Themed collection Integrative Biology Most Downloaded Articles
New advances in probing cell–extracellular matrix interactions
This review highlights the application of recent innovations in microtechnologies, biomaterials, and imaging tools for probing cell–ECM interactions.
T cell immunoengineering with advanced biomaterials
Biomaterial interfaces can present soluble and physical cues on the nano- and micro-scale to control T cell behaviour.
Aptamer-functionalized nano/micro-materials for clinical diagnosis: isolation, release and bioanalysis of circulating tumor cells
Aptamer-functionalized nano/micro-materials have enabled efficient cell-specific recognition, isolation, release and complete subsequent characterization for future clinical therapy guidance.
Next generation of network medicine: interdisciplinary signaling approaches
We synthesize topics often presented in dedicated reviews to argue that network medicine should be truly interdisciplinary to revolutionize medicine.
CRISPR-Cas9 technology: applications in genome engineering, development of sequence-specific antimicrobials, and future prospects
The development of CRISPR-Cas9 technology has revolutionized our ability to edit DNA and to modulate expression levels of genes of interest, thus providing powerful tools to accelerate the precise engineering of a wide range of organisms.
Liquid biopsy on chip: a paradigm shift towards the understanding of cancer metastasis
This review provides a framework for development of on-chip liquid biopsy platforms for capture, detection, and analysis of circulating tumor cells.
New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling
A combined approach involving microfluidic pulsatile stimulation and mathematical modeling has led to deciphering of hidden/unknown temporal motifs in several mammalian signaling pathways and has provided mechanistic insights, including how these motifs process temporal signals and govern fate regulation.
Integrating perfusable vascular networks with a three-dimensional tissue in a microfluidic device
Creating vascular networks in tissues is crucial for tissue engineering.
Correlation of focal adhesion assembly and disassembly with cell migration on nanotopography
We provide a dynamic perspective of how nanotopography regulate adhesions at the single molecular level.
PEG–peptide hydrogels reveal differential effects of matrix microenvironmental cues on melanoma drug sensitivity
The effects of systematic microenvironmental changes on melanoma drug responsiveness were assessed and found to depend on the stage of progression and culture conditions.
About this collection
This web collection features the top 10 most downloaded articles published in Integrative Biology in 2017. Congratulations to all of the authors whose articles have been featured!