SCHEDULED MAINTENANCE
Systems biology of neurodegenerative diseases
Systems biology is a powerful tool for deciphering complex mechanisms driving neurodegenerative diseases.
Multiscale analysis of the murine intestine for modeling human diseases
When functioning properly, the intestine is one of the key interfaces between the human body and its environment.
Systems biology of the microvasculature
Integrated multi-scale physiological models are used to simulate the maintenance, pathological disruption, and therapeutic rebalancing of vascular networks.
A multi-scale approach to designing therapeutics for tuberculosis
Computational models constructed by integrating data from multiple model systems are used to investigate antibiotic, cytokine, and vaccine therapies.
Abstracting the principles of development using imaging and modeling
Developmental biology is entering a quantitative era that calls for a balanced investigation approach that integrates imaging, modeling and perturbation.
About this collection
A broadly relevant understanding of biology at the organismal level requires approaches that allow for the collection and interpretation of complex datasets derived from whole organisms. This can be achieved through the integrated experimental and computational approaches of systems biology. This issue of Integrative Biology guest edited by Doug Lauffenburger and Kevin Haigis will highlight recent efforts to apply computational modelling approaches to complex in vivo experimental systems and provide insights into how similar approaches may help us to understand organismal biology in a way that is unprecedented.