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Themed collection Analytical Atomic Spectrometry in Biomedical Sciences

29 items
Tutorial Review

X-ray absorption spectroscopy of biological samples. A tutorial

This tutorial presents the principle of X-ray absorption spectroscopy and reviews its application to the characterization of biological samples.

Graphical abstract: X-ray absorption spectroscopy of biological samples. A tutorial
Critical Review

Application of plasma spectrometry for the analysis of engineered nanoparticles in suspensions and products

Scanning electron micrograph of gold nanoparticles prepared with a low concentration of silver nitrate.

Graphical abstract: Application of plasma spectrometry for the analysis of engineered nanoparticles in suspensions and products
Critical Review

Direct speciation analysis of inorganic elements in single cells using X-ray absorption spectroscopy

This review looks at the advantages and limitations of using micro X-ray absorption spectroscopy for studying speciation of inorganic elements in single cells.

Graphical abstract: Direct speciation analysis of inorganic elements in single cells using X-ray absorption spectroscopy
From the themed collection: Speciation
Communication

Immunoaffinity assisted LC-ICP-MS—a versatile tool in biomedical research

A novel concept of combining immunochemistry with elemental speciation analysis has potential use for targeted protein and peptide quantification in complex biological matrices.

Graphical abstract: Immunoaffinity assisted LC-ICP-MS—a versatile tool in biomedical research
Communication

Sample introduction of single selenized yeast cells (Saccharomyces cerevisiae) by micro droplet generation into an ICP-sector field mass spectrometer for label-free detection of trace elements

Metals and semi-metals are detected label free in single selenized yeast cells for the first time using an ICP-SFMS.

Graphical abstract: Sample introduction of single selenized yeast cells (Saccharomyces cerevisiae) by micro droplet generation into an ICP-sector field mass spectrometer for label-free detection of trace elements
Communication

A dual-labelling strategy for integrated ICPMS and LIF for the determination of peptides

A novel dual-labelling strategy with MMA-DOTA-Eu and FITC was developed for the determination of peptides using HPLC-ICPMS and CE-LIF.

Graphical abstract: A dual-labelling strategy for integrated ICPMS and LIF for the determination of peptides
Paper

Detection of selenoproteins in human cell extracts by laser ablation-ICP MS after separation by polyacrylamide gel electrophoresis and blotting

Laser ablation-ICP MS was optimized for the sensitive detection of selenoproteins in polyacrylamide gel and PVDF membrane after blotting.

Graphical abstract: Detection of selenoproteins in human cell extracts by laser ablation-ICP MS after separation by polyacrylamide gel electrophoresis and blotting
Paper

Inductively coupled plasma mass spectrometry for determination of total urinary protein with CdTequantum dots label

A novel methodology for sensitive quantification of total urinary protein by using CdTe quantum dots label and ICP-MS was proposed.

Graphical abstract: Inductively coupled plasma mass spectrometry for determination of total urinary protein with CdTe quantum dots label
Paper

Solid sampling high-resolution continuum source graphite furnace atomic absorption spectrometry to monitor the biodistribution of gold nanoparticles in mice tissue after intravenous administration

This paper explores the potential of high-resolution continuum source GFAAS for monitoring the biodistribution of Au nanoparticles in animal tissues.

Graphical abstract: Solid sampling high-resolution continuum source graphite furnace atomic absorption spectrometry to monitor the biodistribution of gold nanoparticles in mice tissue after intravenous administration
Paper

Bioimaging of metals in thin mouse brain section by laser ablation inductively coupled plasma mass spectrometry: novel online quantification strategy using aqueous standards

A novel solution-based calibration method for quantitative elements imaging in brain tissue sections by LA-ICP-MS is described.

Graphical abstract: Bioimaging of metals in thin mouse brain section by laser ablation inductively coupled plasma mass spectrometry: novel online quantification strategy using aqueous standards
Paper

Determination of five arsenic species in whole blood by liquid chromatography coupled with inductively coupled plasma mass spectrometry

A Vivaspin ultrafiltration device is used to prepare whole blood for LC separation of 5 arsenic species using a TBAH ion pair reagent with ICP-MS detection at m/z 75.

