Issue 6, 2017

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

Abstract

The application of Reformatsky and Blaise reactions for the preparation of a diverse set of valuable intermediates and heterocycles in a one-pot protocol is described. To achieve this goal, a greener activation protocol for zinc in flow conditions has been developed to introduce this metal efficiently into α-bromoacetates. The organozinc compounds were added to a diverse set of ketones and nitriles to obtain a wide range of functional groups and heterocyclic systems.

Graphical abstract: Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

Supplementary files

Article information

Article type
Communication
Submitted
19 Sep 2016
Accepted
21 Oct 2016
First published
21 Oct 2016

Green Chem., 2017,19, 1420-1424

Reformatsky and Blaise reactions in flow as a tool for drug discovery. One pot diversity oriented synthesis of valuable intermediates and heterocycles

L. Huck, M. Berton, A. de la Hoz, A. Díaz-Ortiz and J. Alcázar, Green Chem., 2017, 19, 1420 DOI: 10.1039/C6GC02619B

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