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Themed collection Suprabiomolecular Chemistry

26 items
Feature Article

Flexible imidazolium macrocycles: building blocks for anion-induced self-assembly

This feature article summarises recent contributions of the authors in the area of flexible imidazolium macrocycle and related anion-induced supramolecular self-assembly.

Graphical abstract: Flexible imidazolium macrocycles: building blocks for anion-induced self-assembly
From the themed collection: Suprabiomolecular Chemistry
Feature Article

Bioactive clusters promoting cell penetration and nucleic acid complexation for drug and gene delivery applications: from designed to self-assembled and responsive systems

Recent developments in the (self-)assembly of cationic clusters promoting nucleic acids complexation and cell penetration open the door to applications in drug and gene delivery.

Graphical abstract: Bioactive clusters promoting cell penetration and nucleic acid complexation for drug and gene delivery applications: from designed to self-assembled and responsive systems
From the themed collection: Suprabiomolecular Chemistry
Communication

Thermally activated isomeric all-hydrocarbon molecular receptors for fullerene separation

A new thermally activated all-hydrocarbon rigid macrocycle receptors system, cyclo[8](1,3-(4,6-dimethyl)benzene) (CDMB-8) has been reported.

Graphical abstract: Thermally activated isomeric all-hydrocarbon molecular receptors for fullerene separation
From the themed collection: Suprabiomolecular Chemistry
Communication

Reviving old protecting group chemistry for site-selective peptide–protein conjugation

Unprotected peptides equipped with property enhancing moieties and a Cys(Scm) residue can be site-selectively conjugated to proteins via crossed-disulfide formation.

Graphical abstract: Reviving old protecting group chemistry for site-selective peptide–protein conjugation
From the themed collection: Suprabiomolecular Chemistry
Open Access Communication

Ultrasound-induced gelation of a giant macrocycle

Supramolecular gelation of a 68-membered macrocycle triggered by sonication.

Graphical abstract: Ultrasound-induced gelation of a giant macrocycle
From the themed collection: Suprabiomolecular Chemistry
Communication

Uracil grafted imine-based covalent organic framework for nucleobase recognition

An imine-based covalent organic framework (COF) decorated in its cavities with uracil groups has shown selective recognition towards adenine in water.

Graphical abstract: Uracil grafted imine-based covalent organic framework for nucleobase recognition
From the themed collection: Suprabiomolecular Chemistry
Communication

Polyvinyl alcohol–boronate gel for sodium hydroxide extraction

Gels formed from commercially available polyvinyl alcohol (PVA) and 1,4-benzene diboronic acid (BdBA) in DMSO absorb NaOH efficiently from a bulk aqueous solution decreasing its pH.

Graphical abstract: Polyvinyl alcohol–boronate gel for sodium hydroxide extraction
From the themed collection: Suprabiomolecular Chemistry
Communication

A giant M2L3 metallo-organic helicate based on phthalocyanines as a host for electroactive molecules

An unprecedented phthalocyanine-based, metallo-organic helicate (Fe2Pc3) has been assembled and proved as a host for large redox-active guests such as fullerenes and naphthalenediimides.

Graphical abstract: A giant M2L3 metallo-organic helicate based on phthalocyanines as a host for electroactive molecules
From the themed collection: Suprabiomolecular Chemistry
Communication

Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides

We demonstrate that both the R8 functionalization and its interplay with the ancillary ligand have and an important role in the G-quadruplex recognition process by Ru(dppz) metallopeptides.

Graphical abstract: Selective G-quadruplex binding by oligoarginine-Ru(dppz) metallopeptides
From the themed collection: Suprabiomolecular Chemistry
Communication

Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences

G-quadruplexes (G4) represent attractive supramolecular scaffolds.

Graphical abstract: Controlling G-quadruplex formation via lipid modification of oligonucleotide sequences
From the themed collection: Suprabiomolecular Chemistry
Communication

Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of L-allo-enduracididine with its isosteres

We have synthesised 8 simplified, potent teixobactin analogues by replacing L-allo-enduracididine with its isosteres.

Graphical abstract: Syntheses of potent teixobactin analogues against methicillin-resistant Staphylococcus aureus (MRSA) through the replacement of l-allo-enduracididine with its isosteres
From the themed collection: Suprabiomolecular Chemistry
Communication

In situ control of polymer helicity with a non-covalently bound photoresponsive molecular motor dopant

A molecular motor based photoswitchable dopant can induce and switch the helical chirality of a poly(phenylacetylene) dynamic helical polymer.

Graphical abstract: In situ control of polymer helicity with a non-covalently bound photoresponsive molecular motor dopant
From the themed collection: Suprabiomolecular Chemistry
Communication

Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor

A gemini dicationic amphiphile forms gels with a serine protease inhibitor, which could be used in a new approach to the treatment of Rosacea, and the release of the drug causes remarkable gel fibre coiling.

Graphical abstract: Microscale coiling in bis-imidazolium supramolecular hydrogel fibres induced by the release of a cationic serine protease inhibitor
From the themed collection: Suprabiomolecular Chemistry
Open Access Communication

A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging

Light-up of nuclear G-quadruplex DNA in cells by an aggregating and red/NIR emitting dye.

