Exploring DNA–protein interactions on the single DNA molecule level using nanofluidic tools
This review highlights the use of nanofluidic channels for studying DNA–protein interactions on the single DNA molecule level.
An engineering design approach to systems biology
An engineering approach to systems biology applies educational philosophy, engineering design, and predictive models to solve contemporary problems in biomedicine.
Fingerprinting microbiomes towards screening for microbial antibiotic resistance
There is an increasing need to investigate microbiomes in their entirety in a variety of contexts ranging from environmental to human health scenarios.
New advances in probing cell–extracellular matrix interactions
This review highlights the application of recent innovations in microtechnologies, biomaterials, and imaging tools for probing cell–ECM interactions.
T cell immunoengineering with advanced biomaterials
Biomaterial interfaces can present soluble and physical cues on the nano- and micro-scale to control T cell behaviour.
Super-resolution imaging of alpha-synuclein polymorphisms and their potential role in neurodegeneration
The conversion of soluble, functional proteins into amyloid fibrils has been linked to the development of neurodegenerative disorders, including Parkinson's and Alzheimer's disease.
Aptamer-functionalized nano/micro-materials for clinical diagnosis: isolation, release and bioanalysis of circulating tumor cells
Aptamer-functionalized nano/micro-materials have enabled efficient cell-specific recognition, isolation, release and complete subsequent characterization for future clinical therapy guidance.
Next generation of network medicine: interdisciplinary signaling approaches
We synthesize topics often presented in dedicated reviews to argue that network medicine should be truly interdisciplinary to revolutionize medicine.
CRISPR-Cas9 technology: applications in genome engineering, development of sequence-specific antimicrobials, and future prospects
The development of CRISPR-Cas9 technology has revolutionized our ability to edit DNA and to modulate expression levels of genes of interest, thus providing powerful tools to accelerate the precise engineering of a wide range of organisms.
Liquid biopsy on chip: a paradigm shift towards the understanding of cancer metastasis
This review provides a framework for development of on-chip liquid biopsy platforms for capture, detection, and analysis of circulating tumor cells.
New insights into mammalian signaling pathways using microfluidic pulsatile inputs and mathematical modeling
A combined approach involving microfluidic pulsatile stimulation and mathematical modeling has led to deciphering of hidden/unknown temporal motifs in several mammalian signaling pathways and has provided mechanistic insights, including how these motifs process temporal signals and govern fate regulation.
About this collection
In addition to high quality research papers, Integrative Biology features topical review articles. This web collection brings together recent reviews. Reviews will be added to this webpage as soon as possible after publication.