Graphical abstract: Determination of five arsenic species in whole blood by liquid chromatography coupled with inductively coupled plasma mass spectrometry
Paper

Metal-containing polystyrene beads as standards for mass cytometry

A bivariate plot of mass cytometry results for cells mixed with polymer beads.

Graphical abstract: Metal-containing polystyrene beads as standards for mass cytometry
From the themed collection: 2010 Young Analytical Scientists
Paper

Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis

The element distributions in a mouse brain are quantitatively determined with SRXRF using Compton scattering normalization.

Graphical abstract: Quantitative imaging of element spatial distribution in the brain section of a mouse model of Alzheimer's disease using synchrotron radiation X-ray fluorescence analysis
From the themed collection: 2010 Young Analytical Scientists
Paper

Bio-functional, lanthanide-labeled polymer particles by seeded emulsion polymerization and their characterization by novel ICP-MS detection

A novel method for the analysis of metal-labeled polymer particles by ICP-MS is presented. These particles have relevant surface chemistry for bioconjugation and subsequent use in assays for the detection of biological moieties.

Graphical abstract: Bio-functional, lanthanide-labeled polymer particles by seeded emulsion polymerization and their characterization by novel ICP-MS detection
From the themed collection: 2010 Young Analytical Scientists
Paper

Isotopic analysis of Cu in serum samples for diagnosis of Wilson's disease: a pilot study

Cu in the serum of patients with Wilson's disease shows a lighter isotopic composition than that in the serum of supposedly healthy individuals, thus making Cu isotopic analysis via multi-collector ICP-MS a potential tool for diagnosis of this disease.

Graphical abstract: Isotopic analysis of Cu in serum samples for diagnosis of Wilson's disease: a pilot study
Paper

Speciation of selenium in cells by HPLC-ICP-MS after (on-chip) magnetic solid phase extraction

Novel methods of (on-chip) magnetic solid phase extraction combined with high performance liquid chromatography-inductively coupled plasma mass spectrometry were proposed for selenium speciation in selenium-enriched yeast cells.

Graphical abstract: Speciation of selenium in cells by HPLC-ICP-MS after (on-chip) magnetic solid phase extraction
From the themed collection: 2013's Top 25 most read JAAS articles
Paper

MeCAT labeling for absolute quantification of intact proteins using label-specific isotope dilution ICP-MS

Absolute quantification of intact proteins labeled with MeCAT-IA using label-specific isotope dilution ICP-MS. Comparison of laser ablation and direct infusion of the mineralized spot for standard and blood serum proteins.

Graphical abstract: MeCAT labeling for absolute quantification of intact proteins using label-specific isotope dilution ICP-MS
Paper

LA-ICP-MS and nHPLC-ESI-LTQ-FT-MS/MS for the analysis of cisplatin–protein complexes separated by two dimensional gel electrophoresis in biological samples

A methodology for the analysis of Pt–protein complexes in cisplatin-treated biological samples is presented.

Graphical abstract: LA-ICP-MS and nHPLC-ESI-LTQ-FT-MS/MS for the analysis of cisplatin–protein complexes separated by two dimensional gel electrophoresis in biological samples
Paper

Comparison of different chelates for lanthanide labeling of antibodies and application in a Western blot immunoassay combined with detection by laser ablation (LA-)ICP-MS

In this paper an antibody labeling strategy via MeCAT was developed. The reagent is compared to two other established labeling methods (MAXPAR™, SCN-DOTA) using complex samples in a Western blot immunoassay measured by LA-ICP-MS.

Graphical abstract: Comparison of different chelates for lanthanide labeling of antibodies and application in a Western blot immunoassay combined with detection by laser ablation (LA-)ICP-MS
Paper

LA-ICP-MS with microarray chip sampling to determine holoceruloplasmin in serum

Determination of holoceruloplasmin in serum using laser ablation ICP-MS with microarray chip sampling.

Graphical abstract: LA-ICP-MS with microarray chip sampling to determine holoceruloplasmin in serum
From the themed collection: Nanoanalysis
Paper

A pilot study on the use of laser ablation-ICP-mass spectrometry for assessing/mapping the distribution of a drug and its metabolites across the body compartments of rats

The distribution of a Br-containing anti-TB drug over the organs of rats was visualized and semi-quantitatively assessed via spatially resolved analysis of thin sections using LA-ICP-MS.

