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Themed collection 2014 Emerging Investigators

14 items
Profile

Contributors to Emerging Investigators 2014

Guest Editors Ulrike Eggert and Michael Washburn introduce this year's Emerging Investigators issue and present the profiles of the contributing authors.

Graphical abstract: Contributors to Emerging Investigators 2014
From the themed collection: 2014 Emerging Investigators
Review Article

Discovery of protein–RNA networks

We review the latest advances and future challenges in experimental and computational investigation of protein–RNA networks.

Graphical abstract: Discovery of protein–RNA networks
From the themed collection: 2014 Emerging Investigators
Review Article

Engineering reduced evolutionary potential for synthetic biology

Biological devices can be redesigned to slow evolutionary degradation of their functions by altering how they are encoded in DNA sequences and by engineering host organisms with improved genetic stability.

Graphical abstract: Engineering reduced evolutionary potential for synthetic biology
From the themed collection: 2014 Emerging Investigators
Review Article

From cradle to grave: high-throughput studies of aging in model organisms

This review summarizes the development of high-throughput replicative lifespan and longevity aging assays in unicellular and nematode model organisms.

Graphical abstract: From cradle to grave: high-throughput studies of aging in model organisms
From the themed collection: 2014 Emerging Investigators
Review Article

Crosstalk between kinases and Nedd4 family ubiquitin ligases

Understanding the interplay between kinase and E3 ligase signaling pathways will allow better understanding of therapeutically relevant pathways and the design of small molecule therapeutics targeting these pathways.

Graphical abstract: Crosstalk between kinases and Nedd4 family ubiquitin ligases
From the themed collection: 2014 Emerging Investigators
Communication

Improved cyclopropene reporters for probing protein glycosylation

Cyclopropenes have emerged as a new class of bioorthogonal chemical reporters.

Graphical abstract: Improved cyclopropene reporters for probing protein glycosylation
From the themed collection: 2014 Emerging Investigators
Communication

Patterning of cells through patterning of biology

For the first time, patterns of cells have been constructed by spatially manipulating native gene expression. This control of expression was effected using light activated RNA interference (LARI), a technique in which knockdown of gene expression is modulated through siRNA modified with light cleavable groups.

Graphical abstract: Patterning of cells through patterning of biology
From the themed collection: 2014 Emerging Investigators
Paper

One third of dynamic protein expression profiles can be predicted by a simple rate equation

A simple rate equation predicts time-resolved expression for 1/3 of the tested genes and suggest two mutually exclusive modes of regulation.

Graphical abstract: One third of dynamic protein expression profiles can be predicted by a simple rate equation
From the themed collection: 2014 Emerging Investigators
Paper

Peroxisomes are juxtaposed to strategic sites on mitochondria

Peroxisomes are situated in the cell adjacent to specific subdomains of mitochondria such as the ER/Mitochondria contact site or sites enriched for the pyruvate dehydrogenase complex.

Graphical abstract: Peroxisomes are juxtaposed to strategic sites on mitochondria
From the themed collection: 2014 Emerging Investigators
Paper

The interactome of the atypical phosphatase Rtr1 in Saccharomyces cerevisiae

The interactome of the CTD phosphatase Rtr1 is regulated by the CTDK-I subunit Ctk1.

Graphical abstract: The interactome of the atypical phosphatase Rtr1 in Saccharomyces cerevisiae
From the themed collection: 2014 Emerging Investigators
Paper

Quantitative phosphoproteomic profiling of PINK1-deficient cells identifies phosphorylation changes in nuclear proteins

A quantitative phosphoproteomic method coupled with siRNA mediated silencing of a kinase associated with Parkinson's disease was applied to measure phosphorylation changes. The results indicate alterations in protein phosphorylation downstream of this kinase, potentially expanding our understanding of its function.

Graphical abstract: Quantitative phosphoproteomic profiling of PINK1-deficient cells identifies phosphorylation changes in nuclear proteins
From the themed collection: 2014 Emerging Investigators
Paper

A comprehensive analysis of the Streptococcus pyogenes and human plasma protein interaction network

A schematic figure for the analysis of bacterial interaction protein, 2 different MS methods are used.

Graphical abstract: A comprehensive analysis of the Streptococcus pyogenes and human plasma protein interaction network
From the themed collection: 2014 Emerging Investigators
Paper

Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange

Production of indigoidine can be enhanced by swapping a synthetic T domain into the NRPS IndC.

Graphical abstract: Creating functional engineered variants of the single-module non-ribosomal peptide synthetase IndC by T domain exchange
From the themed collection: 2014 Emerging Investigators
Open Access Method

A red light-controlled synthetic gene expression switch for plant systems

The gene switch can be induced to high expression levels in red light and is inactive in far-red-supplemented white light.

Graphical abstract: A red light-controlled synthetic gene expression switch for plant systems
From the themed collection: 2014 Emerging Investigators
14 items

About this collection

A Molecular BioSystems themed issue guest edited by Ulrike Eggert and Michael Washburn showcasing some of the top research from emerging investigators in chemical biology, systems biology and the -omics sciences, the core areas of Molecular BioSystems .

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