Themed collection Molecular Medicine and Neurodegenerative Diseases

Guest editors Christopher J. Chang, Benjamin F. Cravatt, Douglas S. Johnson and Mi Hee Lim introduce the Molecular medicine and neurodegenerative diseases themed issue of Chemical Society Reviews.

Metals are functionally essential, but redistribute in neurodegenerative disease where they induce protein aggregates, catalyze radical formation, and lose bioavailability.

Increasing levels of glucose responsive O-GlcNAcylation of proteins in Alzheimer disease mouse models decreases the toxicity of tau and Aβ.

The review highlights the progress in the design and development of BACE1 (β-secretase) inhibitors for the treatment of Alzheimer's disease.

This review describes the development of inhibitors for endocannabinoid metabolism and their potential therapeutic benefit.

The use radioactive copper and technetium complexes as amyloid imaging agents, the use of luminescent metal complexes as non-conventional probes of amyloid formation and the potential of metal complexes to be inhibitors of amyloid toxicity are discussed.

Aggregation of small Aβ oligomers into common β-sheet rich annular structural motifs is responsible for Alzheimer's disease.

Overproduction of nitric oxide by neuronal nitric oxide synthase is implicated in neurodegenerative diseases and neuropathic pain; inhibition is therapeutically desirable.

The P7C3 compounds emerged from an in vivo screen and were found to protect neurons in models of neurodegenerative disease.

This review describes the possible involvement of cholesterol and metal ions in AD neuropathogenesis in both individual and interconnected manners.

Amyvid/PET imaging of a living brain detects β-amyloid plaque deposition, a risk factor for developing Alzheimer's disease.

The association of the amyloid-β (Aβ) peptide with cellular membranes is hypothesized to be the underlying phenomenon of neurotoxicity in Alzheimer's disease.