphical abstract: Metal-dependent hormone function: the emerging interdisciplinary field of metalloendocrinology
From the themed collection: Metallomics Emerging Investigators
Critical Review

Handling of nutrient copper in the bacterial envelope

The insertion of copper into bacterial cuproenzymes in vivo does not always require a copper-binding metallochaperone – why?

Graphical abstract: Handling of nutrient copper in the bacterial envelope
From the themed collection: Metallomics Emerging Investigators
Critical Review

Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers

The coordination chemistry of transition metal ions (Fe, Cu, Zn) with the amyloid-β (Aβ) peptides has attracted a lot of attention in recent years due to its repercussions in Alzheimer's disease (AD).

Graphical abstract: Cu and Zn interactions with Aβ peptides: consequence of coordination on aggregation and formation of neurotoxic soluble Aβ oligomers
From the themed collection: Metallomics Emerging Investigators
Paper

Cytoprotective effects of imidazole-based [S1] and [S2]-donor ligands against mercury toxicity: a bioinorganic approach

[S2]-Donor ligands L2 and L3 showed remarkable ability to protect liver cell against HgCl2 induced toxicity and the strength of their efficacy is in the order of L3 > L2 > L1. Interestingly, 60% decrease of ROS production was observed in liver cells co-treated with HgCl2 and L3 in comparison to the cells treated with HgCl2 only.

Graphical abstract: Cytoprotective effects of imidazole-based [S1] and [S2]-donor ligands against mercury toxicity: a bioinorganic approach
From the themed collection: Metallomics Emerging Investigators
Paper

Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn

The binding of Cu, Fe or Zn to alpha-synuclein has been implicated in neurodegenerative disease, such as Parkinson's.

Graphical abstract: Characterization of the metal status of natively purified alpha-synuclein from human blood, brain tissue, or recombinant sources using size exclusion ICP-MS reveals no significant binding of Cu, Fe or Zn
From the themed collection: Metallomics Emerging Investigators
Paper

Genetic, structural, and functional diversity of low and high-affinity siderophores in strains of nitrogen fixing Azotobacter chroococcum

Conserved patterns of siderophore production by Azotobacters related to siderophore gene evolution and Fe bioavailability.

Graphical abstract: Genetic, structural, and functional diversity of low and high-affinity siderophores in strains of nitrogen fixing Azotobacter chroococcum
From the themed collection: Metallomics Emerging Investigators
Open Access Paper

Copper stress in Staphylococcus aureus leads to adaptive changes in central carbon metabolism

Pathogenic Staphylococcus aureus respond to copper stress by altering central carbon metabolism in response to a specific inhibition of the glycolytic enzyme, glyceraldehyde-3-phosphate dehydrogenase.

Graphical abstract: Copper stress in Staphylococcus aureus leads to adaptive changes in central carbon metabolism
From the themed collection: Metallomics Emerging Investigators
Paper

Inhibition of arsenite methylation induces synergistic genotoxicity of arsenite and benzo(a)pyrene diol epoxide in SCC-7 cells

A comprehensive analytical method was developed to investigate the synergistic genotoxicity of BPDE and As(III) in SCC-7 cells.

Graphical abstract: Inhibition of arsenite methylation induces synergistic genotoxicity of arsenite and benzo(a)pyrene diol epoxide in SCC-7 cells
From the themed collection: Metallomics Emerging Investigators
Paper

Siderophore profiling of co-habitating soil bacteria by ultra-high resolution mass spectrometry

Calcareous soil microbes complete for scarce iron by synthesizing diverse suites of siderophores detectable by ultra-high resolution mass spectrometry.

Graphical abstract: Siderophore profiling of co-habitating soil bacteria by ultra-high resolution mass spectrometry
From the themed collection: Metallomics Emerging Investigators
Open Access Paper

Elemental characterisation of the pyramidal neuron layer within the rat and mouse hippocampus

X-ray fluorescence microscopy reveals unique elemental signatures within sub-populations of hippocampal pyramidal neurons.

Graphical abstract: Elemental characterisation of the pyramidal neuron layer within the rat and mouse hippocampus
From the themed collection: Metallomics Emerging Investigators
Paper

Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1

Detailed quantitative in situ imaging of embryonic mice reveals overt Cu redistribution associated with SOD1-overexpression.

Graphical abstract: Anatomical redistribution of endogenous copper in embryonic mice overexpressing SOD1
From the themed collection: Metallomics Emerging Investigators
Paper

Organelle-specific analysis of labile Fe(II) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes

Fluorescence imaging analysis of labile Fe(II) during ferroptosis.

Graphical abstract: Organelle-specific analysis of labile Fe(ii) during ferroptosis by using a cocktail of various colour organelle-targeted fluorescent probes
From the themed collection: Metallomics Emerging Investigators
Open Access Paper

Time-dependent shotgun proteomics revealed distinct effects of an organoruthenium prodrug and its activation product on colon carcinoma cells

The target spectrum and cellular effects of a metallo-prodrug can be separated from its activated species by time-dependent shotgun proteomics.

Graphical abstract: Time-dependent shotgun proteomics revealed distinct effects of an organoruthenium prodrug and its activation product on colon carcinoma cells
From the themed collection: Metallomics Emerging Investigators
16 items

About this collection

This collection of invited papers highlights the excellent work being carried out by leading scientists at an early stage of their career, typically within approximately 10 years of completing their PhD. The collection is Guest Edited by Metallomics Editorial Board member Katherine Franz (Duke University, USA).

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