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Themed collection Lab on a Chip Emerging Investigators

21 items
Paper

A miniaturized push–pull-perfusion probe for few-second sampling of neurotransmitters in the mouse brain

Measuring neurotransmitters in the brain of living animals is a challenging task, especially when detailed information at high temporal resolution is required.

Graphical abstract: A miniaturized push–pull-perfusion probe for few-second sampling of neurotransmitters in the mouse brain
From the themed collection: Lab on a Chip Emerging Investigators
Paper

On-chip phenotypic investigation of combinatory antibiotic effects by generating orthogonal concentration gradients

We propose a microfluidic cell-based drug screening platform to investigate combinatory antibiotic effects by automatically generating concentration combinations.

Graphical abstract: On-chip phenotypic investigation of combinatory antibiotic effects by generating orthogonal concentration gradients
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism

Microfluidic diffusional sizing is combined with synchrotron radiation circular dichroism to resolve the secondary structure of protein mixtures.

Graphical abstract: Resolving protein mixtures using microfluidic diffusional sizing combined with synchrotron radiation circular dichroism
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Functional TCR T cell screening using single-cell droplet microfluidics

Droplet-based single cell platform allows functional screening and sorting of desirable TCR T cells to accelerate development of adoptive T cell therapies.

Graphical abstract: Functional TCR T cell screening using single-cell droplet microfluidics
From the themed collection: Lab on a Chip Emerging Investigators
Paper

An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation

A biomimetic ‘adipose-tissue-on-chip’ integrated with nanoplasmonic biosensors for in situ multiplexed cytokine secretion analysis of obese adipose tissue.

Graphical abstract: An integrated adipose-tissue-on-chip nanoplasmonic biosensing platform for investigating obesity-associated inflammation
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Microfluidic diamagnetic water-in-water droplets: a biocompatible cell encapsulation and manipulation platform

We report a new technique that combines all aqueous droplet microfluidics with diamagnetic manipulation to isolate single-cell encapsulating water-in-water droplets.

Graphical abstract: Microfluidic diamagnetic water-in-water droplets: a biocompatible cell encapsulation and manipulation platform
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Measurement and mitigation of free convection in microfluidic gradient generators

Microfluidic gradient generators are used to study the movement of living cells, lipid vesicles, and colloidal particles in response to spatial variations in their local chemical environment.

Graphical abstract: Measurement and mitigation of free convection in microfluidic gradient generators
From the themed collection: Lab on a Chip Recent HOT Articles
Paper

A liver-immune coculture array for predicting systemic drug-induced skin sensitization

Recapitulation of liver-immune interactions in a microfluidic compartmentalized coculture array is sufficient to accurately predict systemic drug-induced skin sensitization.

Graphical abstract: A liver-immune coculture array for predicting systemic drug-induced skin sensitization
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Graphene-based biosensor for on-chip detection of bio-orthogonally labeled proteins to identify the circulating biomarkers of aging during heterochronic parabiosis

Click-A+Chip identifies azido modified proteins with a novel graphene linker that performs copper-free-click chemistry on the chip's surface.

Graphical abstract: Graphene-based biosensor for on-chip detection of bio-orthogonally labeled proteins to identify the circulating biomarkers of aging during heterochronic parabiosis
From the themed collection: Lab on a Chip Emerging Investigators
Paper

A microfluidic platform for lifelong high-resolution and high throughput imaging of subtle aging phenotypes in C. elegans

Aging produces a number of changes in the neuronal structure and function throughout a variety of organisms.

Graphical abstract: A microfluidic platform for lifelong high-resolution and high throughput imaging of subtle aging phenotypes in C. elegans
From the themed collection: Lab on a Chip Emerging Investigators
Paper

User-defined local stimulation of live tissue through a movable microfluidic port

A two-component, two-phase microfluidic device provides a movable port for user-selectable local stimulation of living tissue slices.

