Themed collection Exploring multivalent carbohydrate-protein interactions with chemical ligations
Serum antibody screening using glycan arrays
Glycan microarrays provide a high-throughput platform to rapidly interrogate serum anti-glycan antibodies, identify new biomarkers for a variety of conditions, and analyze the immune system's response to vaccines and other treatments.
Glycomimetics for the inhibition and modulation of lectins
Carbohydrates are essential mediators of many processes in health and disease. The development of glycomimetics as inhibitors and modulators of their lectin receptors has been a success story with numerous molecules reaching clinical stages.
Carrier diversity and chemical ligations in the toolbox for designing tumor-associated carbohydrate antigens (TACAs) as synthetic vaccine candidates
This review highlights the recent development in the use of carriers of increasing simplicities and versatile chemical ligation processes leading to synthetic vaccine candidates against tumor-associated carbohydrate antigens (TACAs).
Glycopolymers against pathogen infection
Glycomacromolecules show significant potential as antimicrobials. We highlight recent studies on their performance in hindering host cell entry and biofilm formation, and their potential as drug delivery and diagnostic agents.
Exploring multivalent carbohydrate–protein interactions by NMR
Nuclear Magnetic Resonance (NMR) has been widely employed to assess diverse features of glycan–protein molecular recognition events.
Targeted delivery of oligonucleotides using multivalent protein–carbohydrate interactions
This review traces the development of targeted delivery of nucleic acids to liver cells using multivalent carbohydrate ligands.
Multivalent glycosystems for human lectins
This review summarises major contributions based on carbohydrate multivalent systems to study their interaction with human lectins.
Metabolic glycoengineering – exploring glycosylation with bioorthogonal chemistry
Metabolic glycoengineering in combination with bioorthogonal chemistry provides a means to study and exploit the biological functions of glycans.
Carbon-based glyco-nanoplatforms: towards the next generation of glycan-based multivalent probes
This review highlights the recent achievements in the field of carbon-based multivalent glyco-nanoplatforms with biological applications.
Multivalent glycocyclopeptides: conjugation methods and biological applications
In this review, we describe the conjugation methods used to construct multivalent glycocyclopeptides and their utilization for applications in glycoscience.
Glycan microarrays from construction to applications
This article summarizes the preparation of glycan probes, the construction of glycan microarrays and their applications for biological and biomedical research.
Peptide mimotopes to emulate carbohydrates
This review describes the design and preparation of peptide mimotopes, their structural and functional mimicry properties, and their advantages over that of glycan ligands in developing a therapeutic strategy to treat glycan-related diseases.
About this collection
Carbohydrate-protein interactions play central roles in biology. The utilization of ligation chemistry has revolutionized this field by providing powerful synthetic tools to understand and manipulate these interactions and develop a diversity of diagnostic and therapeutic applications. Following a previous themed issue on “Multivalent Scaffolds in Glycosciences” published in Chemical Society Reviews in 2013, we aim at giving an extended overview of the recent progress in this field, with a special focus on biological/disease applications. Different key aspects are covered, including antiadhesive glycoarchitectures, metabolic cell glycoengineering, synthetic vaccines/immunomodulators, biophysical tools and glycoarrays. This themed issue aims to represent a standard reference for the large scientific community involved in glycosciences.