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Issue 6, 2016
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In situ iodination and X-ray crystal structure of a foldamer helix bundle

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Abstract

We report here the efficient in situ iodination of tyrosine-type side-chains located within a foldamer helix bundle, permitting structure determination using single-wavelength anomalous diffraction (SAD) methods. We suggest that this simple method may be of use to those engaged in structural foldamer research as a potential solution to the phase problem.

Graphical abstract: In situ iodination and X-ray crystal structure of a foldamer helix bundle

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Article information


Submitted
21 Sep 2015
Accepted
10 Nov 2015
First published
12 Nov 2015

Chem. Commun., 2016,52, 1202-1205
Article type
Communication

In situ iodination and X-ray crystal structure of a foldamer helix bundle

G. W. Collie, K. Pulka-Ziach and G. Guichard, Chem. Commun., 2016, 52, 1202
DOI: 10.1039/C5CC07916K

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