Graphical abstract: User-defined local stimulation of live tissue through a movable microfluidic port
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions

A novel lung airway-on-a-chip system that uses a suspended hydrogel to enable epithelial–matrix–smooth muscle cell interactions.

Graphical abstract: Microfluidic lung airway-on-a-chip with arrayable suspended gels for studying epithelial and smooth muscle cell interactions
From the themed collection: Organ-, body- and disease-on-a-chip systems
Paper

Flow dynamics control endothelial permeability in a microfluidic vessel bifurcation model

Endothelial barrier function is known to be regulated by a number of molecular mechanisms; however, the role of biomechanical signals associated with blood flow is comparatively less explored.

Graphical abstract: Flow dynamics control endothelial permeability in a microfluidic vessel bifurcation model
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Buffer-free integrative nanofluidic device for real-time continuous flow bioassays by ion concentration polarization

A novel portable device combining an aptamer probe and a nanofluidic component was developed, enabling the buffer-free continuous monitoring of small molecules in biological fluids.

Graphical abstract: Buffer-free integrative nanofluidic device for real-time continuous flow bioassays by ion concentration polarization
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Upgrading well plates using open microfluidic patterning

We developed an open microfluidic hydrogel-patterning technology that creates networks of cell culture chambers in well plates for multiculture experiments.

Graphical abstract: Upgrading well plates using open microfluidic patterning
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Automated microfluidic platform for systematic studies of colloidal perovskite nanocrystals: towards continuous nano-manufacturing

An automated microfluidic platform enables systematic high-throughput studies of mixing enhancement on the emission band-gap of in-flow synthesized perovskite quantum dots, resulting in kinetically tunable nanocrystals.

Graphical abstract: Automated microfluidic platform for systematic studies of colloidal perovskite nanocrystals: towards continuous nano-manufacturing
From the themed collection: Lab on a Chip Emerging Investigators
Paper

A microfluidic device for partial immobilization, chemical exposure and behavioural screening of zebrafish larvae

Movement response of zebrafish to chemicals is of interest in screening studies. We introduce a microfluidic device for partial immobilization, head L-arginine exposure and movement screening of zebrafish larvae under controlled conditions.

Graphical abstract: A microfluidic device for partial immobilization, chemical exposure and behavioural screening of zebrafish larvae
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Probing blood cell mechanics of hematologic processes at the single micron level

Single-micron PDMS devices provide insight into the biophysical effects that vascular matrices have on platelets, RBCs, and neutrophils.

Graphical abstract: Probing blood cell mechanics of hematologic processes at the single micron level
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics

Light-based 3D printing of alginate hydrogels using ionic crosslinking enables reversible patterning with controlled degradation.

Graphical abstract: Stereolithographic printing of ionically-crosslinked alginate hydrogels for degradable biomaterials and microfluidics
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Image-based feedback and analysis system for digital microfluidics

A new feedback and biological analysis system for digital microfluidics that uses an imaging based setup.

Graphical abstract: Image-based feedback and analysis system for digital microfluidics
From the themed collection: Lab on a Chip Emerging Investigators
Paper

Label-free ferrohydrodynamic cell separation of circulating tumor cells

A size-based ferrohydrodynamic cell separation (FCS) device capable of enriching intact circulating tumor cells with high throughput and high recovery rate.

Graphical abstract: Label-free ferrohydrodynamic cell separation of circulating tumor cells
From the themed collection: Personalised Medicine: Liquid Biopsy
21 items

About this collection

Lab on a Chip is please to present this growing web collection showcasing some of the best research in the field of miniaturisation being conducted by early career scientists. This series is edited by Dino Di Carlo (UCLA, USA), Yoon-Kyoung Cho (UNIST, South Korea) and Piotr Garstecki (IPC PAC, Poland), and aims to highlight up-and-coming researchers in the early stages of the independent careers.

This collection is updated when new Emerging Investigator series papers are published, so keep checking the page for new articles!

You can read our feature interviews with the corresponding authors included in the series on our blog. More details about the series and how to apply are available at rsc.li/loc-emerging

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