Themed collection Continuous processing and flow chemistry in the pharmaceutical industry
Recent advances in flow chemistry in the pharmaceutical industry
This themed issue showcases how continuous flow technology is increasingly being used in both the discovery and development of therapeutic agents.
The scale-up of continuous biphasic liquid/liquid reactions under super-heating conditions: methodology and reactor design
In this paper we explore and propose a methodology for the scale-up of continuous biphasic liquid/liquid reactions under super-heating conditions.
Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles
The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described.
Development of a concise, scalable synthesis of a CCR1 antagonist utilizing a continuous flow Curtius rearrangement
A convergent and robust synthesis of a developmental CCR1 antagonist is described using continuous flow technology.
A scalable and safe continuous flow procedure for in-line generation of diazomethane and its precursor MNU
A green approach towards the on-demand in-line generation of MNU and diazomethane in a continuous flow.
A laboratory-scale annular continuous flow reactor for UV photochemistry using excimer lamps for discrete wavelength excitation and its use in a wavelength study of a photodecarboxlyative cyclisation
A novel annular flow reactor for UV photochemistry.
Toolbox study for application of hydrogen peroxide as a versatile, safe and industrially-relevant green oxidant in continuous flow mode
Hydrogen peroxide is showcased in a range of oxidations, operating in continuous-flow equipment to deliver practical and risk-minimized procedures.
About this collection
This themed issue aims to showcase recent advances in the field of continuous processing and flow chemistry technology in drug discovery and development. This issue is guest-edited by Stefan Koenig (Genentech, a member if the Roche Group) and Helen Sneddon (GlaxoSmithKline and Green Chemistry Editorial Board member).