Graphical abstract: A pilot study on the use of laser ablation-ICP-mass spectrometry for assessing/mapping the distribution of a drug and its metabolites across the body compartments of rats
Paper

Iodine as an elemental marker for imaging of single cells and tissue sections by laser ablation inductively coupled plasma mass spectrometry

A new LA-ICP-MS based method was developed for single cell imaging and internal standardization for tissue thin sections in LA-ICP-MS.

Graphical abstract: Iodine as an elemental marker for imaging of single cells and tissue sections by laser ablation inductively coupled plasma mass spectrometry
Paper

Mass spectrometric imaging of elements in biological tissues by new BrainMet technique—laser microdissectioninductively coupled plasma mass spectrometry (LMD-ICP-MS)

A novel bioimaging technique, LMD-ICP-MS, was developed to study elemental distribution in tissues with spatial resolution down to 4 μm.

Graphical abstract: Mass spectrometric imaging of elements in biological tissues by new BrainMet technique—laser microdissection inductively coupled plasma mass spectrometry (LMD-ICP-MS)
Paper

Magnetic quantitative immunoanalysis of carcinoembryonic antigen by ICP-MS with mercury labels

A novel nonisotopic immunoassay based on mercury labeled magnetic solid phase extraction-MCN-ICP-MS detection was proposed for the quantification of CEA.

Graphical abstract: Magnetic quantitative immunoanalysis of carcinoembryonic antigen by ICP-MS with mercury labels
Paper

Ultrasensitive, selective and simultaneous detection of cytochrome c and insulin based on immunoassay and aptamer-based bioassay in combination with Au/Ag nanoparticle tagging and ICP-MS detection

An ultrasensitive and specific method for simultaneous determination of cytochrome c (cyt-c) and insulin was developed by combining aptamer-based bioassay and immunoassay, multielement-tagging and ICP-MS.

Graphical abstract: Ultrasensitive, selective and simultaneous detection of cytochrome c and insulin based on immunoassay and aptamer-based bioassay in combination with Au/Ag nanoparticle tagging and ICP-MS detection
Paper

Quantitative determination of intact free cisplatin in cell models by LC-ICP-MS

Two complementary LC-ICP-MS methods were successfully applied for quantification of intact, free cisplatin in cytosol of cancer cells. Cellular uptake studies of cisplatin were performed at preclincally relevant experimental conditions (drug exposure in the low µM range).

Graphical abstract: Quantitative determination of intact free cisplatin in cell models by LC-ICP-MS
From the themed collection: Speciation
Paper

Reactivity of anticancer metallodrugs with serum proteins: new insights from size exclusion chromatography-ICP-MS and ESI-MS

The metal binding of anticancer metallodrugs, cisplatin and RAPTA-T, to serum proteins albumin and transferrin was investigated by ICP-MS and ESI-MS.

Graphical abstract: Reactivity of anticancer metallodrugs with serum proteins: new insights from size exclusion chromatography-ICP-MS and ESI-MS
From the themed collection: 2010 Young Analytical Scientists
Technical Note

Accelerator mass spectrometry in the attomolar concentration range for 14C-labeled biologically active compounds in complex matrixes

Accelerator mass spectrometry in combination with column switching and Restricted Access Media column facilitates concentration measurements of drugs in blood down to 450 attomolar.

Graphical abstract: Accelerator mass spectrometry in the attomolar concentration range for 14C-labeled biologically active compounds in complex matrixes
Technical Note

Isotopic analysis of the metabolically relevant transition metals Cu, Fe and Zn in human blood from vegetarians and omnivores using multi-collector ICP-mass spectrometry

Isotopic analysis of Fe, Cu and Zn from healthy donors using multi-collector ICP-MS reveals the influence of gender on the isotopic composition of Fe and that of diet (vegetarian vs. omnivorous) on the isotopic composition of Zn.

Graphical abstract: Isotopic analysis of the metabolically relevant transition metals Cu, Fe and Zn in human blood from vegetarians and omnivores using multi-collector ICP-mass spectrometry
29 items

About this collection

Highlighting the achievements in analytical atomic spectrometry and applications of spectroscopy-based bio-analytical technologies in clinics and biology.

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