Graphical abstract: A red-NIR fluorescent dye detecting nuclear DNA G-quadruplexes: in vitro analysis and cell imaging
From the themed collection: Suprabiomolecular Chemistry
Communication

A peptide functionalized nanomotor as an efficient cell penetrating tool

A novel peptide-nanomotor based hybrid system is presented for fast cell penetration and cargo delivery.

Graphical abstract: A peptide functionalized nanomotor as an efficient cell penetrating tool
From the themed collection: Suprabiomolecular Chemistry
Communication

Superfluorinated and NIR-luminescent gold nanoclusters

A novel class of superfluorinated gold nanoclusters obtained from a branched thiol with 27 equivalent 19F atoms per molecule, which combine both NIR photoluminescence and 19F NMR properties, thus representing a promising multimodal nanoplatform for bioimaging applications.

Graphical abstract: Superfluorinated and NIR-luminescent gold nanoclusters
From the themed collection: Suprabiomolecular Chemistry
Communication

Chiral supramolecular organization and cooperativity in DNA-templated assemblies of ZnII–chromophore complexes

Templated cooperative binding induced assembly of chromophores is achieved via interactions between Zn-complexes and the DNA phosphodiester backbone.

Graphical abstract: Chiral supramolecular organization and cooperativity in DNA-templated assemblies of ZnII–chromophore complexes
From the themed collection: Suprabiomolecular Chemistry
Communication

Well-defined, persistent, chiral phthalocyanine nanoclusters via G-quadruplex assembly

Monodisperse nanoclusters are produced via G-quadruplex assembly with potassium salts in which red-absorbing phthalocyanine dyes are arranged in a well-defined chiral organization.

Graphical abstract: Well-defined, persistent, chiral phthalocyanine nanoclusters via G-quadruplex assembly
From the themed collection: Suprabiomolecular Chemistry
Communication

Intramolecular transport of small-molecule cargo in a nanoscale device operated by light

A light-operated molecular nanodevice is able to transport an acetyl cargo intramolecularly over a distance of about 2 nm.

Graphical abstract: Intramolecular transport of small-molecule cargo in a nanoscale device operated by light
From the themed collection: Suprabiomolecular Chemistry
Communication

A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions

A fluorescent sensor displaying a significant increase in emission upon binding CB[7] was developed and utilized in a surface-bound displacement assay for the rapid detection of CB[7] encapsulation of therapeutically relevant drug classes.

Graphical abstract: A naphthalimide derived fluorescent sensor for solid-phase screening of cucurbit[7]uril–guest interactions
From the themed collection: Suprabiomolecular Chemistry
Open Access Communication

Retaining individualities: the photodynamics of self-ordering porphyrin assemblies

Retained photochemical properties – a simple porphyrin–polyDMA conjugate with the ability to self assemble into large (∼1 μm) vesicles in water. The photodynamics are remarkably preserved despite the extensive aggregation.

Graphical abstract: Retaining individualities: the photodynamics of self-ordering porphyrin assemblies
From the themed collection: Suprabiomolecular Chemistry
Communication

In situ iodination and X-ray crystal structure of a foldamer helix bundle

We report here the efficient in situ iodination of tyrosine-type side-chains located within a foldamer helix bundle, permitting structure determination using single-wavelength anomalous diffraction (SAD) methods.

Graphical abstract: In situ iodination and X-ray crystal structure of a foldamer helix bundle
From the themed collection: Suprabiomolecular Chemistry
Communication

Efficient inhibition of human AP endonuclease 1 (APE1) via substrate masking by abasic site-binding macrocyclic ligands

Bis-naphthalene macrocycles bind to abasic sites in DNA, leading to efficient inhibition of their cleavage by human AP endonuclease 1 (APE1).

Graphical abstract: Efficient inhibition of human AP endonuclease 1 (APE1) via substrate masking by abasic site-binding macrocyclic ligands
From the themed collection: Suprabiomolecular Chemistry
Communication

Promoting strand exchange in a DNA-templated transfer reaction

A comb-type polylysine–polydextran copolymer increases the turnover in DNA-templated acyl transfer reactions by promoting strand exchange.

Graphical abstract: Promoting strand exchange in a DNA-templated transfer reaction
From the themed collection: Suprabiomolecular Chemistry
Communication

Label-free fluorescence detection of the depurination activity of ribosome inactivating protein toxins

A simple label-free fluorescence hybridization assay to monitor the depurination activity of toxic ribosome inactivating proteins by using an abasic site sensing fluorescent ligand has been developed.

Graphical abstract: Label-free fluorescence detection of the depurination activity of ribosome inactivating protein toxins
From the themed collection: Suprabiomolecular Chemistry
Communication

Helix stabilization through pyridinium–π interactions

Intramolecular cation–π interactions between a methyl pyridinium ion and a phenyl ring stabilize the folded structure of a phenyleneethynylene oligomer.

Graphical abstract: Helix stabilization through pyridinium–π interactions
From the themed collection: Suprabiomolecular Chemistry
26 items

About this collection

This collection celebrates current achievements and future perspectives in Suprabiomolecular Chemistry, highlighting the fantastic work published by the speakers at this year’s SupraBio 2019 meeting.

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