Themed collection Radical Chemistry

15 items
Review Article

Recent advances in transition-metal-catalysed asymmetric coupling reactions with light intervention

The advances on transition-metal catalysed asymmetric couplings with light intervention in recent years was summarized in this review. In order to better meet the needs of modern chemistry, further research outlook was also proposed.

Graphical abstract: Recent advances in transition-metal-catalysed asymmetric coupling reactions with light intervention
From the themed collection: Radical Chemistry
Review Article

Catalytic three-component dicarbofunctionalization reactions involving radical capture by nickel

In this review, we summarize the recent advances in the area of catalytic dicarbofunctionalization of unsaturated π bonds by underpinning the catalytic domino transformations involving radical capture by nickel.

Graphical abstract: Catalytic three-component dicarbofunctionalization reactions involving radical capture by nickel
From the themed collection: Radical Chemistry
Review Article

Cysteinyl radicals in chemical synthesis and in nature

An overview of the unique reactivity of cysteinyl radical intermediates in both chemical synthesis and biological systems is provided, with a critical focus on mechanistic details.

Graphical abstract: Cysteinyl radicals in chemical synthesis and in nature
From the themed collection: Radical Chemistry
Open Access Review Article

Recent advances in visible light-activated radical coupling reactions triggered by (i) ruthenium, (ii) iridium and (iii) organic photoredox agents

Visible light-activated reactions continue to expand and diversify. The example shown here is a Birch reduction achieved by organophotoredox reagents.

Graphical abstract: Recent advances in visible light-activated radical coupling reactions triggered by (i) ruthenium, (ii) iridium and (iii) organic photoredox agents
From the themed collection: Radical Chemistry
Review Article

Advances in chemistry of N-heterocyclic carbene boryl radicals

This review focuses on synthesis and reactions of boryl radicals ligated by N-heterocyclic carbenes.

Graphical abstract: Advances in chemistry of N-heterocyclic carbene boryl radicals
From the themed collection: Radical Chemistry
Review Article

Molecular oxygen-mediated oxygenation reactions involving radicals

Molecular oxygen as a green, inexpensive oxidant and oxygen source has displayed lots of advantages compared to other oxidants. This review introduces the recent advances of radical processes in molecular oxygen-mediated oxygenation reactions.

Graphical abstract: Molecular oxygen-mediated oxygenation reactions involving radicals
From the themed collection: Radical Chemistry
Review Article

Electrocatalysis as an enabling technology for organic synthesis

Electrochemistry has recently gained increased attention as a versatile strategy for achieving challenging transformations at the forefront of synthetic organic chemistry.

Graphical abstract: Electrocatalysis as an enabling technology for organic synthesis
From the themed collection: Radical Chemistry
Review Article

Photochemical radical cyclization reactions with imines, hydrazones, oximes and related compounds

Photochemical reactions of imines, hydrazones, oximes and related compounds provides an efficient access to radical intermediates in the synthesis of heterocycles.

Graphical abstract: Photochemical radical cyclization reactions with imines, hydrazones, oximes and related compounds
From the themed collection: Radical Chemistry
Open Access Review Article

Dissociations of free radicals to generate protons, electrophiles or nucleophiles: role in DNA strand breaks

The concept behind the research described in this article was that of marrying the ‘soft’ methods of radical generation with the effectiveness and flexibility of nucleophile/electrophile synthetic procedures.

Graphical abstract: Dissociations of free radicals to generate protons, electrophiles or nucleophiles: role in DNA strand breaks
From the themed collection: Radical Chemistry
Review Article

Radical photoinitiation with LEDs and applications in the 3D printing of composites

Radical initiation upon LED light irradiation is discussed herein as well as its application in additive manufacturing.

Graphical abstract: Radical photoinitiation with LEDs and applications in the 3D printing of composites
From the themed collection: Radical Chemistry
Tutorial Review

Recent advances in electrochemical oxidative cross-coupling with hydrogen evolution involving radicals

This tutorial review provides an overview of the most recent developments in electrochemical oxidative cross-coupling with hydrogen evolution involving radicals.

Graphical abstract: Recent advances in electrochemical oxidative cross-coupling with hydrogen evolution involving radicals
From the themed collection: Radical Chemistry
Tutorial Review

Evolution towards green radical generation in total synthesis

This tutorial review outlines the evolution of methods for radical generation with applications in total synthesis, starting from classical methods towards greener methods that utilize recent advances in electrochemistry and photoredox catalysis.

Graphical abstract: Evolution towards green radical generation in total synthesis
From the themed collection: Radical Chemistry
Tutorial Review

Recent advances in the direct construction of enantioenriched stereocenters through addition of radicals to internal alkenes

This review highlights the recent significant progress in the realm of rapidly and conveniently building enantioenriched stereocenters via addition of radicals to internal alkenes.

Graphical abstract: Recent advances in the direct construction of enantioenriched stereocenters through addition of radicals to internal alkenes
From the themed collection: Radical Chemistry
Tutorial Review

Autoxidation vs. antioxidants – the fight for forever

Autoxidation limits the longevity of essentially all hydrocarbons and materials made therefrom – including us.

Graphical abstract: Autoxidation vs. antioxidants – the fight for forever
From the themed collection: Radical Chemistry
Tutorial Review

Radical trifluoromethylation

Radical trifluoromethylation has been emerging as a versatile tool for the synthesis of trifluoromethylated compounds that play increasingly important roles in pharmaceuticals, agrochemicals and materials science.

Graphical abstract: Radical trifluoromethylation
From the themed collection: Radical Chemistry
15 items

About this collection

The themed collection, Guest Edited by Xin-Yuan Liu (Southern University of Science and Technology) and John Walton (University of St. Andrews) is intended to inform readers on the latest advances in synthetic and mechanistic radical chemistry. A wide range of topics is envisaged including novel assembly and ring closure processes with carbon- and heteroatom-centred species. The collection will feature the hot area of radical catalytic processes, particularly single electron transfers and photoredox organocatalysed processes. The upsurge of interest in the role of metals in radical catalytic systems, especially with reference to stereocontrol, will be catered for. Innovative reagents will be introduced for the generation of radicals and their employment in functional group manipulations. Advances in the understanding of radical mediated oxidations and new antioxidants will also be incorporated.

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