Flexible imidazolium macrocycles: building blocks for anion-induced self-assembly
This feature article summarises recent contributions of the authors in the area of flexible imidazolium macrocycle and related anion-induced supramolecular self-assembly.
Bioactive clusters promoting cell penetration and nucleic acid complexation for drug and gene delivery applications: from designed to self-assembled and responsive systems
Recent developments in the (self-)assembly of cationic clusters promoting nucleic acids complexation and cell penetration open the door to applications in drug and gene delivery.
Thermally activated isomeric all-hydrocarbon molecular receptors for fullerene separation
A new thermally activated all-hydrocarbon rigid macrocycle receptors system, cyclo(1,3-(4,6-dimethyl)benzene) (CDMB-8) has been reported.
Reviving old protecting group chemistry for site-selective peptide–protein conjugation
Unprotected peptides equipped with property enhancing moieties and a Cys(Scm) residue can be site-selectively conjugated to proteins via crossed-disulfide formation.
Ultrasound-induced gelation of a giant macrocycle
Supramolecular gelation of a 68-membered macrocycle triggered by sonication.
Uracil grafted imine-based covalent organic framework for nucleobase recognition
An imine-based covalent organic framework (COF) decorated in its cavities with uracil groups has shown selective recognition towards adenine in water.
Polyvinyl alcohol–boronate gel for sodium hydroxide extraction
Gels formed from commercially available polyvinyl alcohol (PVA) and 1,4-benzene diboronic acid (BdBA) in DMSO absorb NaOH efficiently from a bulk aqueous solution decreasing its pH.
A giant M2L3 metallo-organic helicate based on phthalocyanines as a host for electroactive molecules
An unprecedented phthalocyanine-based, metallo-organic helicate (Fe2Pc3) has been assembled and proved as a host for large redox-active guests such as fullerenes and naphthalenediimides.
Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides
We demonstrate that both the R8 functionalization and its interplay with the ancillary ligand have and an important role in the G-quadruplex recognition process by Ru(dppz) metallopeptides.
Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences
G-quadruplexes (G4) represent attractive supramolecular scaffolds.
Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of L-allo-enduracididine with its isosteres
We have synthesised 8 simplified, potent teixobactin analogues by replacing L-allo-enduracididine with its isosteres.
In situ control of polymer helicity with a non-covalently bound photoresponsive molecular motor dopant
A molecular motor based photoswitchable dopant can induce and switch the helical chirality of a poly(phenylacetylene) dynamic helical polymer.
Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor
A gemini dicationic amphiphile forms gels with a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, and the release of the drug causes remarkable gel fibre coiling.
A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging
Light-up of nuclear G-quadruplex DNA in cells by an aggregating and red/NIR emitting dye.
A peptide functionalized nanomotor as an efficient cell penetrating tool
A novel peptide-nanomotor based hybrid system is presented for fast cell penetration and cargo delivery.
Superfluorinated and NIR-luminescent gold nanoclusters
A novel class of superfluorinated gold nanoclusters obtained from a branched thiol with 27 equivalent 19F atoms per molecule, which combine both NIR photoluminescence and 19F NMR properties, thus representing a promising multimodal nanoplatform for bioimaging applications.
Chiral supramolecular organization and cooperativity in DNA-templated assemblies of ZnII–chromophore complexes
Templated cooperative binding induced assembly of chromophores is achieved via interactions between Zn-complexes and the DNA phosphodiester backbone.
Well-defined, persistent, chiral phthalocyanine nanoclusters via G-quadruplex assembly
Monodisperse nanoclusters are produced via G-quadruplex assembly with potassium salts in which red-absorbing phthalocyanine dyes are arranged in a well-defined chiral organization.
Intramolecular transport of small-molecule cargo in a nanoscale device operated by light
A light-operated molecular nanodevice is able to transport an acetyl cargo intramolecularly over a distance of about 2 nm.
A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbituril–guest interactions
A fluorescent sensor displaying a significant increase in emission upon binding CB was developed and utilized in a surface-bound displacement assay for the rapid detection of CB encapsulation of therapeutically relevant drug classes.
Retaining individualities: the photodynamics of self-ordering porphyrin assemblies
Retained photochemical properties – a simple porphyrin–polyDMA conjugate with the ability to self assemble into large (∼1 μm) vesicles in water. The photodynamics are remarkably preserved despite the extensive aggregation.
In situ iodination and X-ray crystal structure of a foldamer helix bundle
We report here the efficient in situ iodination of tyrosine-type side-chains located within a foldamer helix bundle, permitting structure determination using single-wavelength anomalous diffraction (SAD) methods.
Efficient inhibition of human AP endonuclease 1 (APE1) via substrate masking by abasic site-binding macrocyclic ligands
Bis-naphthalene macrocycles bind to abasic sites in DNA, leading to efficient inhibition of their cleavage by human AP endonuclease 1 (APE1).
Promoting strand exchange in a DNA-templated transfer reaction
A comb-type polylysine–polydextran copolymer increases the turnover in DNA-templated acyl transfer reactions by promoting strand exchange.
fluorescence detection of the depurination activity of ribosome inactivating protein toxins
A simple label-free fluorescence hybridization assay to monitor the depurination activity of toxic ribosome inactivating proteins by using an abasic site sensing fluorescent ligand has been developed.
Helix stabilization through pyridinium–π interactions
Intramolecular cation–π interactions between a methyl pyridinium ion and a phenyl ring stabilize the folded structure of a phenyleneethynylene oligomer.
About this collection
This collection celebrates current achievements and future perspectives in Suprabiomolecular Chemistry, highlighting the fantastic work published by the speakers at this year’s SupraBio 2019 meeting.